Nrf2 Signaling Elicits a Neuroprotective Role Against PFOS-mediated Oxidative Damage and Apoptosis

Perfluorooctanesulfonate induces neuroinflammation through the secretion of TNF-α mediated by the JAK2/STAT3 pathway

(2018) Xiaoxu Chen et al.   NEUROTOXICOLOGY

Perfluorooctane sulfonate mediates secretion of IL-1β through PI3K/AKT NF-кB pathway in astrocytes

(2018) Xiaoxu Chen et al.   NEUROTOXICOLOGY AND TERATOLOGY

Acrylamide-induced oxidative stress and inflammatory response are alleviated by N -acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs

(2018) Xiaoqi Pan et al.   TOXICOLOGY LETTERS

PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons

(2018) Hanne Friis Berntsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of PFOS-mediated neurotoxicity in rat primary neurons and astrocytes cultured separately or in co-culture

(2017) Zhenwei Li et al.   TOXICOLOGY IN VITRO

Toxicity assessment of perfluorooctane sulfonate using acute and subchronic male C57BL/6J mouse models

(2016) Jiali Xing et al.   ENVIRONMENTAL POLLUTION

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics

(2015) Albena T. Dinkova-Kostova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

More signs of neurotoxicity of surfactants and flame retardants – Neonatal PFOS and PBDE 99 cause transcriptional alterations in cholinergic genes in the mouse CNS

(2015) Stefan Hallgren et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway

(2015) Hongguang Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sodium fluoride induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum stress pathway in Sertoli cells

(2015) Yang Yang et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Investigation of the Effects of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) on Apoptosis and Cell Cycle in a Zebrafish (Danio rerio) Liver Cell Line

(2015) Yuan Cui et al.   International Journal of Environmental Research and Public Health

Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review

(2014) Cathrine Carlsen Bach et al.   CRITICAL REVIEWS IN TOXICOLOGY

Comparison of waterborne and in ovo nanoinjection exposures to assess effects of PFOS on zebrafish embryos

(2014) Yabing Li et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Melatonin Antagonizes Mn-Induced Oxidative Injury Through the Activation of Keap1–Nrf2–ARE Signaling Pathway in the Striatum of Mice

(2014) Yu Deng et al.   NEUROTOXICITY RESEARCH

Chronic Exposure to Perfluorooctane Sulfonate Induces Behavior Defects and Neurotoxicity through Oxidative Damages, In Vivo and In Vitro

(2014) Na Chen et al.   PLoS One

Neurotoxicity of Perfluorooctane Sulfonate to Hippocampal Cells in Adult Mice

(2013) Yan Long et al.   PLoS One

Perfluorooctane sulfonate induces neuronal and oligodendrocytic differentiation in neural stem cells and alters the expression of PPARγ in vitro and in vivo

(2013) Wan Norhamidah Wan Ibrahim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL

(2012) Hui Tian et al.   CANCER LETTERS

Tissue distribution of perfluorinated compounds in farmed freshwater fish and human exposure by consumption

(2012) Yali Shi et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Perfluorooctane sulfonate induces apoptosis in lung cancer A549 cells through reactive oxygen species-mediated mitochondrion-dependent pathway

(2012) Zhenxing Mao et al.   JOURNAL OF APPLIED TOXICOLOGY

Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model

(2011) Anne E. Loccisano et al.   REPRODUCTIVE TOXICOLOGY

Perfluorooctane sulfonate increased hepatic expression of OAPT2 and MRP2 in rats

(2010) Wen-Guang Yu et al.   ARCHIVES OF TOXICOLOGY

Effects of subchronic perfluorooctane sulfonate exposure of rats on calcium-dependent signaling molecules in the brain tissue

(2010) Xiaohui Liu et al.   ARCHIVES OF TOXICOLOGY

Inflammation-like glial response in rat brain induced by prenatal PFOS exposure

(2010) Huai-cai Zeng et al.   NEUROTOXICOLOGY

Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway

(2009) G Liot et al.   CELL DEATH AND DIFFERENTIATION

The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

(2007) Ian M. Copple et al.   TOXICOLOGY