Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice

REV-ERBα Activates C/EBP Homologous Protein to Control Small Heterodimer Partner–Mediated Oscillation of Alcoholic Fatty Liver

(2016) Zhihong Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet

(2015) Xiaoying Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

(2015) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis

(2015) Motoko Sasaki et al.   JOURNAL OF GASTROENTEROLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes

(2014) Le Zhan et al.   PLoS One

Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo

(2014) C. M. Cremers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoregulation of Ire1 RNase splicing activity

(2014) Filippo Prischi et al.   Nature Communications

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

(2014) Jennifer L Mamrosh et al.   eLife

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

(2013) Quan Qiu et al.   EMBO JOURNAL

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

Unfolded Protein Response Signaling and Metabolic Diseases

(2013) Jaemin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FXR Agonist INT-747 Upregulates DDAH Expression and Enhances Insulin Sensitivity in High-Salt Fed Dahl Rats

(2013) Yohannes T. Ghebremariam et al.   PLoS One

Characterization of the Mitochondrial Localization of the Nuclear Receptor SHP and Regulation of Its Subcellular Distribution by Interaction with Bcl2 and HNF4α

(2013) Yuxia Zhang et al.   PLoS One

Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms

(2012) Danielle A.A. Hollman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

(2012) Bo Kong et al.   HEPATOLOGY

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

(2012) Kyu Yeon Hur et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

(2011) Maruf M U Ali et al.   EMBO JOURNAL

The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors

(2011) Jae-Min Yuk et al.   NATURE IMMUNOLOGY

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Role of nuclear receptor SHP in metabolism and cancer

(2010) Yuxia Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel Polymorphisms of Nuclear Receptor SHP Associated with Functional and Structural Changes

(2010) Taofeng Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice

(2010) Anne S. Henkel et al.   JOURNAL OF LIPID RESEARCH

Nuclear Receptor SHP, a Death Receptor That Targets Mitochondria, Induces Apoptosis and Inhibits Tumor Growth

(2010) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Imaging the Unfolded Protein Response in Primary Tumors Reveals Microenvironments with Metabolic Variations that Predict Tumor Growth

(2009) M. T. Spiotto et al.   CANCER RESEARCH

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

FXR: a metabolic regulator and cell protector

(2008) Yan-Dong Wang et al.   CELL RESEARCH

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Bile Acid-induced Apoptosis in Hepatocytes Is Caspase-6-dependent

(2008) Christian Rust et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress

(2008) Irina M Bochkis et al.   NATURE MEDICINE

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY