Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models

(2012) Y. D. Kim et al.   DIABETOLOGIA

IKK biology

(2012) Fei Liu et al.   IMMUNOLOGICAL REVIEWS

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

(2012) Annemijn M Algra et al.   LANCET ONCOLOGY

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Isoform-selective 5′-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions

(2011) F. Spencer Gaskin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AMP-Activated Protein Kinase Suppresses Endothelial Cell Inflammation Through Phosphorylation of Transcriptional Coactivator p300

(2011) Yuan Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

α1AMP-Activated Protein Kinase Preserves Endothelial Function During Chronic Angiotensin II Treatment by Limiting Nox2 Upregulation

(2011) Swenja Schuhmacher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo

(2011) Young Min Kim et al.   ATHEROSCLEROSIS

Aspirin-induced AMP-activated protein kinase activation regulates the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats

(2011) Jin Young Sung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

(2011) Charlotte J. Green et al.   BIOCHEMICAL JOURNAL

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase

(2011) Charlotte J. Green et al.   DIABETES

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

(2011) Henning Walczak   IMMUNOLOGICAL REVIEWS

Energy-sensing Factors Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) and AMP-activated Protein Kinase Control Expression of Inflammatory Mediators in Liver

(2011) Marcin Buler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism

(2011) Nancie J. MacIver et al.   JOURNAL OF IMMUNOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Nitric Oxide-Induced Activation of the AMP-Activated Protein Kinase α2 Subunit Attenuates IκB Kinase Activity and Inflammatory Responses in Endothelial Cells

(2011) Elke Bess et al.   PLoS One

Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2

(2011) Qilong Wang et al.   PLoS One

Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation

(2011) Jean Grisouard et al.   Diabetology & Metabolic Syndrome

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo

(2010) Yunzhou Dong et al.   CIRCULATION

AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo

(2010) Shuangxi Wang et al.   CIRCULATION RESEARCH

Actual status of antiinterleukin-1 therapies in rheumatic diseases

(2010) Matthias Geyer et al.   CURRENT OPINION IN RHEUMATOLOGY

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)

(2010) A. Nerstedt et al.   DIABETOLOGIA

Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation

(2010) Zhiyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3)

(2010) Jeffrey A. Handy et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide Ribonucleoside with Protective Effect in Dextran Sulfate Sodium-Induced Acute and Chronic Colitis

(2010) A. Bai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF- B

(2010) X. D. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lymphocytes Accelerate Epithelial Tight Junction Assembly: Role of AMP-Activated Protein Kinase (AMPK)

(2010) Xiao Xiao Tang et al.   PLoS One

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMPKα1 regulates the antioxidant status of vascular endothelial cells

(2009) Sergio L. Colombo et al.   BIOCHEMICAL JOURNAL

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

(2009) Yonghao Cao et al.   CELL RESEARCH

Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells

(2009) A. Peairs et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-  Expression

(2009) D. Y.C. Yuen et al.   DIABETES

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

(2009) G. W.D. Landman et al.   DIABETES CARE

Targeting IL-6 in the treatment of inflammatory and autoimmune diseases

(2009) Changhai Ding et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes

(2009) Michael Karin et al.   IMMUNOLOGICAL REVIEWS

Regulation of Rac1 by Simvastatin in Endothelial Cells

(2009) Ruqin Kou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion

(2009) Dake Qi et al.   JOURNAL OF CLINICAL INVESTIGATION

Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation

(2009) Blerina Kola et al.   JOURNAL OF ENDOCRINOLOGY

Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis

(2009) N. Nath et al.   JOURNAL OF IMMUNOLOGY

A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling

(2009) Katiuscia Bianchi et al.   MOLECULAR CELL

Signal Transducer and Activator of Transcription 3 Is Required for Abnormal Proliferation and Survival of TSC2-Deficient Cells: Relevance to Pulmonary Lymphangioleiomyomatosis

(2009) E. A. Goncharova et al.   MOLECULAR PHARMACOLOGY

Control of NF- B-dependent Transcriptional Responses by Chromatin Organization

(2009) G. Natoli   Cold Spring Harbor Perspectives in Biology

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury

(2008) Xia Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of Tumor Necrosis Factor α–Stimulated Monocyte Adhesion to Human Aortic Endothelial Cells by AMP-Activated Protein Kinase

(2008) Marie-Ann Ewart et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

(2008) John W. Scott et al.   CHEMISTRY & BIOLOGY

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Molecular Mechanisms of Ghrelin-Mediated Endothelial Nitric Oxide Synthase Activation

(2008) Xiangbin Xu et al.   ENDOCRINOLOGY

AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function

(2008) Alice Mayer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metformin inhibits TNF-α-induced IκB kinase phosphorylation, IκB-α degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation

(2008) Nan-Lan Huang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression

(2008) Bysani Chandrasekar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

(2008) Tao Pang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase

(2007) Chih-Lin Kuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY