Drosophila Mechanosensory Transduction

TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

(2020) Lou Beaulieu-Laroche et al.   CELL

TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration

(2020) Amrutha Patkunarajah et al.   eLife

Parallel Mechanosensory Pathways Direct Oviposition Decision-Making in Drosophila

(2020) Liwei Zhang et al.   CURRENT BIOLOGY

Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor

(2020) Pingping Wang et al.   NEURON

Piezo-like Gene Regulates Locomotion in Drosophila Larvae

(2019) Yufei Hu et al.   Cell Reports

Ultrastructural organization of NompC in the mechanoreceptive organelle of Drosophila campaniform mechanoreceptors

(2019) Landi Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration

(2019) Yuanquan Song et al.   NEURON

A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel

(2019) David Argudo et al.   JOURNAL OF GENERAL PHYSIOLOGY

Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc

(2019) Liping He et al.   CURRENT BIOLOGY

A Neural Circuit Encoding the Experience of Copulation in Female Drosophila

(2019) Lisha Shao et al.   NEURON

Structure-guided examination of the mechanogating mechanism of PIEZO2

(2019) Francisco J. Taberner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila

(2019) Shun-Fan Wu et al.   eLife

Force-induced conformational changes in PIEZO1

(2019) Yi-Chih Lin et al.   NATURE

TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels

(2019) Yanyan Jia et al.   NEURON

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

(2018) Li He et al.   NATURE

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

Fast intensity adaptation enhances the encoding of sound in Drosophila

(2018) Jan Clemens et al.   Nature Communications

Voltage gating of mechanosensitive PIEZO channels

(2018) Mirko Moroni et al.   Nature Communications

Brv1 Is Required for Drosophila Larvae to Sense Gentle Touch

(2018) Mingfeng Zhang et al.   Cell Reports

Neural Coding of Leg Proprioception in Drosophila

(2018) Akira Mamiya et al.   NEURON

Function and Dysfunction of TMC Channels in Inner Ear Hair Cells

(2018) David P. Corey et al.   Cold Spring Harbor Perspectives in Medicine

Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation

(2017) Thomas Effertz et al.   JOURNAL OF NEUROSCIENCE

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A mechanosensory receptor required for food texture detection in Drosophila

(2017) Juan Antonio Sánchez-Alcañiz et al.   Nature Communications

Structure-based membrane dome mechanism for Piezo mechanosensitivity

(2017) Yusong R Guo et al.   eLife

Coupled Sensing of Hunger and Thirst Signals Balances Sugar and Water Consumption

(2016) Nicholas Jourjine et al.   CELL

A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles

(2016) J. Li et al.   JOURNAL OF NEUROSCIENCE

The Basis of Food Texture Sensation in Drosophila

(2016) Yali V. Zhang et al.   NEURON

Transmembrane channel-like (tmc) gene regulatesDrosophilalarval locomotion

(2016) Yanmeng Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

(2016) Awani Upadhyay et al.   Nature Communications

Mechanosensory neurons control sweet sensing in Drosophila

(2016) Yong Taek Jeong et al.   Nature Communications

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel

(2015) Wei Zhang et al.   CELL

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

TRP Channels in Insect Stretch Receptors as Insecticide Targets

(2015) Alexandre Nesterov et al.   NEURON

Coordination and fine motor control depend on Drosophila TRPγ

(2015) Bradley Akitake et al.   Nature Communications

Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing

(2015) Somdatta Karak et al.   Scientific Reports

Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons

(2015) Thomas J. Suslak et al.   PLoS One

Balboa Binds to Pickpocket In Vivo and Is Required for Mechanical Nociception in Drosophila Larvae

(2014) Stephanie E. Mauthner et al.   CURRENT BIOLOGY

Mechanosensory interactions drive collective behaviour in Drosophila

(2014) Pavan Ramdya et al.   NATURE

Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila

(2014) David A. Gorczyca et al.   Cell Reports

The Role of PPK26 in Drosophila Larval Mechanical Nociception

(2014) Yanmeng Guo et al.   Cell Reports

Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae

(2014) Wei Zhang et al.   eLife

A NOMPC-Dependent Membrane-Microtubule Connector Is a Candidate for the Gating Spring in Fly Mechanoreceptors

(2013) Xin Liang et al.   CURRENT BIOLOGY

NOMPC is likely a key component ofDrosophilamechanotransduction channels

(2013) Jiaxin Gong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distinct Roles of TRP Channels in Auditory Transduction and Amplification in Drosophila

(2013) Brendan P. Lehnert et al.   NEURON

Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae

(2013) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Filopodia, Ripped Pocket, NOMPC, and NMDARs Contribute to the Sense of Touch in Drosophila Larvae

(2012) Asako Tsubouchi et al.   CURRENT BIOLOGY

Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation

(2012) Zhiqiang Yan et al.   NATURE

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1

(2012) Thomas Effertz et al.   NATURE NEUROSCIENCE

Photomechanical Responses in Drosophila Photoreceptors

(2012) R. C. Hardie et al.   SCIENCE

NompC TRP Channel Is Essential for Drosophila Sound Receptor Function

(2011) Thomas Effertz et al.   CURRENT BIOLOGY

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

Pickpocket Is a DEG/ENaC Protein Required for Mechanical Nociception in Drosophila Larvae

(2010) Lixian Zhong et al.   CURRENT BIOLOGY

Transcuticular optical imaging of stimulus-evoked neural activities in the Drosophila peripheral nervous system

(2010) Azusa Kamikouchi et al.   Nature Protocols

C. elegans TRP Family Protein TRP-4 Is a Pore-Forming Subunit of a Native Mechanotransduction Channel

(2010) Lijun Kang et al.   NEURON

The Role of the TRP Channel NompC in Drosophila Larval and Adult Locomotion

(2010) Li E. Cheng et al.   NEURON

Response to Mechanical Stress Is Mediated by the TRPA Channel Painless in the Drosophila Heart

(2010) Sébastien Sénatore et al.   PLoS Genetics

Distinct sensory representations of wind and near-field sound in the Drosophila brain

(2009) Suzuko Yorozu et al.   NATURE

The neural basis of Drosophila gravity-sensing and hearing

(2009) Azusa Kamikouchi et al.   NATURE

TRPA channels distinguish gravity sensing from hearing in Johnston's organ

(2009) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transducer-Based Force Generation Explains Active Process in Drosophila Hearing

(2008) Björn Nadrowski et al.   CURRENT BIOLOGY

How Drosophila melanogaster Forms its Mechanoreceptors

(2008) D. Furman et al.   CURRENT GENOMICS

Drosophila Painless Is a Ca2+-Requiring Channel Activated by Noxious Heat

(2008) T. Sokabe et al.   JOURNAL OF NEUROSCIENCE