Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

Active immunisation of human interferon   transgenic mice with a human interferon   Kinoid induces antibodies that neutralise interferon   in sera from patients with systemic lupus erythematosus

(2011) A. Mathian et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety profile and clinical activity of sifalimumab, a fully human anti-interferon   monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study

(2011) J. T. Merrill et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus

(2011) Alyssa M. Morimoto et al.   ARTHRITIS AND RHEUMATISM

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of B cell autoimmunity in SLE

(2011) Thomas Dörner et al.   ARTHRITIS RESEARCH & THERAPY

Kinoids: a family of immunogens for active anticytokine immunotherapy applied to autoimmune diseases and cancer

(2010) Bernard Bizzini et al.   Immunotherapy

Neutralization of interferon-α/β-inducible genes and downstream effect in a phase I trial of an anti-interferon-α monoclonal antibody in systemic lupus erythematosus

(2009) Yihong Yao et al.   ARTHRITIS AND RHEUMATISM

IFN  kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model

(2009) D. Zagury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA