Article
Biotechnology & Applied Microbiology
Shuang Zhao, Chengbo Rong, Yi Gao, Linfeng Wu, Xiaoheng Luo, Shuang Song, Yu Liu, Jack Ho Wong, Hexiang Wang, Litao Yi, Tzibun Ng
Summary: A 28-kDa polysaccharide-peptide with antidepressant-like activities was isolated from the spores of Ganoderma lucidum, showing similarities with proteins from other mushroom species. This compound enhanced cell viability, reduced stress hormone levels, and influenced brain neurotransmitters and proteins, suggesting a potential BDNF-dependent mechanism.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexandros Tsimpolis, Maria Kokkali, Aris Logothetis, Konstantinos Kalafatakis, Ioannis Charalampopoulos
Summary: Novel research studies have discovered complex interactions between glucocorticoid hormones and brain-derived neurotrophic factor, regulating crucial physiological processes in neuronal cells. This study investigated the acute effects of glucocorticoid stimulation on gene expression of BDNF and TrkB in astrocytes, revealing a biphasic response characterized by an initial rapid upregulation and subsequent downregulation of BDNF mRNA under the influence of glucocorticoid receptors. These findings demonstrate a rhythmic regulation of the neurotrophin system based on glucocorticoid levels, indicating the intricate trophic responses to temporal hormonal mechanisms in the brain microenvironment.
Article
Biochemistry & Molecular Biology
Yang Yang, Akihiro Mouri, Qiaohui Lu, Kazuo Kunisawa, Hisayoshi Kubota, Masaya Hasegawa, Mami Hirakawa, Yuko Mori, Zou Libo, Kuniaki Saito, Toshitaka Nabeshima
Summary: Lou C and Xan attenuate abnormal behaviors induced by chronic corticosterone administration by increasing BDNF expression and phosphorylation of Akt, mTOR, and CREB, making them attractive candidates for the treatment of depressive disorders.
NEUROCHEMICAL RESEARCH
(2022)
Article
Behavioral Sciences
Mingxiu Chang, Li Zhang, Huiyu Dai, Ling Sun
Summary: The study found that genistein has anti-depression effects by increasing activity levels, improving sucrose preference, reducing cortisol levels, and enhancing the expression of BDNF in the brain tissue of rats.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Lei Li, Tianyu Wang, Suzhen Chen, Yingying Yue, Zhi Xu, Yonggui Yuan
Summary: The study found significantly higher levels of DNA methylation at two CpG sites in BDNF exon VI in patients with major depressive disorder, which were associated with the onset of depression and response to antidepressant treatment, especially in females. These findings suggest that gender-specific alterations in methylation of certain CpG sites in BDNF exon VI may serve as a potential biomarker for MDD and antidepressant-induced remission.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Ji-chun Zhang, Wei Yao, Kenji Hashimoto
Summary: The N-methyl-D-aspartate receptor (NMDAR) antagonist (R,S)-ketamine has been shown to have rapid and sustained antidepressant effects in treatment-resistant patients with major depressive disorder and other psychiatric disorders. However, recent studies suggest that the (R) enantiomer of ketamine may have even stronger and longer-lasting antidepressant effects than the (S) enantiomer. Additionally, the (R) enantiomer has fewer side effects. Ongoing clinical trials aim to further investigate the potential of (R)-ketamine in the treatment of treatment-resistant depression.
Review
Biochemistry & Molecular Biology
Jingjing Piao, Yingwei Wang, Tianqi Zhang, Jiayu Zhao, Qianyu Lv, Mengyu Ruan, Qin Yu, Bingjin Li
Summary: Depression is a mental disorder affecting approximately 350 million individuals globally. Current main treatments, such as medication and psychological therapy, often have limited effectiveness. Nutritional psychiatry, which emphasizes the potential benefits of a balanced diet, is emerging as a promising approach for managing depressive symptoms.
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Hao Hua, Chaoli Huang, Hanyu Liu, Xiangyang Xu, Xiangqing Xu, Zifeng Wu, Cunming Liu, Yuanyuan Wang, Chun Yang
Summary: The discovery of the antidepressant actions of ketamine and its role in regulating the gut microbiome through the microbiota-gut-brain axis is a significant advancement in depression treatment. However, the precise mechanisms underlying these effects are still unclear.
Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Multidisciplinary Sciences
Wei Zheng, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhan, Su-Miao Zhou, Su Yan, Yu-Ping Ning
Summary: The study found that baseline plasma BDNF concentrations appeared to be correlated with ketamine's antidepressant efficacy in Chinese patients with depression. High levels of pBDNF were associated with better treatment outcomes.
Article
Multidisciplinary Sciences
Wei Zheng, Qiaomei Cen, Sha Nie, Minyi Li, Rong Zeng, Sumiao Zhou, Dongbin Cai, Miaoling Jiang, Xiong Huang
Summary: Based on the study of 30 patients with treatment-refractory depression, it was found that serum BDNF levels do not seem to be a reliable biomarker to determine the antidepressant effects of ketamine as an anaesthesia in ECT. Further studies with larger sample sizes are needed to confirm these findings.
Article
Multidisciplinary Sciences
Carlos Berlanga-Macias, Mairena Sanchez-Lopez, Montserrat Solera-Martinez, Ana Diez-Fernandez, Inmaculada Ballesteros-Yanez, Carlos A. Castillo-Sarmiento, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino
Summary: This study found no significant positive association between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren aged eight to 11 years. Regardless of breastfeeding duration, age group, or sexual maturation, BDNF levels did not show significant differences, indicating that exclusive breastfeeding may not have a significant impact on BDNF levels in this age group.
Article
Plant Sciences
Tzu-wen Chou, Huai-Syuan Huang, Suraphan Panyod, Yun-Ju Huang, Lee-Yan Sheen
Summary: Korean red ginseng water extract (KGE) and its active component exhibit antidepressant effects by regulating dopamine, serotonin, and brain-derived neurotrophic factor (BDNF) expression.
JOURNAL OF GINSENG RESEARCH
(2023)
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Article
Immunology
Jianhui Xie, Zhixiu Lin, Yanfang Xian, Songzhi Kong, Zhengquan Lai, Siupo Ip, Haiming Chen, Huizhen Guo, Zuqing Su, Xiaobo Yang, Yang Xu, Ziren Su
INTERNATIONAL IMMUNOPHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Yan-Fang Xian, Ding Fan, Siu-Po Ip, Qing-Qiu Mao, Zhi-Xiu Lin
NEUROCHEMICAL RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Yan-Fang Xian, Siu-Po Ip, Qing-Qiu Mao, Zhi-Xiu Lin
NEUROCHEMISTRY INTERNATIONAL
(2016)
Article
Pharmacology & Pharmacy
Zheng-Quan Lai, Siu-Po Ip, Hui-Jun Liao, Zheng Lu, Jian-Hui Xie, Zi-Ren Su, Yun-Long Chen, Yan-Fang Xian, Po-Sing Leung, Zhi-Xiu Lin
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Medicine, Research & Experimental
Hai-Ming Chen, Zheng-Quan Lai, Hui-Jun Liao, Jian-Hui Xie, Yan-Fang Xian, Yun-Long Chen, Siu-Po Ip, Zhi-Xiu Lin, Zi-Ren Su
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Plant Sciences
Xian Yan-Fang, Hu Zhen, Ip Siu-Po, Chen Jian-Nan, Su Zi-Ren, Lai Xiao-Ping, Lin Zhi-Xiu
Article
Integrative & Complementary Medicine
Hui-Qin Li, Siu-Po Ip, Guo-Qing Zheng, Yan-Fang Xian, Zhi-Xiu Lin
Article
Biochemistry & Molecular Biology
Xiang-Xiao Meng, Yan-Fang Xian, Li Xiang, Dong Zhang, Yu-Hua Shi, Ming-Li Wu, Gang-Qiang Dong, Siu-Po Ip, Zhi-Xiu Lin, Lan Wu, Wei Sun
Review
Pharmacology & Pharmacy
Wen Yang, Siu-Po Ip, Ling Liu, Yan-Fang Xian, Zhi-Xiu Lin
CURRENT VASCULAR PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yan-Fang Xian, Siu-Po Ip, Hui-Qin Li, Chang Qu, Zi-Ren Su, Jian-Nan Chen, Zhi-Xiu Lin
Article
Immunology
Hui-Qin Li, Siu-Po Ip, Qiu-Ju Yuan, Guo-Qing Zheng, Karl K. W. Tsim, Tina T. X. Dong, Ge Lin, Yifan Han, Yue Liu, Yan-Fang Xian, Zhi-Xiu Lin
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Medicine, Research & Experimental
Jian-Hui Xie, Zheng-Quan Lai, Xing-Han Zheng, Yan-Fang Xian, Qian Li, Siu-Po Ip, You-Liang Xie, Jian-Nan Chen, Zi-Ren Su, Zhi-Xiu Lin, Xiao-Bo Yang
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2019)
Article
Immunology
Jinmeng Zhao, Xinyi Niu, Jinjin Yu, Xin Xiao, Wenqi Li, Lulu Zang, Zhen Hu, Paul I. P. Siu-Po, Weifeng Li
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Cell Biology
Yan-Fang Xian, Chang Qu, Yue Liu, Siu-Po Ip, Qiu-Ju Yuan, Wen Yang, Zhi-Xiu Lin
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Plant Sciences
Lan Wang, Zhen Hu, Wen Yang, Steven King Fan Loo, Siu Po Ip, Yan-Fang Xian, Zhi Xiu Lin
Summary: This study developed a modified Huang-Lian-Jie-Du Decoction (MHLJDD) and demonstrated its potential efficacy in treating atopic dermatitis (AD) using mouse models. MHLJDD improved AD-like symptoms, including skin thickening, dryness, and inflammation, and regulated gut microbiota.
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)