Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

VHLGenetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin

(2015) Michelle J. Nyhan et al.   Analytical Cellular Pathology

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Methylseleninic acid inhibits HDAC activity in diffuse large B-cell lymphoma cell lines

(2011) Shireen Kassam et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads

(2011) Annamaria Rapisarda et al.   CELL CYCLE

Methylseleninic acid downregulates hypoxia-inducible factor-1α in invasive prostate cancer

(2011) Indu Sinha et al.   INTERNATIONAL JOURNAL OF CANCER

Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)

(2011) Rasheduzzaman Chowdhury et al.   JOURNAL OF MOLECULAR BIOLOGY

Aberrant Promoter CpG Methylation Is a Mechanism for Impaired PHD3 Expression in a Diverse Set of Malignant Cells

(2011) Trenton L. Place et al.   PLoS One

Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells

(2010) Ying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

(2010) Jacqueline Kessler et al.   BMC CANCER

PHD2 in tumour angiogenesis

(2010) D A Chan et al.   BRITISH JOURNAL OF CANCER

Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α

(2010) Sreenivasulu Chintala et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

(2010) D. Astuti et al.   ENDOCRINE-RELATED CANCER

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

(2010) Daniel A. Tennant et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2  in Clear Cell Renal Carcinoma

(2010) H.-S. Kong et al.   MOLECULAR PHARMACOLOGY

Treatment of metastatic renal cell carcinoma

(2010) Maxine Sun et al.   Nature Reviews Urology

Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification

(2010) Qiliang Cai et al.   PLoS One

Double Immunohistochemical Staining Method for HIF-1α and its Regulators PHD2 and PHD3 in Formalin-fixed Paraffin-embedded Tissues

(2010) Mary M. Vaughan et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

BRCA1 tumours correlate with a HIF-1α phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression

(2009) M Yan et al.   BRITISH JOURNAL OF CANCER

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

(2009) Denise A. Chan et al.   CANCER CELL

HIF-1 Inhibitors for Cancer Therapy: From Gene Expression to Drug Discovery

(2009) G. Semenza   CURRENT PHARMACEUTICAL DESIGN

HIF Prolyl-4-hydroxylase Interacting Proteins: Consequences for Drug Targeting

(2009) Roland Wenger et al.   CURRENT PHARMACEUTICAL DESIGN

The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia

(2009) Eleftheria Hatzimichael et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

(2008) John D. Gordan et al.   CANCER CELL

Tumor Vascular Maturation and Improved Drug Delivery Induced by Methylselenocysteine Leads to Therapeutic Synergy with Anticancer Drugs

(2008) A. Bhattacharya et al.   CLINICAL CANCER RESEARCH

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

(2008) Scott M. Lippman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA