The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease

Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERα via intermolecular interactions

(2021) Sudhir Kumar et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity

(2021) Xiao Cheng et al.   Redox Biology

Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions

(2020) Xiaojiaoyang Li et al.   Cells

Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma

(2020) Haider M. Hassan et al.   Cell Reports

LncRNA-H19 induces hepatic stellate cell activation via upregulating alcohol dehydrogenase III-mediated retinoic acid signals

(2020) Zhi-Min Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Non-Coding RNAs as Potential Novel Biomarkers for Early Diagnosis of Hepatic Insulin Resistance

(2020) Ariadna Pielok et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay

(2020) Sarah E. Fritz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The small heterodimer partner inhibits activation of hepatic stellate cells via autophagy

(2020) Wei Ma et al.   Advances in Clinical and Experimental Medicine

Gene regulation by long non-coding RNAs and its biological functions

(2020) Luisa Statello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

(2020) Young-Chae Kim et al.   Nature Communications

Long noncoding RNA MEG3 blocks telomerase activity in human liver cancer stem cells epigenetically

(2020) Xiaoxue Jiang et al.   Stem Cell Research & Therapy

H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

(2019) Li Zhang et al.   Cell Death & Disease

MEG3: an Oncogenic Long Non-coding RNA in Different Cancers

(2019) Arwa Al-Rugeebah et al.   PATHOLOGY & ONCOLOGY RESEARCH

Long non‐coding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia

(2019) Yongtao Xiao et al.   HEPATOLOGY

Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis

(2019) Runping Liu et al.   HEPATOLOGY

LncRNA MEG3 functions as a ceRNA in regulating hepatic lipogenesis by competitively binding to miR-21 with LRP6

(2019) Peng Huang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus

(2019) Jae-Hoon Kim et al.   Cell Reports

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

(2019) Shengyi Sun et al.   GENES & DEVELOPMENT

Crosstalk Between Long Non-coding RNAs, Micro-RNAs and mRNAs: Deciphering Molecular Mechanisms of Master Regulators in Cancer

(2019) Eduardo López-Urrutia et al.   Frontiers in Oncology

MicroRNA‐210 promotes bile acid‐induced cholestatic liver injury by targeting mixed‐lineage leukemia‐4 methyltransferase in mice

(2019) Young‐Chae Kim et al.   HEPATOLOGY

Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels

(2019) Xiaopei Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long non‐coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes

(2019) Hao Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

LncRNA H19/microRNA-675/PPARα axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling

(2019) Yiqing Liu et al.   MOLECULAR IMMUNOLOGY

Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway

(2018) Ji Ye Lim et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner

(2018) Yong-Hoon Kim et al.   ARCHIVES OF TOXICOLOGY

Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans

(2018) Xiaojiaoyang Li et al.   HEPATOLOGY

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

(2018) Adrian P. Mansini et al.   HEPATOLOGY

Long noncoding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis

(2018) Chune Liu et al.   HEPATOLOGY

Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice

(2018) Xiaoying Liu et al.   HEPATOLOGY

Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

(2018) An Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation

(2018) Haoming Zhou et al.   JOURNAL OF HEPATOLOGY

DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis

(2018) Jing-Jing Yang et al.   TOXICOLOGY LETTERS

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

(2018) Young-Chae Kim et al.   Nature Communications

The Long Non-coding RNA MEG3/miR-let-7c-5p Axis Regulates Ethanol-Induced Hepatic Steatosis and Apoptosis by Targeting NLRC5

(2018) Qin Wang et al.   Frontiers in Pharmacology

Local synthesis of immunosuppressive glucocorticoids in the intestinal epithelium regulates anti-viral immune responses

(2018) Juan Huang et al.   CELLULAR IMMUNOLOGY

Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation

(2018) Jung-Ran Noh et al.   Scientific Reports

Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19

(2018) Yinpeng Jin et al.   EBioMedicine

DNA methylation controls metastasis-suppressive 14q32-encoded miRNAs

(2018) Go Oshima et al.   CANCER RESEARCH

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption

(2018) Young-Chae Kim et al.   GASTROENTEROLOGY

LncRNA-H19 activates CDC42/PAK1 pathway to promote cell proliferation, migration and invasion by targeting miR-15b in hepatocellular carcinoma

(2018) Yong Zhou et al.   GENOMICS

H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes

(2018) Jie Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Involvement of H19/miR-326 axis in hepatocellular carcinoma development through modulating TWIST1

(2018) Li-Qing Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212

(2018) Fujun Yu et al.   Cell Death & Disease

Linking long noncoding RNA to control bile acid signaling and cholestatic liver fibrosis

(2017) John Y.L. Chiang   HEPATOLOGY

The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice

(2017) Xiaojiaoyang Li et al.   HEPATOLOGY

Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice

(2017) Kang Ho Kim et al.   HEPATOLOGY

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice

(2017) Oludemilade Akinrotimi et al.   HEPATOLOGY

H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule

(2017) Yongfeng Song et al.   HEPATOLOGY

SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer

(2017) Shruthy Suresh et al.   PLoS Genetics

Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis

(2017) Sabrina Cipriani et al.   Scientific Reports

Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay

(2016) Li Zhang et al.   HEPATOLOGY

A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2

(2016) Z. Yang et al.   MOLECULAR CANCER THERAPEUTICS

MeCP2 silencing of LncRNA H19 controls hepatic stellate cell proliferation by targeting IGF1R

(2016) Jing-Jing Yang et al.   TOXICOLOGY

Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

(2016) Zhiyun Ge et al.   eLife

Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function

(2016) Yuxia Zhang et al.   Scientific Reports

HULC and H19 Played Different Roles in Overall and Disease-Free Survival from Hepatocellular Carcinoma after Curative Hepatectomy: A Preliminary Analysis from Gene Expression Omnibus

(2015) Zongguo Yang et al.   DISEASE MARKERS

Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism

(2015) Sang Min Lee et al.   HEPATOLOGY

The knockdown of H19lncRNA reveals its regulatory role in pluripotency and tumorigenesis of human embryonic carcinoma cells

(2015) Evelyne Zeira et al.   Oncotarget

Non-coding RNA: what is functional and what is junk?

(2015) Alexander F. Palazzo et al.   Frontiers in Genetics

Regulation of Transcription by Long Noncoding RNAs

(2014) Roberto Bonasio et al.   Annual Review of Genetics

Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis

(2014) Yong He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-Coding RNAs: Multi-Tasking Molecules in the Cell

(2013) Anita Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-433 Inhibits Liver Cancer Cell Migration by Repressing the Protein Expression and Function of cAMP Response Element-binding Protein

(2013) Zhihong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

(2013) Jan-Wilhelm Kornfeld et al.   NATURE

H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1

(2013) P. Monnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEG3 noncoding RNA: a tumor suppressor

(2012) Yunli Zhou et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Loss of Imprinting and Allelic Switching at the DLK1-MEG3 Locus in Human Hepatocellular Carcinoma

(2012) Sumadi Lukman Anwar et al.   PLoS One

Nuclear receptor SHP inhibition of Dnmt1 expression via ERRγ

(2011) Yuxia Zhang et al.   FEBS LETTERS

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Role of nuclear receptor SHP in metabolism and cancer

(2010) Yuxia Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The H19 locus: Role of an imprinted non-coding RNA in growth and development

(2010) Anne Gabory et al.   BIOESSAYS

AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner

(2010) Ji-Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Receptor SHP, a Death Receptor That Targets Mitochondria, Induces Apoptosis and Inhibits Tumor Growth

(2010) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Interrelationship between Liver X Receptor α, Sterol Regulatory Element-binding Protein-1c, Peroxisome Proliferator-activated Receptor γ, and Small Heterodimer Partner in the Transcriptional Regulation of Glucokinase Gene Expression in Liver

(2009) Tae-Hyun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation

(2008) Yong-Soo Lee et al.   BIOCHEMICAL JOURNAL

Epigenetic Inhibition of Nuclear Receptor Small Heterodimer Partner Is Associated With and Regulates Hepatocellular Carcinoma Growth

(2008) Nan He et al.   GASTROENTEROLOGY

Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation

(2008) Yuxia Zhang et al.   HEPATOLOGY

Loss of small heterodimer partner expression in the liver protects against dyslipidemia

(2008) Helen B. Hartman et al.   JOURNAL OF LIPID RESEARCH