Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

(2020) Bo Pan et al.   CIRCULATION RESEARCH

Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations

(2020) Rachel S. Donocoff et al.   Scientific Reports

Underestimated Peripheral Effects Following Pharmacological and Conditional Genetic Microglial Depletion

(2020) Jinming Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual Functions of Microglia in Ischemic Stroke

(2019) Chuan Qin et al.   Neuroscience Bulletin

Global brain inflammation in stroke

(2019) Kaibin Shi et al.   LANCET NEUROLOGY

Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress

(2019) Bo Pan et al.   Frontiers in Physiology

mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP

(2019) Yaling Hu et al.   GLIA

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

(2018) Xiaoxia Yang et al.   FASEB JOURNAL

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour

(2018) Jessica M. Rosin et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia may compensate for dopaminergic neuron loss in experimental Parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus

(2017) Hitomi Aono et al.   GLIA

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke

(2016) Dai-Shi Tian et al.   JOURNAL OF NEUROCHEMISTRY

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Perfusion computed tomography to assist decision making for stroke thrombolysis

(2015) Andrew Bivard et al.   BRAIN

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

(2015) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study

(2015) Xuya Huang et al.   LANCET NEUROLOGY

Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation

(2015) Guangyun Zhang et al.   MOLECULAR NEUROBIOLOGY

STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis

(2015) Yaoqian Pan et al.   NEUROPHARMACOLOGY

HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats

(2015) Q.J. Shi et al.   NEUROSCIENCE

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

Inhibition of mitogen-activated protein kinase phosphatase-1 (MKP-1) increases experimental stroke injury

(2014) Lin Liu et al.   EXPERIMENTAL NEUROLOGY

Microglia is a Key Player in the Reduction of Stroke Damage Promoted by the New Antithrombotic Agent Ticagrelor

(2014) Paolo Gelosa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Toll-Like Receptor 2 Deficiency Shifts PrP106-126-Induced Microglial Activation from a Neurotoxic to a Neuroprotective Phenotype

(2014) Jihong Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption

(2014) Tengyuan Liu et al.   Journal of Neuroinflammation

RAGE Inhibition in Microglia Prevents Ischemia-Dependent Synaptic Dysfunction in an Amyloid-Enriched Environment

(2014) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Acute Reduction of Microglia Does Not Alter Axonal Injury in a Mouse Model of Repetitive Concussive Traumatic Brain Injury

(2014) Rachel E. Bennett et al.   JOURNAL OF NEUROTRAUMA

The Relationship Between Serial [18 F]PBR06 PET Imaging of Microglial Activation and Motor Function Following Stroke in Mice

(2014) Frederick M. Lartey et al.   MOLECULAR IMAGING AND BIOLOGY

c-Abl Tyrosine Kinase Mediates Neurotoxic Prion Peptide-Induced Neuronal Apoptosis via Regulating Mitochondrial Homeostasis

(2014) Bo Pan et al.   MOLECULAR NEUROBIOLOGY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1 via Nuclear Factor Erythroid-2-Related Factor 2

(2013) Esther Parada et al.   ANTIOXIDANTS & REDOX SIGNALING

Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

(2013) Ting Li et al.   BRAIN

Preconditioning to mild oxidative stress mediates astroglial neuroprotection in an IL-10-dependent manner

(2013) Niva Segev-Amzaleg et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Effect of stroke on arginase expression and localization in the rat brain

(2013) Aurore Quirié et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Selective Neuronal Loss in Ischemic Stroke and Cerebrovascular Disease

(2013) Jean-Claude Baron et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia

(2013) S. M. Lloyd-Burton et al.   JOURNAL OF NEUROSCIENCE

Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury

(2012) M. Lalancette-Hebert et al.   JOURNAL OF NEUROSCIENCE

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

Early-activated microglia play a role in transient forebrain ischemia-induced neural precursor proliferation in the dentate gyrus of mice

(2010) Dong Hyun Kim et al.   NEUROSCIENCE LETTERS

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Human Microglia Transplanted in Rat Focal Ischemia Brain Induce Neuroprotection and Behavioral Improvement

(2010) Dashdemberel Narantuya et al.   PLoS One

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Immunotoxic depletion of microglia in mouse hippocampal slice cultures enhances ischemia-like neurodegeneration

(2009) Maria Montero et al.   BRAIN RESEARCH

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke

(2008) Pär Thored et al.   GLIA

Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege

(2008) J. Neumann et al.   JOURNAL OF NEUROSCIENCE

Stroke

(2008) Geoffrey A Donnan et al.   LANCET