Contribution of type III interferons to antiviral immunity: location, location, location

IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

(2016) Sophia Davidson et al.   EMBO Molecular Medicine

Host – hepatitis C viral interactions: The role of genetics

(2016) Markus H. Heim et al.   JOURNAL OF HEPATOLOGY

Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway

(2016) Aoife Kelly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Comparative Functional Analysis of 12 Mammalian IFN-λ4 Orthologs

(2016) Ashley Paquin et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Peculiar Characteristics of Fish Type I Interferons

(2016) Pierre Boudinot et al.   Viruses-Basel

Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections

(2016) Jian-Da Lin et al.   PLoS Pathogens

Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity

(2016) Yongming Sang et al.   Scientific Reports

ID: 52

(2015) Jonas Klinkhammer et al.   CYTOKINE

Cut, copy, move, delete: The study of human interferon genes reveal multiple mechanisms underlying their evolution in amniotes

(2015) Christopher D. Krause et al.   CYTOKINE

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

(2015) Katrina Blazek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

(2015) Isabella Rauch et al.   MOLECULAR AND CELLULAR BIOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

NK cells require IL-28R for optimal in vivo activity

(2015) Fernando Souza-Fonseca-Guimaraes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

(2015) Helen M. Lazear et al.   Science Translational Medicine

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

(2015) Mahima Swamy et al.   Nature Communications

Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

(2015) Tanel Mahlakõiv et al.   PLoS Pathogens

Impairment of Type I but Not Type III IFN Signaling by Hepatitis C Virus Infection Influences Antiviral Responses in Primary Human Hepatocytes

(2015) Jacques Friborg et al.   PLoS One

IFN-λ-mediated IL-12 production in macrophages induces IFN-γ production in human NK cells

(2014) Rik A. de Groen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IFNL cytokines do not modulate human or murine NK cell functions

(2014) Maria H. Morrison et al.   HUMAN IMMUNOLOGY

Transcriptional Regulation ofIFN-λ Genes in Hepatitis C Virus-infected Hepatocytes via IRF-3·IRF-7·NF-κB Complex

(2014) Hai-Chon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with theIFN-λ3genotype and with nonresponsiveness to IFN-α therapies

(2014) Francois H.T. Duong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection

(2014) Andrew J. Muir et al.   JOURNAL OF HEPATOLOGY

An Important Role for Type III Interferon (IFN- /IL-28) in TLR-Induced Antiviral Activity

(2014) N. Ank et al.   JOURNAL OF IMMUNOLOGY

Differentiated Human Alveolar Type II Cells Secrete Antiviral IL-29 (IFN- 1) in Response to Influenza A Infection

(2014) J. Wang et al.   JOURNAL OF IMMUNOLOGY

IFN-  Exerts Opposing Effects on T Cell Responses Depending on the Chronicity of the Virus Infection

(2014) I. Misumi et al.   JOURNAL OF IMMUNOLOGY

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

(2014) Charlotte Odendall et al.   NATURE IMMUNOLOGY

Commensal microbes and interferon-  determine persistence of enteric murine norovirus infection

(2014) M. T. Baldridge et al.   SCIENCE

Interferon-  cures persistent murine norovirus infection in the absence of adaptive immunity

(2014) T. J. Nice et al.   SCIENCE

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

(2014) Ewa Terczyńska-Dyla et al.   Nature Communications

HCV Infection Selectively Impairs Type I but Not Type III IFN Signaling

(2013) Partha K. Chandra et al.   AMERICAN JOURNAL OF PATHOLOGY

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

(2013) Ole J Hamming et al.   EMBO JOURNAL

Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10

(2013) Christoph Burkart et al.   EMBO Molecular Medicine

Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus

(2013) Nikolaus Jilg et al.   HEPATOLOGY

Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression

(2013) Christopher R. Bolen et al.   HEPATOLOGY

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection

(2013) Shin-ichiro Nakagawa et al.   PLoS One

Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue Samples

(2013) Ahmad Amanzada et al.   PLoS One

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

(2013) Stefania Crotta et al.   PLoS Pathogens

HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons

(2012) Emmanuel Thomas et al.   GASTROENTEROLOGY

Human Type 2 Myeloid Dendritic Cells Produce Interferon-λ and Amplify Interferon-α in Response to Hepatitis C Virus Infection

(2012) Shuye Zhang et al.   GASTROENTEROLOGY

Human blood dendritic cell antigen 3 (BDCA3)+dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus

(2012) Sachiyo Yoshio et al.   HEPATOLOGY

Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread

(2012) T. Mahlakoiv et al.   JOURNAL OF GENERAL VIROLOGY

Type III IFNs Are Produced by and Stimulate Human Plasmacytoid Dendritic Cells

(2012) Z. Yin et al.   JOURNAL OF IMMUNOLOGY

Interferon-lambda (IFN- ) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytes

(2012) H. Dickensheets et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta

(2012) Hélène Bierne et al.   PLoS One

IFN-λs

(2011) Sergei V Kotenko   CURRENT OPINION IN IMMUNOLOGY

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

(2011) Ourania Koltsida et al.   EMBO Molecular Medicine

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures

(2011) Svetlana Marukian et al.   HEPATOLOGY

Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN

(2011) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

IFN-  determines the intestinal epithelial antiviral host defense

(2011) J. Pott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Bacterial Protein Targets the BAHD1 Chromatin Complex to Stimulate Type III Interferon Response

(2011) A. Lebreton et al.   SCIENCE

Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells

(2011) Tamaki Okabayashi et al.   VIRUS RESEARCH

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

IL-4 enhances IFN- 1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra

(2010) N. J. Megjugorac et al.   BLOOD

Antitumor activity of Type I and Type III interferons in BNL hepatoma model

(2010) Walid Abushahba et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Mouse CD8α+DCs and human BDCA3+DCs are major producers of IFN-λ in response to poly IC

(2010) Henning Lauterbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intron-Containing Type I and Type III IFN Coexist in Amphibians: Refuting the Concept That a Retroposition Event Gave Rise to Type I IFNs

(2010) Z. Qi et al.   JOURNAL OF IMMUNOLOGY

Interferon-Lambda: A New Addition to an Old Family

(2010) Raymond P. Donnelly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Mechanisms of Type III Interferon Expression

(2010) Marie B. Iversen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Expression of Type III Interferon (IFN) in the Vaginal Mucosa Is Mediated Primarily by Dendritic Cells and Displays Stronger Dependence on NF- B than Type I IFNs

(2010) M. B. Iversen et al.   JOURNAL OF VIROLOGY

Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo

(2010) N. A. Jewell et al.   JOURNAL OF VIROLOGY

Temporal and Spatial Resolution of Type I and III Interferon Responses In Vivo

(2010) J. E. Pulverer et al.   JOURNAL OF VIROLOGY

Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells

(2009) M. R. Khaitov et al.   ALLERGY

Despite IFN-λ receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines

(2009) K Witte et al.   GENES AND IMMUNITY

The Two Groups of Zebrafish Virus-Induced Interferons Signal via Distinct Receptors with Specific and Shared Chains

(2009) D. Aggad et al.   JOURNAL OF IMMUNOLOGY

Modulation of human plasmacytoid DC function by IFN-λ1 (IL-29)

(2009) Nicholas J. Megjugorac et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of transposable elements in the regulation of IFN-λ1 gene expression

(2009) Scott J. P. Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human interferon-λ3 is a potent member of the type III interferon family

(2008) C Dellgren et al.   GENES AND IMMUNITY

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens