Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson’s disease and inflammatory pathways

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes

(2017) Shin-ichi Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biology of Microglia in the Developing Brain

(2017) Charanjit Kaur et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

Luteolin Inhibits Fibrillary β-Amyloid1–40-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-κB Signaling Pathways

(2017) Jun-Xia Zhang et al.   MOLECULES

Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy

(2017) Yanran Liang et al.   NEUROTOXICOLOGY

Ultrafine carbon particles promote rotenone-induced dopamine neuronal loss through activating microglial NADPH oxidase

(2017) Yinxi Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease

(2017) Hui-Fang Liu et al.   Scientific Reports

Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

(2017) Fei Gao et al.   Frontiers in Neurology

Role of dietary phenols in mitigating microglia-mediated neuroinflammation

(2016) Parakalan Rangarajan et al.   NEUROMOLECULAR MEDICINE

Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice

(2016) Michael D. Burton et al.   REJUVENATION RESEARCH

Unveiling the role of the pesticides paraquat and rotenone on α-synuclein fibrillation in vitro

(2015) Maurício Guilherme Valente Maturana et al.   NEUROTOXICOLOGY

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

(2015) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases

(2015) Carlos Fernández-Moriano et al.   Oxidative Medicine and Cellular Longevity

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6

(2015) I Tsilioni et al.   Translational Psychiatry

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

(2014) Qian Zhou et al.   TOXICOLOGICAL SCIENCES

Luteolin inhibits SH-SY5Y cell apoptosis through suppression of the nuclear transcription factor-κB, mitogen-activated protein kinase and protein kinase B pathways in lipopolysaccharide-stimulated cocultured BV2 cells

(2014) LIHONG ZHU et al.   Experimental and Therapeutic Medicine

Rotenone induces neuronal death by microglial phagocytosis of neurons

(2013) Julius V. Emmrich et al.   FEBS Journal

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

(2013) Jessica M. Crain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

(2013) Kuppusamy Tamilselvam et al.   Oxidative Medicine and Cellular Longevity

Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK Pathway

(2013) Feng Gao et al.   PLoS One

Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat

(2012) M. Sonia Angeline et al.   NEUROSCIENCE

Rotenone and Paraquat Linked to Parkinson’s Disease: Human Exposure Study Supports Years of Animal Studies

(2011) Angela Spivey   ENVIRONMENTAL HEALTH PERSPECTIVES

Luteolin Inhibits Microglial Inflammation and Improves Neuron Survival Against Inflammation

(2011) Li-Hong Zhu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammation: Modulation by flavonoids and mechanisms of action

(2011) Jeremy P.E. Spencer et al.   MOLECULAR ASPECTS OF MEDICINE

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life

(2011) Lir-Wan Fan et al.   NEUROBIOLOGY OF DISEASE

Luteolin reduces primary hippocampal neurons death induced by neuroinflammation

(2011) Li-Hong Zhu et al.   NEUROLOGICAL RESEARCH

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice

(2010) Saebyeol Jang et al.   JOURNAL OF NUTRITION

Parkin Suppresses c-Jun N-terminal kinase-induced cell death via transriptional regulation in Drosophila

(2010) Soojin Hwang et al.   MOLECULES AND CELLS

Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

(2009) A. K. Berger et al.   HUMAN MOLECULAR GENETICS

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

(2008) S. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA