Dissolving the Complex Role Aggregation Plays in Neurodegenerative Disease

Autophagy participates in, well, just about everything

(2020) Daniel J. Klionsky   CELL DEATH AND DIFFERENTIATION

Selective autophagy degrades nuclear pore complexes

(2020) Chia-Wei Lee et al.   NATURE CELL BIOLOGY

Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice

(2020) Su Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

(2020) Insup Choi et al.   Nature Communications

The role of glia in protein aggregation

(2020) Qingyun Li et al.   NEUROBIOLOGY OF DISEASE

Nucleophagy: from homeostasis to disease

(2019) Margarita-Elena Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Tauopathy: A common mechanism for neurodegeneration and Brain Aging

(2019) Pampa Saha et al.   MECHANISMS OF AGEING AND DEVELOPMENT

NIPSNAP1 and NIPSNAP2 act as “eat me” signals to allow sustained recruitment of autophagy receptors during mitophagy

(2019) Yakubu Princely Abudu et al.   Autophagy

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

(2019) Naomi P. Visanji et al.   Translational Neurodegeneration

Cryo-EM of amyloid fibrils and cellular aggregates

(2019) Anthony WP Fitzpatrick et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Huntington’s Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy

(2019) Leora M. Fox et al.   NEURON

Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

(2018) Shahzad S. Khan et al.   ACTA NEUROPATHOLOGICA

Polyglutamine expansion diseases: More than simple repeats

(2018) Alexandra Silva et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

(2018) Matheus B. Victor et al.   NATURE NEUROSCIENCE

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

(2018) Friederike Zunke et al.   NEURON

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

(2018) Maneka Chitiprolu et al.   Nature Communications

The Insoluble Protein Deposit (IPOD) in Yeast

(2018) Stephanie Rothe et al.   Frontiers in Molecular Neuroscience

Characterization of the Partially Folded States of TDP-43 RRM2 and Their Significance to ALS Pathogenesis

(2018) Davide Tavella et al.   BIOPHYSICAL JOURNAL

Repeat associated non-ATG (RAN) translation

(2018) John Douglas Cleary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-phagy at a glance

(2018) Paolo Grumati et al.   JOURNAL OF CELL SCIENCE

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

(2018) Sarah C. Hopp et al.   Journal of Neuroinflammation

A53T mutant alpha-synuclein induces tau dependent postsynaptic impairment independent of neurodegenerative changes

(2018) Peter J. Teravskis et al.   JOURNAL OF NEUROSCIENCE

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

A role for autophagy in Huntington's disease

(2018) Katherine R. Croce et al.   NEUROBIOLOGY OF DISEASE

Molecular Pathogenesis of the Tauopathies

(2018) Jürgen Götz et al.   Annual Review of Pathology-Mechanisms of Disease

Oligodendroglial A‐synucleinopathy driven neuroinflammation in multiple system atrophy

(2018) Alana Hoffmann et al.   BRAIN PATHOLOGY

Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos

(2018) Takuya Noguchi et al.   Cell Death & Disease

Tau-based therapies in neurodegeneration: opportunities and challenges

(2017) Chuanzhou Li et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of the co-deposition of multiple pathological proteins in neurodegenerative diseases

(2017) Takashi Nonaka et al.   NEUROPATHOLOGY

Autophagy Receptors and Neurodegenerative Diseases

(2017) Zhiqiang Deng et al.   TRENDS IN CELL BIOLOGY

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Is Tau Aggregation Toxic or Protective: A Sensible Question in the Absence of Sensitive Methods?

(2017) Jürgen Götz et al.   JOURNAL OF ALZHEIMERS DISEASE

TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing

(2016) Kirsty E. McAleese et al.   BRAIN PATHOLOGY

Distinguishing aggregate formation and aggregate clearance using cell-based assays

(2016) Evelien Eenjes et al.   JOURNAL OF CELL SCIENCE

Review: The spectrum of clinical features seen with alpha synuclein pathology

(2016) R. A. Barker et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain

(2016) Joanna M Dragich et al.   eLife

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

(2015) Benjamin Ettle et al.   MOLECULAR NEUROBIOLOGY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

RAN Translation in Huntington Disease

(2015) Monica Bañez-Coronel et al.   NEURON

Autophagy and Its Normal and Pathogenic States in the Brain

(2014) Ai Yamamoto et al.   Annual Review of Neuroscience

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

(2014) Masaru Kurosawa et al.   HUMAN MOLECULAR GENETICS

Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2014) Huihui Han et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

(2014) Sami J Barmada et al.   Nature Chemical Biology

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology

(2014) Lori A. Orosco et al.   Nature Communications

RNA toxicity in human disease and animal models: From the uncovering of a new mechanism to the development of promising therapies

(2013) Géraldine Sicot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aggregation formation in the polyglutamine diseases: Protection at a cost?

(2013) Tiffany W. Todd et al.   MOLECULES AND CELLS

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome

(2013) Peter K. Todd et al.   NEURON

The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

(2013) K. Mori et al.   SCIENCE

Are Tau Aggregates Toxic or Protective in Tauopathies?

(2013) Catherine M. Cowan et al.   Frontiers in Neurology

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

 -Syn Suppression Reverses Synaptic and Memory Defects in a Mouse Model of Dementia with Lewy Bodies

(2011) Y. Lim et al.   JOURNAL OF NEUROSCIENCE

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

(2011) Todd J. Cohen et al.   TRENDS IN MOLECULAR MEDICINE

Cellular Strategies of Protein Quality Control

(2011) B. Chen et al.   Cold Spring Harbor Perspectives in Biology

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

Non-ATG-initiated translation directed by microsatellite expansions

(2010) T. Zu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

TDP-43 in neurodegenerative disorders

(2008) Casey Cook et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Animal Models of Polyglutamine Diseases and Therapeutic Approaches

(2008) J. Lawrence Marsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE