Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy

Inflammatory bowel disease associated with the combination treatment of nivolumab and metformin: data from the FDA adverse event reporting system

(2019) Huaqiang Zhou et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable

(2019) Alessio Cortellini et al.   Journal for ImmunoTherapy of Cancer

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

(2019) Heidi M. Haikala et al.   Nature Communications

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

Defining the immunogram of breast cancer: a focus on clinical trials

(2019) Paolo Tarantino et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Immune-related adverse events predict the therapeutic efficacy of anti–PD-1 antibodies in cancer patients

(2019) J. Rogado et al.   EUROPEAN JOURNAL OF CANCER

Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients

(2019) Elisabet Cuyàs et al.   Aging-US

Epigenetic effects of metformin: From molecular mechanisms to clinical implications

(2018) Stephanie Claire Bridgeman et al.   DIABETES OBESITY & METABOLISM

Regulation of Programmed Death Ligand 1 (PD-L1) Expression in Breast Cancer Cell Lines In Vitro and in Immunodeficient and Humanized Tumor Mice

(2018) Eva-Maria Rom-Jurek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiome modulates efficacy of immune checkpoint inhibitors

(2018) Ming Yi et al.   Journal of Hematology & Oncology

Metabolic Barriers to T Cell Function in Tumors

(2018) Ayaka Sugiura et al.   JOURNAL OF IMMUNOLOGY

Metformin Suppresses Tumor Progression by Inactivating Stromal Fibroblasts in Ovarian Cancer

(2018) Sen Xu et al.   MOLECULAR CANCER THERAPEUTICS

The gut microbiota influences anticancer immunosurveillance and general health

(2018) Bertrand Routy et al.   Nature Reviews Clinical Oncology

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response

(2018) Felipe V. Pereira et al.   Oncotarget

Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion

(2018) Yiting Wang et al.   Frontiers in Pharmacology

Efficacy of metformin in combination with immune checkpoint inhibitors (anti-PD-1/anti-CTLA-4) in metastatic malignant melanoma

(2018) Muhammad Zubair Afzal et al.   Journal for ImmunoTherapy of Cancer

Pushing the Limits of Cancer Therapy: The Nutrient Game

(2018) Daniele Lettieri-Barbato et al.   Frontiers in Oncology

Study Protocol: Phase-Ib Trial of Nivolumab Combined With Metformin for Refractory/Recurrent Solid Tumors

(2018) Toshio Kubo et al.   Clinical Lung Cancer

Immunometabolism in cancer at a glance

(2018) Katrin Singer et al.   Disease Models & Mechanisms

The Cancer Immunogram as a Framework for Personalized Immunotherapy in Urothelial Cancer

(2018) Nick van Dijk et al.   EUROPEAN UROLOGY

ERADicate Tumor Progression with Metformin

(2018) Lena-Sophie Dreher et al.   MOLECULAR CELL

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Inhibitory Effect of Anoectochilus formosanus Extract on Hyperglycemia-Related PD-L1 Expression and Cancer Proliferation

(2018) Yih Ho et al.   Frontiers in Pharmacology

Tumor mutational burden is a determinant of immune-mediated survival in breast cancer

(2018) Alexandra Thomas et al.   OncoImmunology

Diabetic ketoacidosis induced by a single dose of pembrolizumab

(2018) Julian Maamari et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Undo the brake of tumour immune tolerance with antibodies, peptides and small molecule compounds targeting PD-1/PD-L1 checkpoint at different locations for acceleration of cytotoxic immunity to cancer cells

(2018) Wenyi Gu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Cancer Immunogram: A Pledge for a Comprehensive Biomarker Approach for Personalized Immunotherapy in Urothelial Cancer

(2018) Haris Zahoor et al.   EUROPEAN UROLOGY

Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects

(2018) Takenori Uehara et al.   INTERNATIONAL IMMUNOLOGY

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

(2018) Toszka Bohn et al.   NATURE IMMUNOLOGY

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

A phase 2 trial of neoadjuvant metformin in combination with trastuzumab and chemotherapy in women with early HER2-positive breast cancer: the METTEN study

(2018) Begoña Martin-Castillo et al.   Oncotarget

Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes

(2017) Katrina E. Allison et al.   IMMUNOLOGY

An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer

(2017) Takahiro Karasaki et al.   Journal of Thoracic Oncology

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

(2017) Riccardo Mezzadra et al.   NATURE

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Gut microbiota modulation of chemotherapy efficacy and toxicity

(2017) James L. Alexander et al.   Nature Reviews Gastroenterology & Hepatology

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism

(2017) E Cuyàs et al.   ONCOGENE

Molecular Biomarkers of Primary and Acquired Resistance to T‐Cell‐Mediated Immunotherapy in Cancer: Landscape, Clinical Implications, and Future Directions

(2017) Young Kwang Chae et al.   ONCOLOGIST

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

PD-L1/PD-1: new kid on the “immune metabolic” block

(2017) Mirjeta Qorraj et al.   Oncotarget

Metformin: a metabolic modulator

(2017) Federico Pietrocola et al.   Oncotarget

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

(2017) Kathrin Renner et al.   Frontiers in Immunology

Combined checkpoint inhibitor therapy causing diabetic ketoacidosis in metastatic melanoma

(2017) Pouyan N. Changizzadeh et al.   Journal for ImmunoTherapy of Cancer

Nivolumab-induced autoimmune diabetes mellitus presenting as diabetic ketoacidosis in a patient with metastatic lung cancer

(2017) James Luke Godwin et al.   Journal for ImmunoTherapy of Cancer

Attenuation of CD4 + CD25 + Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

(2017) Yuki Kunisada et al.   EBioMedicine

Gut Microbiota, Inflammation, and Colorectal Cancer

(2016) Caitlin A. Brennan et al.   Annual Review of Microbiology

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

(2016) Lianfeng Wu et al.   CELL

Metformin targets histone acetylation in cancer-prone epithelial cells

(2016) Elisabet Cuyàs et al.   CELL CYCLE

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling

(2016) H. L. McArthur et al.   CLINICAL CANCER RESEARCH

Dual Faces of IFN  in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity

(2016) M. Mandai et al.   CLINICAL CANCER RESEARCH

Metformin Is Associated With Higher Relative Abundance of Mucin-DegradingAkkermansia muciniphilaand Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

(2016) Jacobo de la Cuesta-Zuluaga et al.   DIABETES CARE

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

(2016) Keisuke Kataoka et al.   NATURE

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

The "cancer immunogram"

(2016) C. U. Blank et al.   SCIENCE

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

(2016) Ping-Chih Ho et al.   Journal for ImmunoTherapy of Cancer

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

(2016) Bruna Corominas-Faja et al.   Aging-US

Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

(2015) Kristin J. Lastwika et al.   CANCER RESEARCH

Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial

(2015) Sil Kordes et al.   LANCET ONCOLOGY

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

(2015) Brian J Laidlaw et al.   NATURE IMMUNOLOGY

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

(2015) Shingo Eikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Ebola vaccine R&D: Filling the knowledge gaps

(2015) Donata Medaglini et al.   Science Translational Medicine

Confusing signals: Recent progress in CTLA-4 biology

(2015) Lucy S.K. Walker et al.   TRENDS IN IMMUNOLOGY

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

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(2015)   Oncotarget

Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

(2015) Zaid Al-Wahab et al.   Oncotarget

Metformin: Multi-faceted protection against cancer

(2015) Sonia Del Barco et al.   Oncotarget

Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial

(2014) Andrea DeCensi et al.   BREAST CANCER RESEARCH AND TREATMENT

Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression

(2014) Chunxiao Xu et al.   CANCER CELL

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer

(2014) Kevin M. Schuler et al.   Cancer Medicine

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Tumor-specific CD4+T cells maintain effector and memory tumor-specific CD8+T cells

(2013) Sarah E. Church et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Treg and CTLA-4: Two intertwining pathways to immune tolerance

(2013) Lucy S.K. Walker   JOURNAL OF AUTOIMMUNITY

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

(2013) H. A. Hirsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strength of PD-1 signaling differentially affects T-cell effector functions

(2013) F. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Metformin and breast cancer risk: a meta-analysis and critical literature review

(2012) Nananda F. Col et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformation

(2012) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Dual Effect of Metformin on Breast Cancer Proliferation in a Randomized Presurgical Trial

(2012) Bernardo Bonanni et al.   JOURNAL OF CLINICAL ONCOLOGY

Enzymatic Discovery of a HER-2/neu Epitope That Generates Cross-Reactive T Cells

(2012) A. M. Henle et al.   JOURNAL OF IMMUNOLOGY

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

(2012) Michael N. Pollak   Cancer Discovery

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients

(2011) Praveen Kumar Munipally et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

(2010) Pamela J. Goodwin et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

The role of mTOR in memory CD8+ T-cell differentiation

(2010) Koichi Araki et al.   IMMUNOLOGICAL REVIEWS

A metabolic switch to memory

(2009) Martin Prlic et al.   NATURE

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA