Proprotein Convertase Is the Highest-Level Activator of the Alternative Complement Pathway in the Blood

Serum furin as a biomarker of high blood pressure: findings from a longitudinal study in Chinese adults

(2019) Yan He et al.   HYPERTENSION RESEARCH

Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway

(2019) Manabu Hayashi et al.   JOURNAL OF IMMUNOLOGY

Is generation of C3(H2O) necessary for activation of the alternative pathway in real life?

(2019) Kristina N. Ekdahl et al.   MOLECULAR IMMUNOLOGY

Serum PCSK6 and corin levels are not associated with cardiovascular outcomes in patients undergoing coronary angiography

(2019) Shang-Feng Yang et al.   PLoS One

Functional analysis of corin protein domains required for PCSK6-mediated activation

(2018) Shenghan Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Analysis of Factor D Isoforms in Malpuech–Michels–Mingarelli–Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement

(2017) Rasmus Pihl et al.   JOURNAL OF IMMUNOLOGY

Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism

(2017) Gábor Oroszlán et al.   Frontiers in Immunology

A journey through the lectin pathway of complement-MBL and beyond

(2016) Peter Garred et al.   IMMUNOLOGICAL REVIEWS

The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond

(2016) József Dobó et al.   IMMUNOLOGICAL REVIEWS

Mannan-Binding Lectin–Associated Serine Protease 1/3 Cleavage of Pro–Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference–Mediated Gene Silencing

(2016) Nirmal K. Banda et al.   JOURNAL OF IMMUNOLOGY

MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked

(2016) József Dobó et al.   Scientific Reports

MASP-1 and MASP-2 Do Not Activate Pro–Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors

(2015) Gábor Oroszlán et al.   JOURNAL OF IMMUNOLOGY

PCSK6-mediated corin activation is essential for normal blood pressure

(2015) Shenghan Chen et al.   NATURE MEDICINE

Serum MASP-1 in complex with MBL activates endothelial cells

(2014) Márton Megyeri et al.   MOLECULAR IMMUNOLOGY

Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation

(2014) Katalin Paréj et al.   MOLECULAR IMMUNOLOGY

Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway

(2013) Márton Megyeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2

(2012) Dávid Héja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function

(2012) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: Two genes, five proteins and many functions?

(2011) Tang Yongqing et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway

(2011) D. Iwaki et al.   JOURNAL OF IMMUNOLOGY

Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system

(2010) Søren E. Degn et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Ficolins and FIBCD1: Soluble and membrane bound pattern recognition molecules with acetyl group selectivity

(2010) Theresa Thomsen et al.   MOLECULAR IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Complement factor D, a novel serine protease

(2010) John E. Volanakis et al.   PROTEIN SCIENCE

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation

(2009) Mikkel-Ole Skjoedt et al.   IMMUNOBIOLOGY

MASP-1, a Promiscuous Complement Protease: Structure of Its Catalytic Region Reveals the Basis of Its Broad Specificity

(2009) J. Dobo et al.   JOURNAL OF IMMUNOLOGY

Purification, crystallization and preliminary X-ray analysis of human mannose-binding lectin-associated serine protease-1 (MASP-1) catalytic region

(2008) József Dobó et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications