Voltage gating of mechanosensitive PIEZO channels

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Heterologous Expression of the Piezo1-ASIC1 Chimera Induces Mechanosensitive Currents with Properties Distinct from Piezo1

(2017) Qiancheng Zhao et al.   NEURON

Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization

(2017) Adrienne E. Dubin et al.   NEURON

Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix

(2017) Jason Wu et al.   Cell Reports

Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels

(2017) Amanda H. Lewis et al.   Cell Reports

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

(2017) M Rocio Servin-Vences et al.   eLife

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

(2016) Marcus Schewe et al.   CELL

Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures

(2016) A.A. Mahmud et al.   CLINICAL GENETICS

Piezo2 senses airway stretch and mediates lung inflation-induced apnoea

(2016) Keiko Nonomura et al.   NATURE

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

(2016) Christiane Wetzel et al.   NATURE NEUROSCIENCE

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels

(2016) Qiancheng Zhao et al.   NEURON

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

(2015) Viktor Lukacs et al.   Nature Communications

Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis

(2015) Elisavet Fotiou et al.   Nature Communications

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

(2015) Kevin Retailleau et al.   Cell Reports

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Piezo2 channel conductance and localization domains in Merkel cells of rat whisker hair follicles

(2014) Ryo Ikeda et al.   NEUROSCIENCE LETTERS

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+channels

(2014) Stephen G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

(2014) Kate Poole et al.   Nature Communications

Human PIEZO1: Removing Inactivation

(2013) Chilman Bae et al.   BIOPHYSICAL JOURNAL

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1

(2013) I. Andolfo et al.   BLOOD

Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report

(2013) Boris E. Shmukler et al.   BLOOD CELLS MOLECULES AND DISEASES

Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

(2013) C. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Gating the mechanical channel Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

(2012) Adrienne E. Dubin et al.   Cell Reports

In Glycine and GABAAChannels, Different Subunits Contribute Asymmetrically to Channel Conductance via Residues in the Extracellular Domain

(2011) Mirko Moroni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Peripheral sensitisation of nociceptors via G-proteindependent potentiation of mechanotransduction currents

(2009) Stefan G. Lechner et al.   JOURNAL OF PHYSIOLOGY-LONDON

The mechano-gated K2P channel TREK-1

(2008) Alexandra Dedman et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Sensing voltage across lipid membranes

(2008) Kenton J. Swartz   NATURE