Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease
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Title
Liquid–liquid
phase separation of tau: From molecular biophysics to physiology and disease
Authors
Keywords
-
Journal
PROTEIN SCIENCE
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2021-05-01
DOI
10.1002/pro.4093
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Note: Only part of the references are listed.- Interplay between tau and α‐synuclein LLPS
- (2021) Anna Siegert et al. PROTEIN SCIENCE
- Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
- (2021) Simon Alberti et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
- (2021) Erik W Martin et al. NUCLEIC ACIDS RESEARCH
- Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures
- (2021) Xiangze Zeng et al. APL Materials
- Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions
- (2020) Yanxian Lin et al. ACS Chemical Neuroscience
- Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions
- (2020) Jeong-Mo Choi et al. Annual Review of Biophysics
- Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains
- (2020) Tamta Arakhamia et al. CELL
- Granulins modulate liquid–liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43
- (2020) Anukool A. Bhopatkar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy
- (2020) Anastasia C. Murthy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase Separation and Cytotoxicity of Tau are Modulated by Protein Disulfide Isomerase and S-nitrosylation of this Molecular Chaperone
- (2020) Kan Wang et al. JOURNAL OF MOLECULAR BIOLOGY
- Sequence-based determinants and prediction of fuzzy interactions in protein complexes
- (2020) Marton Miskei et al. JOURNAL OF MOLECULAR BIOLOGY
- NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1
- (2020) Leo E. Wong et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural Characterization of Tau in Fuzzy Tau:Tubulin Complexes
- (2020) Ho Yee Joyce Fung et al. STRUCTURE
- Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice
- (2020) Marangelie Criado-Marrero et al. Cells
- Biomolecular Phase Separation: From Molecular Driving Forces to Macroscopic Properties
- (2020) Gregory L. Dignon et al. Annual Review of Physical Chemistry
- Zinc promotes liquid–liquid phase separation of tau protein
- (2020) Virender Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Liquid–liquid phase separation of type II diabetes-associated IAPP initiates hydrogelation and aggregation
- (2020) Lior Pytowski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics
- (2020) Sarah A. Kent et al. ACTA NEUROPATHOLOGICA
- α-Synuclein aggregation nucleates through liquid–liquid phase separation
- (2020) Soumik Ray et al. Nature Chemistry
- Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
- (2020) Simon Dujardin et al. NATURE MEDICINE
- RNA contributions to the form and function of biomolecular condensates
- (2020) Christine Roden et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Liquid-liquid phase separation induces pathogenic tau conformations in vitro
- (2020) Nicholas M. Kanaan et al. Nature Communications
- Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates
- (2020) Adriana Savastano et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Liquid–Liquid Phase Separation in Crowded Environments
- (2020) Alain A. M. André et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The proline-rich domain promotes Tau liquid–liquid phase separation in cells
- (2020) Xuemei Zhang et al. JOURNAL OF CELL BIOLOGY
- Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau
- (2020) Yanxian Lin et al. JOURNAL OF MOLECULAR BIOLOGY
- Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation
- (2020) Solomiia Boyko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau: It’s Not What You Think
- (2019) Peter W. Baas et al. TRENDS IN CELL BIOLOGY
- Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
- (2019) Simon Alberti et al. CELL
- Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions
- (2019) Solomiia Boyko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
- (2019) Yanxian Lin et al. eLife
- Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases
- (2019) Wenjuan Zhang et al. eLife
- Microtubule nucleation in the cytoplasm of developing cortical neurons and its regulation by brain‐derived neurotrophic factor
- (2019) Mimori Yamada et al. Cytoskeleton
- Liquid–Liquid Phase Separation Is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules
- (2019) Anupa Majumdar et al. Journal of Physical Chemistry Letters
- Molecular interactions underlying liquid−liquid phase separation of the FUS low-complexity domain
- (2019) Anastasia C. Murthy et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Biomolecular condensation of the microtubule-associated protein tau
- (2019) Tina Ukmar-Godec et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Lysine/RNA-interactions drive and regulate biomolecular condensation
- (2019) Tina Ukmar-Godec et al. Nature Communications
- BIN1 favors the spreading of Tau via extracellular vesicles
- (2019) Andrea Crotti et al. Scientific Reports
- USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells
- (2019) Svetlana Piatnitskaia et al. Scientific Reports
- Microtubules gate tau condensation to spatially regulate microtubule functions
- (2019) Ruensern Tan et al. NATURE CELL BIOLOGY
- Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes
- (2019) Valerie Siahaan et al. NATURE CELL BIOLOGY
- EFhd2 Affects Tau Liquid–Liquid Phase Separation
- (2019) Irving E. Vega et al. Frontiers in Neuroscience
- The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins
- (2019) Izzy Owen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intrinsically disordered proteins access a range of hysteretic phase separation behaviors
- (2019) Felipe Garcia Quiroz et al. Science Advances
- Intermolecular Charge-Transfer Modulates Liquid–Liquid Phase Separation and Liquid-to-Solid Maturation of an Intrinsically Disordered pH-Responsive Domain
- (2019) Priyanka Dogra et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits
- (2018) Ramon Velazquez et al. AGING CELL
- Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions
- (2018) Erik W. Martin et al. BIOCHEMISTRY
- A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
- (2018) Jie Wang et al. CELL
- Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
- (2018) Ke Zhang et al. CELL
- Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains
- (2018) Liang Qiang et al. CURRENT BIOLOGY
- Tau protein liquid–liquid phase separation can initiate tau aggregation
- (2018) Susanne Wegmann et al. EMBO JOURNAL
- Acetylation Disfavors Tau Phase Separation
- (2018) Josephine Ferreon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Microtubules as platforms for probing liquid–liquid phase separation in cells – application to RNA-binding proteins
- (2018) Alexandre Maucuer et al. JOURNAL OF CELL SCIENCE
- Advances in Understanding Stimulus-Responsive Phase Behavior of Intrinsically Disordered Protein Polymers
- (2018) Kiersten M. Ruff et al. JOURNAL OF MOLECULAR BIOLOGY
- Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation
- (2018) Veronica H. Ryan et al. MOLECULAR CELL
- Microtubule dynamics: an interplay of biochemistry and mechanics
- (2018) Gary J. Brouhard et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Protein Phase Separation: A New Phase in Cell Biology
- (2018) Steven Boeynaems et al. TRENDS IN CELL BIOLOGY
- Pi-Pi contacts are an overlooked protein feature relevant to phase separation
- (2018) Robert McCoy Vernon et al. eLife
- The molecular language of membraneless organelles
- (2018) Edward Gomes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structures of filaments from Pick’s disease reveal a novel tau protein fold
- (2018) Benjamin Falcon et al. NATURE
- Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease
- (2018) Bahareh Eftekharzadeh et al. NEURON
- RNA binding proteins co-localize with small tau inclusions in tauopathy
- (2018) Brandon F. Maziuk et al. Acta Neuropathologica Communications
- Phospho-Tau Impairs Nuclear-Cytoplasmic Transport
- (2018) Timir Tripathi et al. ACS Chemical Neuroscience
- Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology
- (2018) Joana Margarida Silva et al. CELL DEATH AND DIFFERENTIATION
- Acetylation of intrinsically disordered regions regulates phase separation
- (2018) Makoto Saito et al. Nature Chemical Biology
- Tau monomer encodes strains
- (2018) Apurwa M Sharma et al. eLife
- Tau’s Three-Repeat Domain and EFhd2 Co-incubation Leads to Increased Thioflavin Signal
- (2018) Irving E. Vega et al. Frontiers in Neuroscience
- Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain
- (2017) Sneha Narasimhan et al. JOURNAL OF NEUROSCIENCE
- Phosphoregulation of Tau modulates inhibition of kinesin-1 motility
- (2017) Jamie L. Stern et al. MOLECULAR BIOLOGY OF THE CELL
- Cryo-EM structures of tau filaments from Alzheimer’s disease
- (2017) Anthony W. P. Fitzpatrick et al. NATURE
- Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
- (2017) Daniel J. Apicco et al. NATURE NEUROSCIENCE
- Biomolecular condensates: organizers of cellular biochemistry
- (2017) Salman F. Banani et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer’s disease
- (2017) Yuan Zhang et al. REVIEWS IN THE NEUROSCIENCES
- Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams
- (2017) Abdullah R. Chaudhary et al. TRAFFIC
- Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
- (2017) Yunior Cabrales Fontela et al. Nature Communications
- Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
- (2017) Susmitha Ambadipudi et al. Nature Communications
- Tau association with synaptic vesicles causes presynaptic dysfunction
- (2017) Lujia Zhou et al. Nature Communications
- Signature of an aggregation-prone conformation of tau
- (2017) Neil A. Eschmann et al. Scientific Reports
- Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
- (2017) Amayra Hernández-Vega et al. Cell Reports
- RNA stores tau reversibly in complex coacervates
- (2017) Xuemei Zhang et al. PLOS BIOLOGY
- Tau and tauopathies
- (2016) Thomas Arendt et al. BRAIN RESEARCH BULLETIN
- ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure
- (2016) Saumya Jain et al. CELL
- Phase separation in biology; functional organization of a higher order
- (2016) Diana M. Mitrea et al. Cell Communication and Signaling
- The Multiple Faces of Disordered Nucleoporins
- (2016) Edward A. Lemke JOURNAL OF MOLECULAR BIOLOGY
- Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation
- (2016) Erik W. Martin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein
- (2016) Chi W. Pak et al. MOLECULAR CELL
- Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo
- (2016) Sarah K. Kaufman et al. NEURON
- A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression
- (2016) Benedetta Bolognesi et al. Cell Reports
- Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
- (2016) Tara Vanderweyde et al. Cell Reports
- Folding of the Tau Protein on Microtubules
- (2015) Harindranath Kadavath et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- CIDER: Classification of Intrinsically Disordered Ensemble Regions
- (2015) Alex S. Holehouse et al. BIOPHYSICAL JOURNAL
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
- (2015) Avinash Patel et al. CELL
- Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
- (2015) Yuan Lin et al. MOLECULAR CELL
- Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
- (2015) Timothy J. Nott et al. MOLECULAR CELL
- Polymer physics of intracellular phase transitions
- (2015) Clifford P. Brangwynne et al. Nature Physics
- Intrinsically disordered proteins in cellular signalling and regulation
- (2015) Peter E. Wright et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Tau in physiology and pathology
- (2015) Yipeng Wang et al. NATURE REVIEWS NEUROSCIENCE
- Building the Neuronal Microtubule Cytoskeleton
- (2015) Lukas C. Kapitein et al. NEURON
- Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
- (2015) Harindranath Kadavath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Impact of Tau Phosphorylation at Threonine 231
- (2015) Martin Schwalbe et al. STRUCTURE
- Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein
- (2014) Amina Kamah et al. BIOCHEMISTRY
- Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy
- (2014) Malene Ringkjøbing Jensen et al. CHEMICAL REVIEWS
- Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
- (2014) David W. Sanders et al. NEURON
- Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2
- (2013) Martin Schwalbe et al. BIOCHEMISTRY
- EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease
- (2013) Yancy Ferrer-Acosta et al. JOURNAL OF NEUROCHEMISTRY
- Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
- (2013) David J. Irwin et al. NATURE REVIEWS NEUROSCIENCE
- Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues
- (2013) R. K. Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predictive Atomic Resolution Descriptions of Intrinsically Disordered hTau40 and α-Synuclein in Solution from NMR and Small Angle Scattering
- (2013) Martin Schwalbe et al. STRUCTURE
- Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain
- (2013) Ayaho Dan et al. Acta Neuropathologica Communications
- Tau protein kinases: Involvement in Alzheimer's disease
- (2012) Ludovic Martin et al. AGEING RESEARCH REVIEWS
- Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes
- (2012) Aksana A Labokha et al. EMBO JOURNAL
- Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies
- (2012) T. Vanderweyde et al. JOURNAL OF NEUROSCIENCE
- Regulated protein aggregation: stress granules and neurodegeneration
- (2012) Benjamin Wolozin Molecular Neurodegeneration
- Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF
- (2012) Qian Chen et al. NEUROCHEMISTRY INTERNATIONAL
- Intrinsically disordered proteins: a 10-year recap
- (2012) Peter Tompa TRENDS IN BIOCHEMICAL SCIENCES
- Single Molecule Study of the Intrinsically Disordered FG-Repeat Nucleoporin 153
- (2011) Sigrid Milles et al. BIOPHYSICAL JOURNAL
- Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau
- (2011) Alessia Usardi et al. FEBS Journal
- Understanding the Kinetic Roles of the Inducer Heparin and of Rod-like Protofibrils during Amyloid Fibril Formation by Tau Protein
- (2011) Gayathri Ramachandran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport
- (2011) Nicholas M. Kanaan et al. NEUROBIOLOGY OF AGING
- Post-translational modifications of tau protein: Implications for Alzheimer's disease
- (2011) Ludovic Martin et al. NEUROCHEMISTRY INTERNATIONAL
- The Many Faces of Tau
- (2011) Meaghan Morris et al. NEURON
- The acetylation of tau inhibits its function and promotes pathological tau aggregation
- (2011) Todd J. Cohen et al. Nature Communications
- PONDR-FIT: A meta-predictor of intrinsically disordered amino acids
- (2010) Bin Xue et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression
- (2010) Elena Gómez de Barreda et al. FEBS LETTERS
- Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
- (2010) Lars M. Ittner et al. NATURE REVIEWS NEUROSCIENCE
- Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
- (2010) Sang-Won Min et al. NEURON
- Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
- (2010) Brian R. Hoover et al. NEURON
- Microtubule-severing enzymes
- (2009) Antonina Roll-Mecak et al. CURRENT OPINION IN CELL BIOLOGY
- Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
- (2009) C. Choudhary et al. SCIENCE
- Structural Polymorphism of 441-Residue Tau at Single Residue Resolution
- (2009) Marco D Mukrasch et al. PLOS BIOLOGY
- Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease
- (2008) C.-X. Gong et al. CURRENT MEDICINAL CHEMISTRY
- Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin
- (2008) Inmaculada Cuchillo-Ibanez et al. FASEB JOURNAL
- A novel calcium-binding protein is associated with tau proteins in tauopathy
- (2008) Irving E. Vega et al. JOURNAL OF NEUROCHEMISTRY
- The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity
- (2008) Nichole E. LaPointe et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The Microtubule-severing Proteins Spastin and Katanin Participate Differently in the Formation of Axonal Branches
- (2008) Wenqian Yu et al. MOLECULAR BIOLOGY OF THE CELL
- Microtubule-associated protein tau in development, degeneration and protection of neurons
- (2008) Jian-Zhi Wang et al. PROGRESS IN NEUROBIOLOGY
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