The DpdtbA induced EMT inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2/hif-1α pathway

Resveratrol Counteracts Hypoxia-Induced Gastric Cancer Invasion and EMT through Hedgehog Pathway Suppression

(2020) Qin-Hong Xu et al.   Anti-Cancer Agents in Medicinal Chemistry

DpdtC-Induced EMT Inhibition in MGC-803 Cells Was Partly through Ferritinophagy-Mediated ROS/p53 Pathway

(2020) Jiankang Feng et al.   Oxidative Medicine and Cellular Longevity

The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway

(2020) Zhongjie Xu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aspirin suppresses tumor cell-induced angiogenesis and their incongruity

(2019) Gargi Maity et al.   Journal of Cell Communication and Signaling

Ferritinophagic Flux Activation in CT26 Cells Contributed to EMT Inhibition Induced by a Novel Iron Chelator, DpdtpA

(2019) Yanjie Sun et al.   Oxidative Medicine and Cellular Longevity

DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway

(2019) Zhuo Wang et al.   Oxidative Medicine and Cellular Longevity

Deferoxamine: An Angiogenic and Antioxidant Molecule for Tissue Regeneration

(2019) Paige Holden et al.   TISSUE ENGINEERING PART B-REVIEWS

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

(2019) Loh et al.   Cells

Extracellular Matrix Alterations in Metastatic Processes

(2019) Paolillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PHD2 exerts anti-cancer and anti-inflammatory effects in colon cancer xenografts mice via attenuating NF-κB activity

(2019) Li Wang et al.   LIFE SCIENCES

Di-2-pyridylhydrazone Dithiocarbamate Butyric Acid Ester Exerted Its Proliferative Inhibition against Gastric Cell via ROS-Mediated Apoptosis and Autophagy

(2018) Xingshuang Guo et al.   Oxidative Medicine and Cellular Longevity

Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation

(2018) Tengfei Huang et al.   Oxidative Medicine and Cellular Longevity

Understanding the molecular mechanisms driving metastasis

(2017) Joan Massagué et al.   Molecular Oncology

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

(2017) Shumei Ma et al.   PLoS One

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

(2017) Anna L Miles et al.   eLife

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Hypoxia Induced NF-κB

(2016) Laura D’Ignazio et al.   Cells

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation

(2016) Gibok Lee et al.   Scientific Reports

Modeling the interplay between the HIF-1 and p53 pathways in hypoxia

(2015) Chun-Hong Zhou et al.   Scientific Reports

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

(2015) Isabel Siegert et al.   Cell Reports

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair

(2014) Kelly E. Johnson et al.   Advances in Wound Care

Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer

(2013) Faton Agani et al.   CURRENT CANCER DRUG TARGETS

Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

(2013) Timur R Samatov et al.   Molecular Cancer

Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

(2012) Sreenivasulu Chintala et al.   BMC CANCER

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia

(2012) Helene Niecknig et al.   FREE RADICAL RESEARCH

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

(2012) Dennis L. Buckley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

EMT and Oxidative Stress: A Bidirectional Interplay Affecting Tumor Malignancy

(2011) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Importance of Iron Chelation in Free Radical-Induced Oxidative Stress and Human Disease

(2011) Klaudia Jomova et al.   CURRENT PHARMACEUTICAL DESIGN

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Epithelial–mesenchymal transition and the invasive potential of tumors

(2008) Nancy Gavert et al.   TRENDS IN MOLECULAR MEDICINE