The hormetic dose-response mechanism: Nrf2 activation

Demonstrated hormetic mechanisms putatively subserve riluzole-induced effects in neuroprotection against amyotrophic lateral sclerosis (ALS): Implications for research and clinical practice

(2021) Edward J. Calabrese et al.   AGEING RESEARCH REVIEWS

Upregulation of Nrf2- related cytoprotective genes expression by acetaminophen-induced acute hepatotoxicity in mice and the protective role of betaine

(2020) MJ Khodayar et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Hydrogen Sulfide Attenuates Particulate Matter-Induced Emphysema and Airway Inflammation Through Nrf2-Dependent Manner

(2020) Guohua Jia et al.   Frontiers in Pharmacology

The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

(2020) Jing Lu et al.   Frontiers in Pharmacology

Does Green Tea Induce Hormesis?

(2020) Edward J. Calabrese et al.   Dose-Response

Cytoplasmic Radiation Induced Radio-Adaptive Response in Human Lung Fibroblast WI-38 Cells

(2020) Jun Wang et al.   RADIATION RESEARCH

Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells

(2020) Luoyao Yang et al.   Redox Biology

The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis

(2020) Edward J. Calabrese et al.   PHARMACOLOGICAL RESEARCH

Ischemic and hypoxic conditioning: Potential for protection of vital organs

(2019) Justin D. Sprick et al.   EXPERIMENTAL PHYSIOLOGY

(2S)-5,6,7,3′,4′-pentamethoxyflavanone, a citrus polymethoxyflavone ameliorates arsenic- and cigarette smoke extract-induced cytotoxicity via activating Nrf2-mediated defense system

(2019) Ming-Xing Zhou et al.   Journal of Functional Foods

Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway

(2019) Guizhen Zheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of fluoride on PERK-Nrf2 signaling pathway in mouse ameloblasts

(2019) X Zhou et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Methylene blue elicits non-genotoxic H2O2 production and protects brain mitochondria from rotenone toxicity

(2019) Artem P. Gureev et al.   Journal of Applied Biomedicine

TTB Protects Astrocytes Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Activation of Nrf2/HO-1 Signaling Pathway

(2019) Liang Liu et al.   Frontiers in Pharmacology

Protective effect of methylene blue on TNBS-induced colitis in rats mediated through the modulation of inflammatory and apoptotic signalling pathways

(2019) Nesrine S. El Sayed et al.   ARCHIVES OF TOXICOLOGY

Protodioscin protects PC12 cells against oxygen and glucose deprivation-induced injury through miR-124/AKT/Nrf2 pathway

(2019) Kun Shu et al.   CELL STRESS & CHAPERONES

Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells

(2019) Xue-Yi Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis

(2019) Ai-Ling Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells

(2019) Guo-Hui Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway

(2019) Linglu Jia et al.   EXPERIMENTAL CELL RESEARCH

Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks

(2018) Haseeb Khaliq et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells

(2018) Hyewon Moon et al.   Biomolecules & Therapeutics

Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons

(2018) Yasuhiko Izumi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease

(2018) Fangfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Early antioxidant responses via the concerted activation of NF-κB and Nrf2 characterize the gamma-radiation-induced adaptive response in quiescent human peripheral blood mononuclear cells

(2018) Neha Paraswani et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Metabolic Responses in Endothelial Cells Following Exposure to Ketone Bodies

(2018) Erika Meroni et al.   Nutrients

Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells

(2018) Ming-Xing Zhou et al.   Redox Biology

Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway

(2018) Shi-feng Chu et al.   ACTA PHARMACOLOGICA SINICA

Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults

(2018) Yan-Ru Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enhancing and Extending Biological Performance and Resilience

(2018) Rehana K. Leak et al.   Dose-Response

Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson’s disease and inflammatory pathways

(2018) Zubeyir Elmazoglu et al.   DRUG AND CHEMICAL TOXICOLOGY

The effects of Nrf2 knockout on regulation of benzene-induced mouse hematotoxicity

(2018) Huiyao Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock

(2018) Chung Ho Leung et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 Signaling Elicits a Neuroprotective Role Against PFOS-mediated Oxidative Damage and Apoptosis

(2018) Pingping Sun et al.   NEUROCHEMICAL RESEARCH

Hormesis mediates dose-sensitive shifts in macrophage activation patterns

(2018) Edward J. Calabrese et al.   PHARMACOLOGICAL RESEARCH

Building Biological Shields via Hormesis

(2018) Edward J. Calabrese et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Estimating the range of the maximum hormetic stimulatory response

(2018) Edward J. Calabrese et al.   ENVIRONMENTAL RESEARCH

Upregulation of NRF2 through autophagy/ERK 1/2 ameliorates ionizing radiation induced cell death of human osteosarcoma U-2 OS

(2017) Ni Chen et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2

(2017) X. Zhao et al.   TOXICOLOGY LETTERS

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

(2017) Shikha Prasad et al.   Redox Biology

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

(2017) Chao Zhang et al.   Redox Biology

The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40 °C) against heat shock-induced apoptosis

(2016) Audrey Glory et al.   FREE RADICAL BIOLOGY AND MEDICINE

Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation

(2016) Yuguang Zhao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks

(2016) Edward J. Calabrese   PHARMACOLOGICAL RESEARCH

Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations

(2016) Edward J. Calabrese   PHARMACOLOGICAL RESEARCH

How sodium arsenite improve amyloid β-induced memory deficit?

(2016) Ehsan Nassireslami et al.   PHYSIOLOGY & BEHAVIOR

A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes

(2016) Gobinath Shanmugam et al.   Redox Biology

A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response

(2015) Tao Shen et al.   ANTIOXIDANTS & REDOX SIGNALING

Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity

(2015) Yi-Hsien Tsou et al.   EXPERIMENTAL NEUROLOGY

ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell

(2015) Ni Chen et al.   International Journal of Biological Sciences

Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells

(2015) Apei Jiang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway

(2015) Subhash Dwivedi et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective Effects of Tanshinone I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson’s Disease Through Upregulating Nrf2

(2015) Xu Jing et al.   NEUROCHEMICAL RESEARCH

Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept

(2014) Mireille M.J.P.E. Sthijns et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Iodoacetic Acid Activates Nrf2-Mediated Antioxidant Response in Vitro and in Vivo

(2014) Shu Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

(2014) Cliona Stack et al.   HUMAN MOLECULAR GENETICS

Neuroprotective Effects of Sulforaphane on Cholinergic Neurons in Mice with Alzheimer’s Disease-Like Lesions

(2014) Rui Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer

(2013) Bhupendra Singh et al.   BMC CANCER

Bisphenol A Activates the Nrf1/2-Antioxidant Response Element Pathway in HEK 293 Cells

(2013) Nikolai L. Chepelev et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Hormetic mechanisms

(2013) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood–brain barrier disruption and neurological deficits in stroke

(2013) Alessio Alfieri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Attenuation ofβ-Amyloid-Induced Oxidative Cell Death by Sulforaphane via Activation of NF-E2-Related Factor 2

(2013) Chan Lee et al.   Oxidative Medicine and Cellular Longevity

Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases

(2013) Andrea Tarozzi et al.   Oxidative Medicine and Cellular Longevity

Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model

(2012) Hyunjin Vincent Kim et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Does Nrf2 Contribute to p53-Mediated Control of Cell Survival and Death?

(2012) Weimin Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

(2012) Navneet Ammal Kaidery et al.   ANTIOXIDANTS & REDOX SIGNALING

Age-related cataracts: Homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection

(2012) Rajan Elanchezhian et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells

(2012) Han Xian Aw Yeang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

(2012) Tracy P. Williamson et al.   NEUROTOXICOLOGY

Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice: A Potential Mechanism to Prevent Diabetic Nephropathy

(2012) Xiao Xing et al.   Oxidative Medicine and Cellular Longevity

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation

(2012) S. B. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via antiapoptosis

(2012) Xuemei Wu et al.   Neuroscience Bulletin

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

“Lest we forget you — methylene blue …”

(2011) R. Heiner Schirmer et al.   NEUROBIOLOGY OF AGING

Potential roles of PI3K/Akt and Nrf2–Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation

(2011) Hongyi Qi et al.   NEUROPHARMACOLOGY

Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue

(2011) Julio C. Rojas et al.   PROGRESS IN NEUROBIOLOGY

The hormesis database: The occurrence of hormetic dose responses in the toxicological literature

(2011) Edward J. Calabrese et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Low-Dose Gamma-Ray Irradiation Induces Translocation of Nrf2 Into Nuclear in Mouse Macrophage RAW264.7 Cells

(2010) Mitsutoshi TSUKIMOTO et al.   JOURNAL OF RADIATION RESEARCH

Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes

(2010) David Vauzour et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity

(2010) Hirokazu Hara et al.   NEUROCHEMISTRY INTERNATIONAL

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells

(2009) Jun Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Phase I to II cross-induction of xenobiotic metabolizing enzymes: A feedforward control mechanism for potential hormetic responses

(2009) Qiang Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages

(2009) Courtney G. Woods et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HORMESIS: WHY IT IS IMPORTANT TO TOXICOLOGY AND TOXICOLOGISTS

(2008) Edward J. Calabrese   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection

(2008) C. Lai et al.   JOURNAL OF VIROLOGY

Methylmercury Toxicity and Nrf2-dependent Detoxification in Astrocytes

(2008) Ling Wang et al.   TOXICOLOGICAL SCIENCES

Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid

(2007) Jingbo Pi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY