Distinguishing aggregate formation and aggregate clearance using cell-based assays

Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 mice

(2014) Akiko Kuma et al.   Autophagy

Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates

(2014) E-J Bae et al.   CELL DEATH AND DIFFERENTIATION

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Ubiquitin–proteasome system involvement in Huntington’s disease

(2014) Zaira Ortega et al.   Frontiers in Molecular Neuroscience

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies

(2013) Sabine Schipper-Krom et al.   FEBS LETTERS

Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes

(2013) Katrin Juenemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy

(2012) Saori Odagiri et al.   ACTA NEUROPATHOLOGICA

Receptor protein complexes are in control of autophagy

(2012) Dalibor Mijaljica et al.   Autophagy

Modulating macroautophagy: a neuronal perspective

(2012) Christopher W Johnson et al.   Future Medicinal Chemistry

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

(2011) M Laura Cremona et al.   NATURE NEUROSCIENCE

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

(2010) Weiliang Fan et al.   Autophagy

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones

(2010) Michel J. Vos et al.   HUMAN MOLECULAR GENETICS

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin–proteasome pathways

(2010) Huali Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration

(2010) Ai Yamamoto et al.   NEUROBIOLOGY OF DISEASE

Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation

(2010) M. Stiess et al.   SCIENCE

HSPB7 is a SC35 speckle resident small heat shock protein

(2009) Michel J. Vos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System

(2009) Atsushi Iwata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43

(2009) Makoto Urushitani et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity

(2008) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY