Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain

Induction of suppressor of cytokine signaling 3 via HSF-1-HSP70-TLR4 axis attenuates neuroinflammation and ameliorates postoperative pain

(2018) Yi-Xin Fan et al.   BRAIN BEHAVIOR AND IMMUNITY

GPCR kinase 2–interacting protein-1 protects against ischemia-reperfusion injury of the spinal cord by modulating ASK1/JNK/p38 signaling

(2018) Jian Chen et al.   FASEB JOURNAL

Cell Type-Specific Mechanisms in the Pathogenesis of Ischemic Stroke: The Role of Apoptosis Signal-Regulating Kinase 1

(2018) So Yeong Cheon et al.   Oxidative Medicine and Cellular Longevity

Sustained MAPK/ERK Activation in Adult Schwann Cells Impairs Nerve Repair

(2017) Ilaria Cervellini et al.   JOURNAL OF NEUROSCIENCE

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Computational protein–ligand docking and virtual drug screening with the AutoDock suite

(2016) Stefano Forli et al.   Nature Protocols

N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases

(2016) Jiajie Li et al.   PAIN

Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway

(2015) Qing-Qing Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcitonin Gene-Related Peptide (CGRP): A New Target for Migraine

(2015) Andrew F. Russo   Annual Review of Pharmacology and Toxicology

Inhibition of thioredoxin-1 with siRNA exacerbates apoptosis by activating the ASK1-JNK/p38 pathway in brain of a stroke model rats

(2015) Xiaoying Wu et al.   BRAIN RESEARCH

Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

(2015) Shreyasi Palit et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of JNK pathway in spinal astrocytes contributes to acute ultra–low-dose morphine thermal hyperalgesia

(2015) Maria Domenica Sanna et al.   PAIN

Selective suppression of microglial activation by paeoniflorin attenuates morphine tolerance

(2014) C. Jiang et al.   EUROPEAN JOURNAL OF PAIN

Apoptosis signal-regulating kinase 1 as a therapeutic target

(2014) Yosuke Kawarazaki et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain

(2014) Emiko Tatsumi et al.   GLIA

Biophysical and Structural Characterization of the Thioredoxin-binding Domain of Protein Kinase ASK1 and Its Interaction with Reduced Thioredoxin

(2014) Dalibor Kosek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spinal sample showing p-JNK and P38 associated with the pain signaling transduction of glial cell in neuropathic pain

(2014) J Cao et al.   SPINAL CORD

Total glucosides of paeony prevents juxta-articular bone loss in experimental arthritis

(2013) Chen Chao Wei et al.   BMC Complementary and Alternative Medicine

Dynamic genotype-selective “phenotypic switching” of CGRP expression contributes to differential neuropathic pain phenotype

(2013) Adi Nitzan-Luques et al.   EXPERIMENTAL NEUROLOGY

Central Sensitization and MAPKs Are Involved in Occlusal Interference-Induced Facial Pain in Rats

(2013) Ye Cao et al.   JOURNAL OF PAIN

Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design

(2013) Onkar Singh et al.   PROTEIN SCIENCE

A Central Role for the ERK-Signaling Pathway in Controlling Schwann Cell Plasticity and Peripheral Nerve Regeneration In Vivo

(2012) Ilaria Napoli et al.   NEURON

Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT2A receptor antagonist ketanserin in rats

(2012) Dongmei Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

TLR4 Activity Is Required in the Resolution of Pulmonary Inflammation and Fibrosis after Acute and Chronic Lung Injury

(2011) Hong-Zhen Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: Multi-electrode array recordings

(2011) Ming-Gang Liu et al.   BRAIN RESEARCH

Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain

(2011) Xiao-Peng Mei et al.   Journal of Neuroinflammation

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

(2011) Mitchell S Stark et al.   NATURE GENETICS

PPARγ agonist pioglitazone inhibits microglia inflammation by blocking p38 mitogen-activated protein kinase signaling pathways

(2010) Huoyan Ji et al.   INFLAMMATION RESEARCH

Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways

(2010) Der-Sheng Han et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Vitamin D3 Upregulated Protein 1 Suppresses TNF- -Induced NF- B Activation in Hepatocarcinogenesis

(2010) H.-J. Kwon et al.   JOURNAL OF IMMUNOLOGY

Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

(2010) Ralf Baron et al.   LANCET NEUROLOGY

Facilitation of Synaptic Transmission and Pain Responses by CGRP in the Amygdala of Normal Rats

(2010) Jeong S Han et al.   Molecular Pain

Nociceptor sensitization in pain pathogenesis

(2010) Michael S Gold et al.   NATURE MEDICINE

Central mechanisms of pathological pain

(2010) Rohini Kuner   NATURE MEDICINE

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY