NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axis

Defining a Population of Stem-like Human Prostate Cancer Cells That Can Generate and Propagate Castration-Resistant Prostate Cancer

(2016) X. Chen et al.   CLINICAL CANCER RESEARCH

TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice

(2016) Dinesh Babu Uthaya Kumar et al.   GASTROENTEROLOGY

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer

(2016) Dingxiao Zhang et al.   Nature Communications

Regulation of NANOG in cancer cells

(2015) Shuai Gong et al.   MOLECULAR CARCINOGENESIS

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

(2015) Mark M Pomerantz et al.   NATURE GENETICS

Pluripotency factor Nanog is tumorigenic by deregulating DNA damage response in somatic cells

(2015) J Kim et al.   ONCOGENE

Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple-Negative Breast Cancer

(2015) Praveena S. Thiagarajan et al.   STEM CELLS

Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions

(2015) Collene R. Jeter et al.   STEM CELLS

Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells

(2015) Xin Liu et al.   Oncotarget

CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells

(2015) Norihiko Kawamura et al.   Oncotarget

Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy

(2014) Alvaro Aytes et al.   CANCER CELL

NFI Transcription Factors Interact with FOXA1 to Regulate Prostate-Specific Gene Expression

(2014) Magdalena M. Grabowska et al.   MOLECULAR ENDOCRINOLOGY

Nanog1 in NTERA-2 and Recombinant NanogP8 from Somatic Cancer Cells Adopt Multiple Protein Conformations and Migrate at Multiple M.W Species

(2014) Bigang Liu et al.   PLoS One

The pluripotency factor Nanog is directly upregulated by the Androgen Receptor in prostate cancer cells

(2014) Steven Kregel et al.   PROSTATE

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia

(2014) Daniela Piazzolla et al.   Nature Communications

Androgen Receptor-Independent Function of FoxA1 in Prostate Cancer Metastasis

(2013) H.-J. Jin et al.   CANCER RESEARCH

In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals

(2013) Mark A Badeaux et al.   CELL CYCLE

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer

(2013) A R Palla et al.   ONCOGENE

Sox2 Is an Androgen Receptor-Repressed Gene That Promotes Castration-Resistant Prostate Cancer

(2013) Steven Kregel et al.   PLoS One

Understanding cancer stem cell heterogeneity and plasticity

(2012) Dean G Tang   CELL RESEARCH

The PSA−/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration

(2012) Jichao Qin et al.   Cell Stem Cell

Distinct Lineage Specification Roles for NANOG, OCT4, and SOX2 in Human Embryonic Stem Cells

(2012) Zheng Wang et al.   Cell Stem Cell

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

NANOG modulates stemness in human colorectal cancer

(2012) J Zhang et al.   ONCOGENE

FOXA1 Promotes Tumor Progression in Prostate Cancer and Represents a Novel Hallmark of Castration-Resistant Prostate Cancer

(2011) Josefine Gerhardt et al.   AMERICAN JOURNAL OF PATHOLOGY

Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1

(2011) Changmeng Cai et al.   CANCER CELL

Definition of a FoxA1 Cistrome That Is Crucial for G1 to S-Phase Cell-Cycle Transit in Castration-Resistant Prostate Cancer

(2011) C. Zhang et al.   CANCER RESEARCH

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

(2011) Terence Kin Wah Lee et al.   Cell Stem Cell

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

(2011) Biswajyoti Sahu et al.   EMBO JOURNAL

Integration of Regulatory Networks by NKX3-1 Promotes Androgen-Dependent Prostate Cancer Survival

(2011) P. Y. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation

(2011) C R Jeter et al.   ONCOGENE

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer

(2009) Qianben Wang et al.   CELL

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics

(2009) Isabelle Bisson et al.   CELL RESEARCH

Functional Evidence that the Self-Renewal GeneNANOGRegulates Human Tumor Development

(2009) Collene R. Jeter et al.   STEM CELLS

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY