IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with theIFN-λ3genotype and with nonresponsiveness to IFN-α therapies

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

(2013) Ole J Hamming et al.   EMBO JOURNAL

IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction

(2013) Stéphanie Bibert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Interferon-γ–Stimulated Genes, but Not USP18, Are Expressed in Livers of Patients With Acute Hepatitis C

(2012) Michael T. Dill et al.   GASTROENTEROLOGY

Interferon-lambda (IFN- ) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytes

(2012) H. Dickensheets et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells

(2012) A. Kohli et al.   JOURNAL OF VIRAL HEPATITIS

Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells

(2012) Angela Dolganiuc et al.   PLoS One

Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo

(2011) Zuzanna Makowska et al.   HEPATOLOGY

An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases

(2011) Marc G. Ghany et al.   HEPATOLOGY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C

(2010) Masao Honda et al.   GASTROENTEROLOGY

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

(2010) Andri Rauch et al.   GASTROENTEROLOGY

Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C

(2010) Michael T. Dill et al.   GASTROENTEROLOGY

IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C

(2010) Thomas J. Urban et al.   HEPATOLOGY

Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection

(2010) Andrew J. Muir et al.   HEPATOLOGY

Integrative genomic analyses on IL28RA, the common receptor of interferon-λ1, -λ2 and -λ3

(2010) Wei   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-Claudin-1 associations

(2009) Sophie E. Krieger et al.   HEPATOLOGY

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

(2009) M. Sarasin-Filipowicz et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Interferon signaling and treatment outcome in chronic hepatitis C

(2008) M. Sarasin-Filipowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens