Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts
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Title
Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts
Authors
Keywords
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Journal
Journal of Translational Medicine
Volume 19, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-05-04
DOI
10.1186/s12967-021-02860-z
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Note: Only part of the references are listed.- Role of STAT3 signaling pathway in breast cancer
- (2020) Jia-hui Ma et al. Cell Communication and Signaling
- Metformin Enhances the Antitumor Activity of CD8+ T Lymphocytes via the AMPK–miR-107–Eomes–PD-1 Pathway
- (2020) Zhen Zhang et al. JOURNAL OF IMMUNOLOGY
- Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells
- (2020) Juichiro Yoshida et al. ONCOLOGY REPORTS
- Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
- (2019) Sara Verdura et al. OncoImmunology
- Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg/Teff cells and reducing spleen germinal center formation
- (2019) Yanlin Wang et al. MOLECULAR IMMUNOLOGY
- Metformin enhances the immunomodulatory potential of adipose-derived mesenchymal stem cells through STAT1 in an animal model of lupus
- (2019) Se Gwang Jang et al. RHEUMATOLOGY
- Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells
- (2018) Qian Mu et al. OncoTargets and Therapy
- Metformin and Autoimmunity: A “New Deal” of an Old Drug
- (2018) Francesco Ursini et al. Frontiers in Immunology
- Interleukin-17-producing γδ T (γδ 17) cells in inflammatory diseases
- (2018) Aoi Akitsu et al. IMMUNOLOGY
- Lafora Disease: A Ubiquitination-Related Pathology
- (2018) Maria García-Gimeno et al. Cells
- Targeting Costimulatory Pathways in Systemic Sclerosis
- (2018) Gonçalo Boleto et al. Frontiers in Immunology
- Autologous Hematopoietic Stem Cell Transplantation for Treatment of Systemic Sclerosis
- (2018) Nicoletta Del Papa et al. Frontiers in Immunology
- Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs
- (2017) Ming-Min Chung et al. EXPERIMENTAL CELL RESEARCH
- The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases
- (2017) Taku Kuwabara et al. MEDIATORS OF INFLAMMATION
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- (2017) Daniel Garcia et al. MOLECULAR CELL
- Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response
- (2017) Suniti Bhaumik et al. Frontiers in Immunology
- Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management
- (2017) Arun Chaudhury et al. Frontiers in Endocrinology
- Metformin ameliorates the Phenotype Transition of Peritoneal Mesothelial Cells and Peritoneal Fibrosis via a modulation of Oxidative Stress
- (2017) Hyun-Soo Shin et al. Scientific Reports
- Vitamin D attenuates myofibroblast differentiation and extracellular matrix accumulation in nasal polyp-derived fibroblasts through smad2/3 signaling pathway
- (2017) Seoung-Ae Lee et al. Scientific Reports
- Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis
- (2017) Han-Shui Hsu et al. Scientific Reports
- Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer
- (2016) Reema Wahdan-Alaswad et al. CELL CYCLE
- Metformin - The Drug for the Treatment of Autoimmune Diseases; A New Use of a Known Anti-Diabetic Drug
- (2016) Malgorzata Tomczynska et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Oral Metformin Ameliorates Bleomycin-Induced Skin Fibrosis
- (2016) Francesco Ursini et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate–activated protein kinase-autophagy for the balance between T helper 17 and Tregs
- (2016) Min-Jung Park et al. Translational Research
- Activated IL-1RI Signaling Pathway Induces Th17 Cell Differentiation via Interferon Regulatory Factor 4 Signaling in Patients with Relapsing-Remitting Multiple Sclerosis
- (2016) Yonggang Sha et al. Frontiers in Immunology
- Pathogenesis of Systemic Sclerosis
- (2015) Debendra Pattanaik et al. Frontiers in Immunology
- Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance
- (2015) Seon-Yeong Lee et al. PLoS One
- Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
- (2014) Y Feng et al. Cell Death & Disease
- Interleukin-17 increases the expression of Toll-like receptor 3 via the STAT3 pathway in rheumatoid arthritis fibroblast-like synoviocytes
- (2013) Seon-Yeong Lee et al. IMMUNOLOGY
- IL-17A Induces Endothelial Inflammation in Systemic Sclerosis via the ERK Signaling Pathway
- (2013) Xiaojing Xing et al. PLoS One
- Clinical associations of serum interleukin-17 in systemic lupus erythematosus
- (2013) Fabien B Vincent et al. ARTHRITIS RESEARCH & THERAPY
- Metformin: an old but still the best treatment for type 2 diabetes
- (2013) Lilian Beatriz Aguayo Rojas et al. Diabetology & Metabolic Syndrome
- Potential roles of interleukin-17A in the development of skin fibrosis in mice
- (2012) Yoshinobu Okamoto et al. ARTHRITIS AND RHEUMATISM
- Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers
- (2012) Xin-Sheng Deng et al. CELL CYCLE
- Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation
- (2012) Ian P Salt et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
- (2012) W-Y Shi et al. Cell Death & Disease
- Scleroderma-like properties of skin from caveolin-1-deficient mice
- (2011) Remedios Castello-Cros et al. CELL CYCLE
- AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300
- (2011) Joong-Yeon Lim et al. JOURNAL OF CELLULAR PHYSIOLOGY
- IL-1 and TGF- Act Antagonistically in Induction and Differentially in Propagation of Human Proinflammatory Precursor CD4+ T Cells
- (2011) K. Hebel et al. JOURNAL OF IMMUNOLOGY
- Prevention of excessive collagen accumulation by human intravenous immunoglobulin treatment in a murine model of bleomycin-induced scleroderma
- (2010) M. Kajii et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes
- (2009) Timothy R. D. J. Radstake et al. PLoS One
- CD19 Regulates Skin and Lung Fibrosis via Toll-Like Receptor Signaling in a Model of Bleomycin-Induced Scleroderma
- (2008) Ayumi Yoshizaki et al. AMERICAN JOURNAL OF PATHOLOGY
- IL-21 and TGF-β are required for differentiation of human TH17 cells
- (2008) Li Yang et al. NATURE
- The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
- (2008) Nicolas Manel et al. NATURE IMMUNOLOGY
- IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
- (2008) M. Huber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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