Article
Multidisciplinary Sciences
Soo Min Oh, Kyunghwa Jeong, Jeong Taeg Seo, Seok Jun Moon
Summary: Through studying fruit flies, we have found that multimodal sensory integration plays a role in feeding behavior, particularly the contributions of olfactory and mechanical inputs to taste-evoked feeding behavior. Controlled delivery of three different sensory cues can produce a supra-additive reflex. Fruit flies serve as a versatile model system for studying multisensory integration related to feeding, which likely also exists in vertebrates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Bingxue Li, Songling Li, Honglan Zheng, Zhiqiang Yan
Summary: Research shows that in Drosophila larvae, the MET currents in Cho neurons are mediated by two TRPV channels, NAN and IAV, with the C-terminal residues 857 through 990 of IAV regulating the kinetics of MET currents. Additionally, the NompC channel contributes to the adaptation of auditory transduction currents.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Subash Dhakal, Qiuting Ren, Jiangqu Liu, Bradley Akitake, Izel Tekin, Craig Montell, Youngseok Lee
Summary: This study revealed the critical role of TRP gamma in coordinating food choice and metabolic state in starved fruit flies through its expression in neuroendocrine cells.
Article
Neurosciences
Alexa Joanna Roemmich, Thy Vu, Tamas Lukacsovich, Charlesice Hawkins, Soleil S. Schutte, Diane K. O'Dowd
Summary: Mutations in the voltage-gated sodium channel gene SCN1A are associated with human epilepsy disorders. This study found that Drosophila lines with R-C or R-H mutations showed reduced lifespan and seizures, while electrophysiological recordings revealed sustained neuronal depolarizations and altered firing frequency. The only significant change observed in sodium currents was a hyperpolarized deactivation threshold in R-C and R-H mutants.
Review
Physiology
Mengning Zheng, Niyati A. Borkar, Yang Yao, Xianwei Ye, Elizabeth R. Vogel, Christina M. Pabelick, Y. S. Prakash
Summary: Mechanosensitive channels play a crucial role in cell sensing and response, and the mechanical activation of ion channels and downstream signaling pathways is important for maintaining physiological homeostasis and the development of diseases. Understanding TRP and Piezo channels in the lung can provide new insights for pulmonary disease treatment.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neurosciences
Florencia Fernandez-Chiappe, Lia Frenkel, Carina Celeste Colque, Ana Ricciuti, Bryan Hahm, Karina Cerredo, Nara Ines Muraro, Maria Fernanda Ceriani
Summary: Research on Drosophila has revealed that the electrical properties of clock neurons play a crucial role in the temporal coordination of circadian behaviors, with the Ih channel being essential for communication between neurons and behavioral effects.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Immunology
Thanh-Nhan Nguyen, Ghizal Siddiqui, Nicholas A. Veldhuis, Daniel P. Poole
Summary: Transient receptor potential vanilloid 4 (TRPV4) is a mechanosensitive ion channel that regulates macrophage activity and phenotype, influencing immune response and inflammatory diseases. While TRPV4 is generally considered pro-inflammatory, it may also have anti-inflammatory effects. However, the detailed mechanisms of TRPV4 in inflammatory diseases are still limited.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Manuel Rueda, Roberto Ariosa, Mauricio Moldes, Jordi Rambla
Summary: Beacon v2 is an API specification that defines a standard for federated discovery of genomic and phenotypic data. B2RI is a set of open-source software tools that allow quick setup of a local Beacon instance.
Article
Biology
Stefanny Villalobos-Cantor, Ruth M. Barrett, Alec F. Condon, Alicia Arreola-Bustos, Kelsie M. Rodriguez, Michael S. Cohen, Ian Martin
Summary: Controlled protein synthesis is crucial for regulating gene expression in a cell type-specific manner. We developed a new method to specifically label and visualize newly-synthesized proteins in targeted cell populations in the fly brain, allowing for quantitative analysis of protein synthesis states in vivo.
Article
Neurosciences
Zarion D. Marshall, Ellie S. Heckscher
Summary: Proper assembly of somatosensory circuits is crucial for processing somatosensory stimuli and responding accordingly. However, the understanding of somatosensory circuit development is lagging behind that of other sensory systems. In this study, the researchers examined a specific type of somatosensory interneuron in fruit fly larvae and found that the transcription factor Even-skipped (Eve) plays multiple roles in neuron morphogenesis and the encoding of somatosensory stimuli. The findings shed light on the genetic regulation of somatosensory circuit assembly.
Article
Biology
Wanyue Wang, Hany K. M. Dweck, Gaelle J. S. Talross, Ali Zaidi, Joshua M. Gendron, John R. Carlson
Summary: This study explores the differences in sensation and taste between the agricultural pest Drosophila suzukii and other Drosophila species, and finds that D. suzukii has undergone various changes in sweet taste sensation and mechanosensation, which are likely to contribute to its differences in egg-laying preferences.
Article
Cell Biology
Yaopeng Hu, Qin Li, Lin-Hai Kurahara, Narumi Shioi, Keizo Hiraishi, Takayuki Fujita, Xin Zhu, Ryuji Inoue
Summary: The E7K mutation in the TRPM4 channel enhances channel function by altering its interaction with endogenous PIP2, potentially contributing to its arrhythmogenic potential.
Article
Cell Biology
Tai-Ting Lee, Po-Lin Chen, Matthew P. Su, Jian-Chiuan Li, Yi-Wen Chang, Rei-Wen Liu, Hsueh-Fen Juan, Jinn-Moon Yang, Shih-Peng Chan, Yu-Chen Tsai, Sophia von Stockum, Elena Ziviani, Azusa Kamikouchi, Horng-Dar Wang, Chun-Hong Chen
Summary: By using the Drosophila melanogaster model, researchers discovered that the mitochondrial outer membrane protein Fis1 plays a crucial role in muscle dysfunction and several age-related conditions, with mutations leading to damaged mitochondria, increased oxidative stress, and decreased muscle function. Mutations in Fis1 also affect mitochondrial proteostasis in fly muscle, reducing flight capabilities and lifespan, indicating the significance of Fis1 in fly mitochondrial dynamics.
Article
Pharmacology & Pharmacy
Qi Jia, Weifeng Tian, Binbin Li, Wen Chen, Wenjie Zhang, Yang Xie, Na Cheng, Qi Chen, Jianru Xiao, Yiwang Zhang, Jian Yang, Shu Wang
Summary: The activation of TRPV1 and TRPA1 channels plays a key role in melanogenesis, helping melanocytes receive extrinsic and intrinsic signals for pigment production. Inhibition of TRPV1 and TRPA1 channels leads to reduced melanin content in melanoma cells, highlighting their potential as therapeutic targets for pigmentary disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Zijing Chen, Maggie Kerwin, Orlaith Keenan, Craig Montell
Summary: This study identified the structural requirements for TRP channel function in Drosophila photoreceptor cells, including the roles of the S4-S5 linker and the TRP domain, as well as the differential requirements for two highly conserved motifs in the TRP domain for activation and protein stability. Genetic complementation experiments revealed an intrasubunit interaction between the S4-S5 linker and the S5 segment in Drosophila photoreceptor cells, which contributes to channel activation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Alexander Beliveau, Gawain Thomas, Jiaxin Gong, Qi Wen, Anjana Jain
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Bin Liang, Bao-Yu Duan, Xiu-Ping Zhou, Jia-Xin Gong, Zhen-Ge Luo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Multidisciplinary Sciences
Kaiyu Wang, Jiaxin Gong, Qingxiu Wang, Hao Li, Qi Cheng, Yafeng Liu, Shaoqun Zeng, Zuoren Wang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Neurosciences
Yuanquan Song, Dan Li, Olivia Farrelly, Leann Miles, Feng Li, Sung Eun Kim, Tsz Y. Lo, Fei Wang, Tun Li, Katherine L. Thompson-Peer, Jiaxin Gong, Swetha E. Murthy, Bertrand Coste, Nikita Yakubovich, Ardem Patapoutian, Yang Xiang, Panteleimon Rompolas, Lily Yeh Jan, Yuh Nung Jan
Article
Biochemistry & Molecular Biology
Pengyu Gu, Jiaxin Gong, Ye Shang, Fei Wang, Kendra T. Ruppell, Zhiguo Ma, Amy E. Sheehan, Marc R. Freeman, Yang Xiang
Article
Multidisciplinary Sciences
Pengyu Gu, Fei Wang, Ye Shang, Jingjing Liu, Jiaxin Gong, Wei Xie, Junhai Han, Yang Xiang
Summary: Acute nociception and tissue injury-induced hypersensitivity involve distinct cellular and molecular mechanisms in Drosophila larvae. TrpA1-D mediates acute heat nociception, while TrpA1-C transduces the heat stimulus under the allodynia state. Gq-phospholipase C signaling differentially modulates these isoforms in brain neurons, selectively sensitizing heat responses of TrpA1-C.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Jiaxin Gong, Jiazhang Chen, Pengyu Gu, Ye Shang, Kendra Takle Ruppell, Ying Yang, Fei Wang, Qi Wen, Yang Xiang
Summary: This study investigates nocifensive behavior in Drosophila larvae and reveals the critical role of shear stress in activating nociceptors. The study also identifies TRPA1 as a mechanosensitive channel specifically activated by shear stress.