Article
Cell Biology
Peng Zhang, Liang Chen, Fenfang Zhou, Zhiwen He, Gang Wang, Yongwen Luo
Summary: Prostate cancer (PCa) is a common male malignancy with unclear progression mechanisms. This study found that NRP1, highly expressed in PCa, was associated with poor prognosis in PCa patients. Functionally, NRP1 depletion inhibited PCa cell proliferation and migration, while NRP1 overexpression promoted these processes. Mechanistically, NRP1 was regulated by HIF1 alpha and interacted with EGFR, leading to EGFR phosphorylation and activation of the AKT signaling pathway, promoting PCa progression. Additionally, the NRP1 inhibitor EG01377 inactivated the EGFR/AKT signaling axis and suppressed PCa progression.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Ke Huang, Wei Zhao, Xuqiao Wang, Yingfei Qiu, Zelin Liu, Rui Chen, Wei Liu, Bin Liu
Summary: The study found that low-dose heavy-ion radiation had minimal growth inhibition effects on C6 cells, while Akt inhibition induced by perifosine enhanced the growth inhibition effects.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kendall Dutchak, Sam Garnett, Mary Nicoll, Angeline de Bruyns, David Dankort
Summary: Activation of the RTK-RAS-RAF-MEK-ERK pathway is common in human cancers, but it usually leads to senescence in primary cells. Through screening, MOB3A was identified as a protein that allows proliferation and suppresses senescence in response to oncogenic RAS and BRAF signals. MOB3A acts by inhibiting Hippo signaling and its sustained membrane localization mimics the bypass of oncogene-induced senescence seen with elevated YAP expression.
MOLECULAR CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Vaishnavi K. Nimbalkar, Jeet Gangar, Saptarsi Shai, Pallavi Rane, Subham Kumar Mohanta, Sadhana Kannan, Arvind Ingle, Neha Mittal, Swapnil Rane, Manoj B. Mahimkar
Summary: This study investigates the potential of polymeric black tea polyphenols (PBPs) in oral cancer chemoprevention and reveals their ability to modulate the EGFR pathway, resulting in reduced tumor growth and oxidative DNA damage, inflammation, and cell proliferation, as well as increased apoptosis. These findings provide experimental evidence for the preclinical chemopreventive efficacy of PBPs.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Jiamin Zhang, Shu Fang, Fanghao Rong, Miaomiao Jia, Yunpeng Wang, Huixian Cui, Peipei Hao
Summary: The upregulated expression of PSMD4 in hepatocellular carcinoma (HCC) is associated with poor prognosis. PSMD4 mediates cell growth through COX2 expression and p53 downregulation, and is maintained by inflammatory factors secreted from tumor matrix cells. Inhibition of PSMD4 suppresses tumor development in a mouse xenograft model. Therapeutic strategies targeting PSMD4 and its downstream effectors could be used for treating PSMD4-abundant HCC patients.
Article
Oncology
Mikkel G. Terp, Kirstine Jacobsen, Miguel Angel Molina, Niki Karachaliou, Hans C. Beck, Jordi Bertran-Alamillo, Ana Gimenez-Capitan, Andres F. Cardona, Rafael Rosell, Henrik J. Ditzel
Summary: Resistance to EGFR tyrosine kinase inhibitors (TKIs) in NSCLC patients is often associated with increased FGFR1 expression and Akt activation, leading to the development of targeted therapy strategies for overcoming resistance. Combination therapy targeting both FGFR and Akt has shown superior growth inhibition of resistant cells in vitro and in vivo, providing a promising rationale for future clinical trials in NSCLC patients.
NPJ PRECISION ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Bin Xu, Jie Mei, Wei Ji, Zhengyuan Huo, Zheng Bian, Jiantong Jiao, Xiaoqing Li, Jun Sun, Junfei Shao
Summary: GBM is the most common primary malignant tumor in adults with limited treatment options, and miRNAs play a key role in regulating the EGFR signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Bo Zhang, Yao Zhang, Xizi Jiang, Hongbo Su, Qiongzi Wang, Muli Wudu, Jun Jiang, Hongjiu Ren, Yitong Xu, Zongang Liu, Xueshan Qiu
Summary: JMJD8 functions as an oncogenic regulator in non-small-cell lung cancer (NSCLC), promoting carcinogenic activity by stabilizing EGFR and activating the downstream PI3K/AKT signaling pathway. High expression of JMJD8 is associated with the malignancy and staging of NSCLC patients.
Article
Pharmacology & Pharmacy
Xiao-qiang Li, Bo-Chuan Liu, Xiao-bing Jiang, Wen-wen Gao, Bo Rong, Yao Wei, Feng-lu Wang, Hai-kang Zhao, Liang Zhang
Summary: The study reveals that up-regulation of PTPN21 is correlated with glioma and predicts poor survival rate in patients. Silencing PTPN21 has significant anti-cancer effects in glioma cells, inhibiting proliferation, arresting cell cycle, suppressing metastasis, and enhancing chemosensitivity. Mechanistically, PTPN21 mediates the EGFR/PI3K/AKT pathway in glioma.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Environmental Sciences
Meichen Zhang, Zaihong Zhang, Qun Lou, Xin Zhang, Fanshuo Yin, Yunyi Yin, Haili Xu, Ying Zhang, Chenlu Fan, Yanhui Gao, Yanmei Yang
Summary: Arsenic, a known human carcinogen, induces cell proliferation at low doses, but the underlying mechanism is unclear. This study found that the SIRT1/P53 pathway is involved in arsenic-induced glycolysis by regulating HK2 expression in L-02 cells. SIRT1 not only inhibits P53 expression, but also reduces acetylation of P53-K382 in arsenic-treated L-02 cells. Additionally, SIRT1 influences the expression of HK2 and LDHA, promoting arsenic-induced glycolysis in L-02 cells. These findings provide a theoretical basis for understanding the mechanism of arsenic carcinogenesis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Se Jin Oh, Ji Yeon Lim, Min Kyu Son, Jun Hyeok Ahn, Kwon-Ho Song, Hyo-Jung Lee, Suyeon Kim, Eun Ho Cho, Joon-Yong Chung, Hanbyoul Cho, Hyosun Kim, Jae-Hoon Kim, Jooyoung Park, Jungmin Choi, Sun Wook Hwang, Tae Woo Kim
Summary: The emergence of cisplatin resistance and side-effects are important factors in cancer treatment failure. The authors identify autophagy-mediated EGFR hyperactivation by TRPV1 promotion as a mechanism of cisplatin resistance and demonstrate the efficacy of a TRPV1 inhibitor to sensitize lung cancer to cisplatin. Future studies should provide evidence regarding the mechanisms of potential targets that can overcome the resistance as well as alleviate pain.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xiaohui Hao, Yixuan Jin, Yiyang Zhang, Shifeng Li, Jie Cui, Hailan He, Lingli Guo, Fang Yang, Heliang Liu
Summary: Studies have shown that c-Src regulates the development of silicosis-induced lung fibrosis through the PI3K/AKT pathway, and Src kinase inhibitors may be potentially effective for the treatment of silicosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Dongshao Chen, Ruoxi Hong, Youjun Cao, Qingnan Wu, Yan Wang, Jie Chen, Jinting Li, Weimin Zhang, Qimin Zhan
Summary: This study found that dual blockage of EGFR and Wee1 inhibited tumor growth in ESCC partially through PI3K/Akt or MAPK pathway blockade and inducing apoptosis. Meanwhile, the POLR2A might be candidate molecule of EGFR/Wee1 downstream.
Article
Endocrinology & Metabolism
Yue Shen, Chenxing Ji, Xuemin Jian, Juan Zhou, Qilin Zhang, Nidan Qiao, Yichao Zhang, Xuefei Shou, Xiang Zhou, Zengyi Ma
Summary: The HSP90 inhibitor 17-AAG was found to reduce the viability and secretory function of human pituitary ACTH-secreting tumor cells, with a stronger inhibitory effect on tumor cells carrying the USP8 mutant compared to those carrying wild-type USP8. 17-AAG could be a potential treatment option for Cushing's disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Tao Liu, Wan Xiang, Zhizhuang Chen, Gang Wang, Rui Cao, Fenfang Zhou, Zhe Meng, Yongwen Luo, Liang Chen
Summary: This study found that hypoxia is elevated in ccRCC and may be an independent risk factor for prognosis in ccRCC patients. The study also revealed that PLOD2 is transcriptionally activated by HIF1A, interacts with EGFR, and ultimately promotes the malignant progression of ccRCC by activating the AKT signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Tingting Wang, Yun Fu, Tengfei Huang, Youxun Liu, Meihao Wu, Yanbin Yuan, Shaoshan Li, Changzheng Li
Article
Cell Biology
Xingshuang Guo, Yun Fu, Zhuo Wang, Tingting Wang, Cuiping Li, Tengfei Huang, Fulian Gao, Changzheng Li
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Cell Biology
Tengfei Huang, Yanjie Sun, Yongli Li, Tingting Wang, Yun Fu, Cuiping Li, Changzheng Li
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Cell Biology
Yongli Li, Tingting Wang, Yanjie Sun, Tengfei Huang, Cuiping Li, Yun Fu, Yichun Li, Changzheng Li
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cell Biology
Yanjie Sun, Cuiping Li, Jiankang Feng, Yongli Li, Xinbo Zhai, Lei Zhang, Changzheng Li
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Multidisciplinary Sciences
Yongli Li, Tengfei Huang, Yun Fu, Tingting Wang, Tiesuo Zhao, Sheng Guo, Yanjie Sun, Yun Yang, Changzheng Li
Article
Cell Biology
Jiankang Feng, Cuiping Li, Ruifang Xu, Yongli Li, Qi Hou, Rui Feng, Senye Wang, Lei Zhang, Changzheng Li
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biochemistry & Molecular Biology
Cuiping Li, Yongli Li, Liying Lou, Xinyi Han, Huihui Wang, Tengfei Huang, Changzheng Li
Summary: The study found that the combined treatment of exogenous LCN2 and DpdtC significantly inhibited the proliferation and metastasis of HepG2 cells. The interaction between LCN2 and DpdtC may impact their respective functions and shed light on the contradictory role of LCN2 in cancer metastasis.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Review
Oncology
Zhuo Wang, Tingting Zhao, Shihui Zhang, Junkai Wang, Yunyun Chen, Hongzhou Zhao, Yaxin Yang, Songlin Shi, Qiang Chen, Kuancan Liu
Summary: Wnt signaling plays important roles in tissue development, homeostasis maintenance, tumorigenesis, and cancer progression. Abnormal expression of signaling components is associated with tumor progression and poor prognosis, and the pathway also influences the tumor microenvironment and immune response. Drugs targeting the Wnt pathway offer multiple therapeutic values.
BIOMARKER RESEARCH
(2021)
Article
Cell Biology
Longlong Li, Hao Li, Yongli Li, Jiankang Feng, Deng Guan, Yalei Zhang, Yun Fu, Shaoshan Li, Changzheng Li
Summary: The study identified that the dithiocarbamate derivative PdtaA possesses anti-tumor properties by inducing ferritinophagy-related ROS production, leading to apoptosis, cell cycle arrest, and ferroptosis. This induction of ferroptosis, involving downregulation of GPx4 and xCT, and association with ROS production, represents a novel mechanism of action for a dithiocarbamate derivative.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Oncology
Hao Li, Wei Zhou, Huiping Wei, Longlong Li, Xu Wang, Yongli Li, Shaoshan Li, Changzheng Li
Summary: The strength of ferritinophagic flux plays a crucial role in regulating EMT and ferroptosis processes, affecting ROS production, modulation of related proteins, and induction of ferroptosis. This study also found that NDRG1 activation is involved in ferroptosis induction, highlighting the complex interplay between ferritinophagy, EMT, and ferroptosis.
JOURNAL OF ONCOLOGY
(2021)