Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidences and future perspectives

Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review

(2020) Mahshid Moballegh Nasery et al.   MOLECULES

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

(2020) Amit S. Choudhari et al.   Frontiers in Pharmacology

Caffeine and its main targets of colorectal cancer

(2020) Wen-Qi Cui et al.   World Journal of Gastrointestinal Oncology

Gamma irradiation promotes chemo-sensitization potential of gallic acid through attenuation of autophagic flux to trigger apoptosis in NRF2 inactivation signalling pathway

(2020) Srimanta Patra et al.   FREE RADICAL BIOLOGY AND MEDICINE

ER-mitochondria interactions: Both strength and weakness within cancer cells

(2019) Mabrouka Doghman-Bouguerra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting autophagy using natural compounds for cancer prevention and therapy

(2019) Shuo Deng et al.   CANCER

Autophagy as a molecular target for cancer treatment

(2019) Nur Mehpare Kocaturk et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The effect of medicinal plants on multiple drug resistance through autophagy: A review of in vitro studies

(2019) Elham Sameiyan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism

(2019) Marjorie Reyes-Farias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kaempferol: A Key Emphasis to Its Anticancer Potential

(2019) Muhammad Imran et al.   MOLECULES

Plant lectins in cancer therapeutics: Targeting apoptosis and autophagy-dependent cell death

(2019) Sujit K. Bhutia et al.   PHARMACOLOGICAL RESEARCH

Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells

(2019) Chieh-Yu Lan et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Terminalia bellirica extract induces anticancer activity through modulation of apoptosis and autophagy in oral squamous cell carcinoma

(2019) Srimanta Patra et al.   FOOD AND CHEMICAL TOXICOLOGY

Bioavailability enhancement of EGCG by structural modification and nano-delivery: A review

(2019) Wenzhong Dai et al.   Journal of Functional Foods

Phytochemicals as potent modulators of autophagy for cancer therapy

(2018) Mohammad Amin Moosavi et al.   CANCER LETTERS

Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention

(2018) Devesh Tewari et al.   PHARMACOLOGICAL RESEARCH

A new promising way of maintenance therapy in advanced ovarian cancer: a comparative clinical study

(2018) Vsevolod I. Kiselev et al.   BMC CANCER

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Curcumin: A naturally occurring autophagy modulator

(2018) Abolfazl Shakeri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bioavailability of Tea Catechins and Its Improvement

(2018) Zhuo-Yu Cai et al.   MOLECULES

Apigenin: A natural bioactive flavone-type molecule with promising therapeutic function

(2018) Dharambir Kashyap et al.   Journal of Functional Foods

Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involved

(2018) Sadia Afrin et al.   BIOTECHNOLOGY ADVANCES

Autophagy and its potent modulators from phytochemicals in cancer treatment

(2018) Chao-Yue Sun et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells

(2017) Ching-Yi Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Resveratrol in Cancer Therapy

(2017) Jeong-Hyeon Ko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

(2017) Liviuta Budisan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling

(2017) Chao-Hsiang Chang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway

(2017) Hanyang Liu et al.   Molecular Medicine Reports

Curcumin induced autophagy anticancer effects on human lung adenocarcinoma cell line A549

(2017) Furong Liu et al.   Oncology Letters

Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line

(2017) Laura Masuelli et al.   Oncotarget

Emerging importance of dietary phytochemicals in fight against cancer: Role in targeting cancer stem cells

(2016) Amit Kumar Singh et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission

(2016) Haili Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Autophagy modulators from traditional Chinese medicine: Mechanisms and therapeutic potentials for cancer and neurodegenerative diseases

(2016) Sheng-Fang Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis

(2016) Patrick Antonietti et al.   MOLECULAR CANCER THERAPEUTICS

New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

(2016) Betty Law et al.   MOLECULES

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

(2016) Seung Ho Baek et al.   PHYTOMEDICINE

Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy

(2015) Jun He et al.   Autophagy

Cancer Therapy with Phytochemicals: Present and Future Perspectives

(2015) Muobarak J. Tuorkey   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models

(2015) Eric Hervouet et al.   BMC CANCER

Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy

(2015) Xiaoyun Dai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art

(2015) Mohammad Zaki Ahmad et al.   JOURNAL OF DRUG TARGETING

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of phytochemicals in colorectal cancer prevention

(2015) Yu-Hua Li   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model

(2015) Ruthrotha B. Selvi et al.   Oncotarget

Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-Gingerol in cervical cancer cells

(2015) Namrata Rastogi et al.   Oncotarget

Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death

(2015) Miho Akimoto et al.   PLoS One

Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells

(2015) Fangfang Lang et al.   PLoS One

Non-canonical autophagy: An exception or an underestimated form of autophagy?

(2014) Francesca Scarlatti et al.   Autophagy

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

(2014) Ugur Akar et al.   Autophagy

Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells

(2014) YUJIN LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Dietary antiaging phytochemicals and mechanisms associated with prolonged survival

(2014) Hongwei Si et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Combined treatment with quercetin and imperatorin as a potent strategy for killing HeLa and Hep-2 cells

(2014) Dorota Bądziul et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling

(2014) EK Radhakrishnan et al.   PLoS One

Anticancer Activity of a Broccoli Derivative, Sulforaphane, in Barrett Adenocarcinoma: Potential Use in Chemoprevention and as Adjuvant in Chemotherapy

(2014) Aamer Qazi et al.   Translational Oncology

Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

(2014) N Hasima et al.   Cell Death & Disease

WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells

(2014) D Brigger et al.   Cell Death & Disease

Tumor Suppression and Promotion by Autophagy

(2014) Yenniffer Ávalos et al.   Biomed Research International

Free Radicals in Cross Talk Between Autophagy and Apoptosis

(2013) Vitaliy O. Kaminskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells

(2013) Shin-Hyung Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells

(2013) WEN-WEN HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Molecular Approaches Toward Targeted Cancer Prevention with Some Food Plants and Their Products: Inflammatory and Other Signal Pathways

(2013) Anisur Rahman Khuda-Bukhsh et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Quercetin Induces Mitochondrial Mediated Apoptosis and Protective Autophagy in Human Glioblastoma U373MG Cells

(2013) Hyeonji Kim et al.   Oxidative Medicine and Cellular Longevity

PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity

(2013) Rajaa Errafiy et al.   PLoS One

Activation of ERK signaling and induction of colon cancer cell death by piperlongumine

(2013) H. Randhawa et al.   TOXICOLOGY IN VITRO

Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells

(2013) Kai Sun et al.   Cell and Bioscience

Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials

(2012) Fernando Torres Andón et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME

(2012) Zhen Yang et al.   Anti-Cancer Agents in Medicinal Chemistry

Fisetin: A Dietary Antioxidant for Health Promotion

(2012) Naghma Khan et al.   ANTIOXIDANTS & REDOX SIGNALING

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Autophagic lysosome reformation

(2012) Yang Chen et al.   EXPERIMENTAL CELL RESEARCH

Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells

(2012) HISANORI MIKI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy

(2012) Grazyna Mosieniak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone

(2012) H.-Q. Li et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Colorectal cancer chemoprevention by trans-resveratrol

(2012) M. Emília Juan et al.   PHARMACOLOGICAL RESEARCH

Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling

(2011) Kui Wang et al.   Autophagy

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Autophagy modulation for cancer therapy

(2011) Zhineng J. Yang et al.   CANCER BIOLOGY & THERAPY

Resveratrol, a Phytochemical Inducer of Multiple Cell Death Pathways: Apoptosis, Autophagy and Mitotic Catastrophe

(2011) D. Delmas et al.   CURRENT MEDICINAL CHEMISTRY

The dual role of autophagy in cancer

(2011) Eeva-Liisa Eskelinen   CURRENT OPINION IN PHARMACOLOGY

Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy

(2011) Chien-Ju Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity

(2011) Anja K. Klappan et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Involvement of ROS in Curcumin-induced Autophagic Cell Death

(2011) Youn Ju Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Targeting autophagy during cancer therapy to improve clinical outcomes

(2011) Jean M. Mulcahy Levy et al.   PHARMACOLOGY & THERAPEUTICS

Autophagy is a therapeutic target in anticancer drug resistance

(2010) Suning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells

(2010) Y. Suh et al.   CARCINOGENESIS

Lesson Learned from Nature for the Development of Novel Anti-Cancer Agents: Implication of Isoflavone, Curcumin, and their Synthetic Analogs

(2010) Fazlul H. Sarkar et al.   CURRENT PHARMACEUTICAL DESIGN

Resveratrol Arrests Cell Cycle and Induces Apoptosis in Human Hepatocellular Carcinoma Huh-7 Cells

(2010) Pei-Chi Liao et al.   JOURNAL OF MEDICINAL FOOD

The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

(2010) V. Voss et al.   MOLECULAR CANCER RESEARCH

Phytochemicals in Cancer Prevention and Therapy: Truth or Dare?

(2010) Maria Russo et al.   Toxins

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells

(2009) Cristina P.R. Xavier et al.   CANCER LETTERS

Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials

(2009) A. Bishayee   Cancer Prevention Research

Cellular and sub-cellular responses to UVA in relation to carcinogenesis

(2009) Andrew J. Ridley et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

6-Shogaol, an Active Constituent of Dietary Ginger, Induces Autophagy by Inhibiting the AKT/mTOR Pathway in Human Non-Small Cell Lung Cancer A549 Cells

(2009) Jen-Yu Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Perspectives for Cancer Prevention With Natural Compounds

(2009) A.R.M. Ruhul Amin et al.   JOURNAL OF CLINICAL ONCOLOGY

Bioavailability and Delivery of Nutraceuticals Using Nanotechnology

(2009) Qingrong Huang et al.   JOURNAL OF FOOD SCIENCE

Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells

(2009) Eun Jeong Choi et al.   Nutrition Research and Practice

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions

(2009) M Reis-Sobreiro et al.   ONCOGENE

Diet, Autophagy, and Cancer: A Review

(2008) K. Singletary et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION