Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors

Current status and future prospects of p38α/MAPK14 kinase and its inhibitors

(2021) Moustafa M. Madkour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases

(2021) Zhouling Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in c-Jun N-terminal Kinase (JNK) Inhibitors

(2020) Gang Li et al.   CURRENT MEDICINAL CHEMISTRY

ASK1 inhibition: a therapeutic strategy with multi-system benefits

(2020) Jacqueline M. Ogier et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Levo-corydalmine attenuates microglia activation and neuropathic pain by suppressing ASK1-p38 MAPK/NF-κB signaling pathways in rat spinal cord

(2020) Wen-Ling Dai et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Src-family protein tyrosine kinases: A promising target for treating chronic pain

(2020) Meng-Meng Ge et al.   BIOMEDICINE & PHARMACOTHERAPY

p38 mitogen-activated protein kinase and pain

(2020) Lijia Mai et al.   LIFE SCIENCES

Lorecivivint, a Novel Intra‐articular CLK/DYRK1A Inhibitor and Wnt Pathway Modulator for Treatment of Knee Osteoarthritis: A Phase 2 Randomized Trial

(2020) Yusuf Yazici et al.   Arthritis & Rheumatology

The role of cyclin dependent kinase 5 (Cdk5) in neuropathic pain

(2020) Kimberly Gomez et al.   PAIN

Functions of p38 MAP Kinases in the Central Nervous System

(2020) Prita R. Asih et al.   Frontiers in Molecular Neuroscience

The role of glycogen synthase kinase 3 beta in multiple sclerosis

(2020) Tayebeh Noori et al.   BIOMEDICINE & PHARMACOTHERAPY

Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain

(2020) Muhammad Saad Yousuf et al.   PHARMACOLOGICAL REVIEWS

Astrocyte activation in the periaqueductal gray promotes descending facilitation to cancer-induced bone pain through the JNK MAPK signaling pathway

(2019) Hua-dong Ni et al.   Molecular Pain

Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain

(2019) Danli Zhou et al.   Journal of Neuroinflammation

The discovery of novel 3-aryl-indazole derivatives as peripherally restricted pan-Trk inhibitors for the treatment of pain

(2019) Hiromitsu Shirahashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

(2019) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia

(2019) Alexia Visseq et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of the endogenous neurotransmitters associated with neuropathic pain and in the opioid crisis: The innate pain-relieving system

(2019) E.Gy Bán et al.   BRAIN RESEARCH BULLETIN

Spinal Protein Kinase Mζ Regulates α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Trafficking and Dendritic Spine Plasticity via Kalirin-7 in the Pathogenesis of Remifentanil-induced Postincisional Hyperalgesia in Rats

(2018) Linlin Zhang et al.   ANESTHESIOLOGY

Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

(2018) Russell A. Judge et al.   CHEMBIOCHEM

Structural optimization and structure-activity relationship studies of N -phenyl-7,8-dihydro-6 H -pyrimido[5,4-b][1,4]oxazin-4-amine derivatives as a new class of inhibitors of RET and its drug resistance mutants

(2018) Jiao Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46

(2018) Liying Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

(2018) Sharan K. Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

From Cancer to Pain Target by Automated Selectivity Inversion of a Clinical Candidate

(2018) Samo Turk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent, Selective and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

(2018) Sharan K Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Mechanism of Hyperalgesia and Anxiety Induced by Remifentanil: Phosphorylation of GluR1 Receptors in the Anterior Cingulate Cortex

(2018) Jie Zeng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Synergistic activation of ERK1/2 between A-fiber neurons and glial cells in the DRG contributes to pain hypersensitivity after tissue injury

(2018) Shunsuke Yamakita et al.   Molecular Pain

Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway

(2018) Fausto Salaffi et al.   Pain Research & Management

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

(2018) Hilary Schenck Eidam et al.   ACS Medicinal Chemistry Letters

Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

(2018) Cyril Rivat et al.   Nature Communications

Influence of Phosphatidylinositol-3-Kinase/Protein Kinase B-Mammalian Target of Rapamycin Signaling Pathway on the Neuropathic Pain Complicated by Nucleoside Reverse Transcriptase Inhibitors for the Treatment of HIV Infection

(2018) Hao Cheng et al.   CHINESE MEDICAL JOURNAL

Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition

(2018) Tyler S. Beyett et al.   MOLECULAR PHARMACOLOGY

Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity

(2018) John P. Russell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice

(2018) Christine V. Möser et al.   NEUROPHARMACOLOGY

Identification of a novel 5-amino-3-(5-cyclopropylisoxazol-3-yl)-1-isopropyl-1H-pyrazole-4-carboxamide as a specific RET kinase inhibitor

(2017) Hojong Yoon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation and Characterization of Trk Kinase Inhibitors for the Treatment of Pain: Reliable Binding Affinity Predictions from Theory and Computation

(2017) Shunzhou Wan et al.   Journal of Chemical Information and Modeling

A novel inhibitor of active protein kinase G attenuates chronic inflammatory and osteoarthritic pain

(2017) Ying-Ju Sung et al.   PAIN

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

(2017) Marion Lanier et al.   ACS Medicinal Chemistry Letters

Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain

(2017) Myeounghoon Cha et al.   Scientific Reports

The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain

(2017) Camilla Kristine Appel et al.   Scientific Reports

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of medullary dorsal horn γ isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia

(2016) Nathalie Pham-Dang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

(2016) Laurent Meijer et al.   Journal of Innate Immunity

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain

(2016) Sarah E. Skerratt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blockade of the spinal BDNF-activated JNK pathway prevents the development of antiretroviral-induced neuropathic pain

(2016) Maria Domenica Sanna et al.   NEUROPHARMACOLOGY

Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain

(2016) Masahiro Ohsawa et al.   NEUROSCIENCE

Cell cycle inhibition limits development and maintenance of neuropathic pain following spinal cord injury

(2016) Junfang Wu et al.   PAIN

Structural characterization of nonactive site, TrkA-selective kinase inhibitors

(2016) Hua-Poo Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Cabozantinib on Pain and Narcotic Use in Patients with Castration-resistant Prostate Cancer: Results from a Phase 2 Nonrandomized Expansion Cohort

(2015) Ethan Basch et al.   EUROPEAN UROLOGY

Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications

(2015) Priyanka Purkayastha et al.   Molecular Informatics

Intrathecal injection of KN93 attenuates paradoxical remifentanil-induced postoperative hyperalgesia by inhibiting spinal CaMKII phosphorylation in rats

(2015) Ming Jiang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase

(2015) Marialuisa Moccia et al.   PLoS One

Effect of Antidepressants and Psychological Therapies, Including Hypnotherapy, in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis

(2014) Alexander C Ford et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia

(2014) Hanneke L. D. M. Willemen et al.   BIOCHEMICAL JOURNAL

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channelsin vitroand painin vivo

(2014) M S Grace et al.   BRITISH JOURNAL OF PHARMACOLOGY

p38 MAPK: A Potential Target of Chronic Pain

(2014) X. Lin et al.   CURRENT MEDICINAL CHEMISTRY

Spinal protein kinase Mζ contributes to the maintenance of peripheral inflammation-primed persistent nociceptive sensitization after plantar incision

(2014) K. An et al.   EUROPEAN JOURNAL OF PAIN

Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

(2014) Shawn J. Stachel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alleviation of Behavioral Hypersensitivity in Mouse Models of Inflammatory Pain with Two Structurally Different Casein Kinase 1 (CK1) Inhibitors

(2014) Takashi Kurihara et al.   Molecular Pain

The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care

(2013) Harald Breivik et al.   BMC PUBLIC HEALTH

Mechanism-driven phase I translational study of trifluoperazine in adults with sickle cell disease

(2013) Robert E. Molokie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Inhibition of Glycogen Synthase Kinase-3β Prevents Remifentanil-Induced Hyperalgesia via Regulating the Expression and Function of Spinal N-Methyl-D-Aspartate Receptors In Vivo and Vitro

(2013) Yize Li et al.   PLoS One

Trigeminal Nerve Injury ErbB3/ErbB2 Promotes Mechanical Hypersensitivity

(2012) Fei Ma et al.   ANESTHESIOLOGY

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: Evidence for the mechanisms of action

(2012) L. Mazzardo-Martins et al.   NEUROSCIENCE

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties

(2011) Fabrice Pierre et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Novel Inhibitors of Tropomyosin-Related Kinase A through the Structure-Based Virtual Screening with Homology-Modeled Protein Structure

(2011) Hwangseo Park et al.   Journal of Chemical Information and Modeling

Identification of 3H-Naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of Apoptosis Signal-Regulating Kinase 1 (ASK1)

(2011) Galyna P. Volynets et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth

(2011) F. M. Yakes et al.   MOLECULAR CANCER THERAPEUTICS

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor

(2011) Solveigh C Koeberle et al.   Nature Chemical Biology

Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice

(2011) Ilona Obara et al.   PAIN

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

(2010) Debra M Meyer et al.   Journal of Inflammation-London

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

(2010) Qingsong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mammalian Target of Rapamycin Signaling in the Spinal Cord Is Required for Neuronal Plasticity and Behavioral Hypersensitivity Associated With Neuropathy in the Rat

(2010) Curtis O. Asante et al.   JOURNAL OF PAIN

Characterization of Fasudil in Preclinical Models of Pain

(2010) Janel M. Boyce-Rustay et al.   JOURNAL OF PAIN

The Antinociceptive Effects of AR-A014418, a Selective Inhibitor of Glycogen Synthase Kinase-3 Beta, in Mice

(2010) Daniel F. Martins et al.   JOURNAL OF PAIN

Administration of a Tropomyosin Receptor Kinase Inhibitor Attenuates Sarcoma-Induced Nerve Sprouting, Neuroma Formation and Bone Cancer Pain

(2010) Joseph R Ghilardi et al.   Molecular Pain

Cyclotraxin-B, the First Highly Potent and Selective TrkB Inhibitor, Has Anxiolytic Properties in Mice

(2010) Maxime Cazorla et al.   PLoS One

Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKM  in the Anterior Cingulate Cortex

(2010) X.-Y. Li et al.   SCIENCE

Tricyclic antidepressants and headaches: systematic review and meta-analysis

(2010) J. L. Jackson et al.   BMJ-British Medical Journal

Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial

(2009) J H Coombs et al.   ANNALS OF THE RHEUMATIC DISEASES

Acute Inhibition of Ca2+/Calmodulin-Dependent Protein Kinase II Reverses Experimental Neuropathic Pain in Mice

(2009) Y. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts

(2009) K. F. Byth et al.   MOLECULAR CANCER THERAPEUTICS

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis

(2008) B. Shor et al.   CANCER RESEARCH

Reversal of Chronic Inflammatory Pain by Acute Inhibition of Ca2+/Calmodulin-Dependent Protein Kinase II

(2008) F. Luo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Rationally designed peptide regulators of protein kinase C

(2008) Eric N. Churchill et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM