Blockage of the JAK/STAT3 signaling pathway in multiple myeloma by leelamine

The multifaceted role of reactive oxygen species in tumorigenesis

(2020) Anuradha Kirtonia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature

(2020) Chakrabhavi Dhananjaya Mohan et al.   SEMINARS IN CANCER BIOLOGY

Vitexin abrogates invasion and survival of hepatocellular carcinoma cells through targeting STAT3 signaling pathway

(2020) Jong Hyun Lee et al.   BIOCHIMIE

Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model

(2019) Chulwon Kim et al.   Biomolecules

Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways

(2019) Young Yun Jung et al.   MOLECULES

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer

(2018) Krishna B Singh et al.   MOLECULAR CANCER THERAPEUTICS

Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

(2018) Young Yun Jung et al.   Frontiers in Pharmacology

Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma

(2018) Muthu K. Shanmugam et al.   Frontiers in Pharmacology

Do STAT3 inhibitors have potential in the future for cancer therapy?

(2017) Andrea L.A. Wong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase

(2017) Seung Baek et al.   MOLECULES

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

(2017) Xiaoyun Dai et al.   Oncotarget

Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport

(2017) Raghavendra Gowda et al.   Oncotarget

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

(2016) Seung Ho Baek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation

(2016) Anuradha Sehrawat et al.   MOLECULAR CARCINOGENESIS

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

Analysis of the intricate relationship between chronic inflammation and cancer

(2015) Edna Zhi Pei Chai et al.   BIOCHEMICAL JOURNAL

Future distribution of multiple myeloma in the United States by sex, age, and race/ethnicity

(2015) P. S. Rosenberg et al.   BLOOD

Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway

(2015) Jong Hyun Lee et al.   CANCER LETTERS

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

(2015) Jong Hyun Lee et al.   Oncotarget

Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells

(2014) Sung-Moo Kim et al.   CANCER LETTERS

Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Chakrabhavi Dhananjaya Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leelamine Mediates Cancer Cell Death through Inhibition of Intracellular Cholesterol Transport

(2014) O. F. Kuzu et al.   MOLECULAR CANCER THERAPEUTICS

Cancer mortality in Europe, 2005–2009, and an overview of trends since 1980

(2013) C. Bosetti et al.   ANNALS OF ONCOLOGY

β-caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase

(2013) Chulwon Kim et al.   MOLECULAR CARCINOGENESIS

STAT3 Phosphorylation at Tyrosine 705 and Serine 727 Differentially Regulates Mouse ESC Fates

(2013) Guanyi Huang et al.   STEM CELLS

Continuous treatment in multiple myeloma: The future?

(2013) Isabelle Vande Broek et al.   TRANSFUSION AND APHERESIS SCIENCE

Bortezomib-induced severe autonomic neuropathy

(2012) A. Stratogianni et al.   CLINICAL AUTONOMIC RESEARCH

Thalidomide-induced acute cholestatic hepatitis: Case report and review of the literature

(2012) Filipe Vilas-Boas et al.   Gastroenterologia y Hepatologia

Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN

(2011) Ji Young Heo et al.   CANCER LETTERS

Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1

(2008) K. S. Ahn et al.   CANCER RESEARCH