SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death

(2015) Lei Wang et al.   CANCER CELL

Vascular Endothelial Growth Factor C Disrupts the Endothelial Lymphatic Barrier to Promote Colorectal Cancer Invasion

(2015) Carlotta Tacconi et al.   GASTROENTEROLOGY

Coactivator SRC-2–dependent metabolic reprogramming mediates prostate cancer survival and metastasis

(2015) Subhamoy Dasgupta et al.   JOURNAL OF CLINICAL INVESTIGATION

Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading

(2015) Bokai Zhu et al.   MOLECULAR CELL

SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis

(2015) Tiffany Fleet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

(2015) Lars Grøntved et al.   Nature Communications

Genomic portrait of resectable hepatocellular carcinomas: Implications ofRB1andFGF19aberrations for patient stratification

(2014) Sung-Min Ahn et al.   HEPATOLOGY

Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway

(2014) Minoru Takahashi et al.   JOURNAL OF IMMUNOLOGY

Thyroid Hormone Signaling In Vivo Requires a Balance between Coactivators and Corepressors

(2014) K. R. Vella et al.   MOLECULAR AND CELLULAR BIOLOGY

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

Identifying and mitigating bias in next-generation sequencing methods for chromatin biology

(2014) Clifford A. Meyer et al.   NATURE REVIEWS GENETICS

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Thyroid Hormone Response Element Half-Site Organization and Its Effect on Thyroid Hormone Mediated Transcription

(2014) Martin A. Paquette et al.   PLoS One

Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies

(2014) Barbara R. Tschida et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Steroid receptor coactivators: servants and masters for control of systems metabolism

(2014) Erin Stashi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SRC-2 Is an Essential Coactivator for Orchestrating Metabolism and Circadian Rhythm

(2014) Erin Stashi et al.   Cell Reports

Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4

(2013) Hsiang-Cheng Chi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibroblast growth factor signaling in liver carcinogenesis

(2013) Dalbir S. Sandhu et al.   HEPATOLOGY

Genetics and epigenetics of liver cancer

(2013) Cigdem Ozen et al.   New Biotechnology

Downregulation of Steroid Receptor Coactivator-2 Modulates Estrogen-Responsive Genes and Stimulates Proliferation of MCF-7 Breast Cancer Cells

(2013) Ingvild S. Fenne et al.   PLoS One

Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice

(2013) Guodong Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis

(2013) Jesse D. Riordan et al.   PLoS Genetics

Hepatocellular Carcinoma: Important Biomarkers and their Significance in Molecular Diagnostics and Therapy

(2012) B. Sengupta et al.   CURRENT MEDICINAL CHEMISTRY

Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma

(2012) S Fatima et al.   ONCOGENE

A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer

(2012) K. A. O'Donnell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Energy Depletion Resets Whole-Body Energy by Promoting Coactivator-Mediated Dietary Fuel Absorption

(2011) Atul R. Chopra et al.   Cell Metabolism

Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells

(2011) Chen-Hsin Liao et al.   HEPATOLOGY

Steroid Receptor Coactivator (SRC) Family: Masters of Systems Biology

(2010) Brian York et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer and the Complement Cascade

(2010) M. J. Rutkowski et al.   MOLECULAR CANCER RESEARCH

Systems-level analysis of gene expression data revealed NR0B2/SHP as potential tumor suppressor in human liver cancer

(2010) Yun-Yong Park et al.   MOLECULES AND CELLS

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Transposon-based screens for cancer gene discovery in mouse models

(2010) Adam J. Dupuy   SEMINARS IN CANCER BIOLOGY

Nuclear Receptor Expression Defines a Set of Prognostic Biomarkers for Lung Cancer

(2010) Yangsik Jeong et al.   PLOS MEDICINE

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells

(2009) Shani Raveh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma

(2008) D. Y. Chiang et al.   CANCER RESEARCH

Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation

(2008) Yuxia Zhang et al.   HEPATOLOGY

Modulation of transcription parameters in glucocorticoid receptor-mediated repression

(2008) Yunguang Sun et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease

(2008) A. R. Chopra et al.   SCIENCE