Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46

How Good Intentions Contributed to Bad Outcomes: The Opioid Crisis

(2018) Teresa A. Rummans et al.   MAYO CLINIC PROCEEDINGS

Calculating the Real Costs of the Opioid Crisis

(2018) Sheryl A. Ryan   PEDIATRICS

The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43

(2017) Hema Kalyanaraman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NSAIDs and cardiovascular risk

(2017) Fabio Marsico et al.   Journal of Cardiovascular Medicine

Cyclic GMP-dependent protein kinase-I localized in nociceptors modulates nociceptive cortical neuronal activity and pain hypersensitivity

(2017) Vijayan Gangadharan et al.   Molecular Pain

A novel inhibitor of active protein kinase G attenuates chronic inflammatory and osteoarthritic pain

(2017) Ying-Ju Sung et al.   PAIN

Crystal structure of cGMP-dependent protein kinase Iβ cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation

(2016) James C. Campbell et al.   FEBS LETTERS

Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation

(2016) Jeong Joo Kim et al.   STRUCTURE

Structures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability

(2015) Liying Qin et al.   BIOCHEMISTRY

Tyrosine Kinase Inhibitors and Diabetes: A Novel Treatment Paradigm?

(2015) Athanasios Fountas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Prevalence and Characteristics of Fibromyalgia in the 2012 National Health Interview Survey

(2015) Brian Walitt et al.   PLoS One

Cutaneous expression of calcium/calmodulin-dependent protein kinase II in rats with type 1 and type 2 diabetes

(2014) Matija Boric et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity

(2012) Ceng Luo et al.   PLOS BIOLOGY

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication

(2011) Brent W. Osborne et al.   STRUCTURE

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

(2009) Jürgen Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY

cGMP-binding Prepares PKG for Substrate Binding by Disclosing the C-terminal Domain

(2007) Vera Alverdi et al.   JOURNAL OF MOLECULAR BIOLOGY