Enemy or ally? Fasting as an essential regulator of immune responses

IL-17 controls central nervous system autoimmunity through the intestinal microbiome

(2021) Tommy Regen et al.   Science Immunology

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

(2020) Adrian F. Gombart et al.   Nutrients

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

(2020) Qi Yan Ang et al.   CELL

Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation

(2020) Fotios Karagiannis et al.   IMMUNITY

CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis

(2020) Isa Santos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Skeletal Muscle Wasting During Cachexia

(2020) Justine M. Webster et al.   Frontiers in Physiology

Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment

(2020) Francesca Pistollato et al.   SEMINARS IN CANCER BIOLOGY

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System

(2019) David C. Nieman et al.   Annual Review of Food Science and Technology

Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet

(2019) Haris Younas et al.   Scientific Reports

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

(2019) Kirthana Ganeshan et al.   CELL

CD8+ T cells induce cachexia during chronic viral infection

(2019) Hatoon Baazim et al.   NATURE IMMUNOLOGY

Trial watch: dietary interventions for cancer therapy

(2019) Sarah Lévesque et al.   OncoImmunology

Targeting Glucose Metabolism to Enhance Immunotherapy: Emerging Evidence on Intermittent Fasting and Calorie Restriction Mimetics

(2019) William J. Turbitt et al.   Frontiers in Immunology

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

(2019) Motoyoshi Nagai et al.   CELL

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

(2019) Nicholas Collins et al.   CELL

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

(2019) Stefan Jordan et al.   CELL

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions

(2019) Junki Miyamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketogenic diet activates protective γδ T cell responses against influenza virus infection

(2019) Emily L. Goldberg et al.   Science Immunology

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development

(2019) Huafeng Zhang et al.   NATURE CELL BIOLOGY

Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice

(2019) Carla Igual Gil et al.   Scientific Reports

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

(2018) Francesca Cignarella et al.   Cell Metabolism

A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics

(2018) Kim Han et al.   JOURNAL OF IMMUNOLOGY

Time-restricted feeding influences immune responses without compromising muscle performance in older men

(2018) Maha Gasmi et al.   NUTRITION

Innate lymphoid cells—key immune integrators of overall body homeostasis

(2018) Fotios Karagiannis et al.   Seminars in Immunopathology

Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen

(2018) Karina K. Sanchez et al.   CELL

Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis

(2018) Patrycja Puchalska et al.   Cell Metabolism

Glucose metabolism mediates disease tolerance in cerebral malaria

(2018) Andrew Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Research: New Perspectives on the Biology of Aging

(2017) Rozalyn M Anderson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells

(2017) Ruihua Ma et al.   NATURE CELL BIOLOGY

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Metabolic Regulation of Innate Lymphoid Cell-Mediated Tissue Protection—Linking the Nutritional State to Barrier Immunity

(2017) Christoph Wilhelm et al.   Frontiers in Immunology

Resource conflict and cooperation between human host and gut microbiota: implications for nutrition and health

(2016) Helen Wasielewski et al.   Annals of the New York Academy of Sciences

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

(2016) Andrew Wang et al.   CELL

Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection

(2016) Christoph Wilhelm et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Immune Dysfunction as a Cause and Consequence of Malnutrition

(2016) Claire D. Bourke et al.   TRENDS IN IMMUNOLOGY

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

(2016) In Young Choi et al.   Cell Reports

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Nutritional control of immunity: Balancing the metabolic requirements with an appropriate immune function

(2015) Veronica De Rosa et al.   SEMINARS IN IMMUNOLOGY

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

(2014) Chia-Wei Cheng et al.   Cell Stem Cell

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Modulation of T Cell and Innate Immune Responses by Retinoic Acid

(2014) M. Raverdeau et al.   JOURNAL OF IMMUNOLOGY

Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

(2014) S. P. Spencer et al.   SCIENCE

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

(2014) Mahbubur Rahman et al.   Nature Communications

Diet-induced weight loss in obese children with asthma: a randomized controlled trial

(2013) M. E. Jensen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Immune System as a Sensor of the Metabolic State

(2013) Justin I. Odegaard et al.   IMMUNITY

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota

(2012) N. Kamada et al.   SCIENCE

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

The ketogenic diet: metabolic influences on brain excitability and epilepsy

(2012) Andrew Lutas et al.   TRENDS IN NEUROSCIENCES

Lipid homeostasis, lipotoxicity and the metabolic syndrome

(2009) Roger H. Unger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cytokine, Sickness Behavior, and Depression

(2009) Robert Dantzer   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

The Role of Anorexia in Resistance and Tolerance to Infections in Drosophila

(2009) Janelle S. Ayres et al.   PLOS BIOLOGY

Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis

(2008) Laura Piccio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

(2008) Boris Görke et al.   NATURE REVIEWS MICROBIOLOGY