The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond

The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation

(2016) H. Kozarcanin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Complement MASP-1 enhances adhesion between endothelial cells and neutrophils by up-regulating E‐selectin expression

(2016) Péter K. Jani et al.   MOLECULAR IMMUNOLOGY

MASP-1 and MASP-2 Do Not Activate Pro–Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors

(2015) Gábor Oroszlán et al.   JOURNAL OF IMMUNOLOGY

The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema

(2015) Cecilie Bo Hansen et al.   JOURNAL OF IMMUNOLOGY

Reincarnation of ancient links between coagulation and complement

(2015) E. M. Conway   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

MASP-1 of the complement system promotes clotting via prothrombin activation

(2015) Lorenz Jenny et al.   MOLECULAR IMMUNOLOGY

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Insights into the Initiating Complex of the Lectin Pathway of Complement Activation

(2015) Troels R. Kjaer et al.   STRUCTURE

MASP-1 Induced Clotting – The First Model of Prothrombin Activation by MASP-1

(2015) Lorenz Jenny et al.   PLoS One

Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4

(2014) Elham Asgari et al.   FASEB JOURNAL

Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway

(2014) Minoru Takahashi et al.   JOURNAL OF IMMUNOLOGY

Heterocomplex Formation between MBL/Ficolin/CL-11-Associated Serine Protease-1 and -3 and MBL/Ficolin/CL-11-Associated Protein-1

(2014) A. Rosbjerg et al.   JOURNAL OF IMMUNOLOGY

Serum MASP-1 in complex with MBL activates endothelial cells

(2014) Márton Megyeri et al.   MOLECULAR IMMUNOLOGY

Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation

(2014) Katalin Paréj et al.   MOLECULAR IMMUNOLOGY

MASP-1 Induces a Unique Cytokine Pattern in Endothelial Cells: A Novel Link between Complement System and Neutrophil Granulocytes

(2014) Péter K. Jani et al.   PLoS One

Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

(2014) Søren E. Degn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independentin vivo

(2013) M. M. Ruseva et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway

(2013) Márton Megyeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-Complexes of MASP-1 and MASP-2 Associated with the Soluble Pattern-Recognition Molecules Drive Lectin Pathway Activation in a Manner Inhibitable by MAp44

(2013) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway

(2013) M. Jacquet et al.   JOURNAL OF IMMUNOLOGY

Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid

(2013) R. M. Dunham et al.   JOURNAL OF IMMUNOLOGY

The control of the complement lectin pathway activation revisited: Both C1-inhibitor and antithrombin are likely physiological inhibitors, while α2-macroglobulin is not

(2013) Katalin Paréj et al.   MOLECULAR IMMUNOLOGY

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

(2013) Umakhanth Venkatraman Girija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Humoral Pattern Recognition and the Complement System

(2013) S. E. Degn et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Mannan-Binding Lectin Mediates Renal Ischemia/Reperfusion Injury Independent of Complement Activation

(2012) P. van der Pol et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endogenous and Natural Complement Inhibitor Attenuates Myocardial Injury and Arterial Thrombogenesis

(2012) Vasile I. Pavlov et al.   CIRCULATION

Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components

(2012) S. Thiel et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2

(2012) Dávid Héja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function

(2012) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

Effects of MASP-1 of the Complement System on Activation of Coagulation Factors and Plasma Clot Formation

(2012) Katharina Hess et al.   PLoS One

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease-Causing Mutations in Genes of the Complement System

(2011) Søren E. Degn et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway

(2011) D. Iwaki et al.   JOURNAL OF IMMUNOLOGY

Mannose-Binding Lectin-Associated Serine Protease-1 Is a Significant Contributor to Coagulation in a Murine Model of Occlusive Thrombosis

(2011) L. R. La Bonte et al.   JOURNAL OF IMMUNOLOGY

Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome

(2011) Caroline Rooryck et al.   NATURE GENETICS

Cleavage of Kininogen and Subsequent Bradykinin Release by the Complement Component: Mannose-Binding Lectin-Associated Serine Protease (MASP)-1

(2011) József Dobó et al.   PLoS One

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury

(2011) W. J. Schwaeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MASP1 Mutations in Patients with Facial, Umbilical, Coccygeal, and Auditory Findings of Carnevale, Malpuech, OSA, and Michels Syndromes

(2010) Asli Sirmaci et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma

(2010) Kusumam Joseph et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The bradykinin-forming cascade and its role in hereditary angioedema

(2010) Allen P. Kaplan et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation

(2010) Kazue Takahashi et al.   IMMUNOBIOLOGY

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Selective Inhibition of the Lectin Pathway of Complement with Phage Display Selected Peptides against Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 and -2: Significant Contribution of MASP-1 to Lectin Pathway Activation

(2010) A. Kocsis et al.   JOURNAL OF IMMUNOLOGY

Complement in atherosclerosis: friend or foe?

(2010) W. S. SPEIDL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Complement factor D, a novel serine protease

(2010) John E. Volanakis et al.   PROTEIN SCIENCE

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

C1 inhibitor, a multi-functional serine protease inhibitor

(2010) Fengxin Lu et al.   THROMBOSIS AND HAEMOSTASIS

Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot

(2009) Krishana C. Gulla et al.   IMMUNOLOGY

Identification of the C1q-binding Sites of Human C1r and C1s

(2009) Isabelle Bally et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role of Mannose-binding lectin-associated serine protease-1 in activation of the complement factor D

(2009) Minoru Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

(2009) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

MASP-1, a Promiscuous Complement Protease: Structure of Its Catalytic Region Reveals the Basis of Its Broad Specificity

(2009) J. Dobo et al.   JOURNAL OF IMMUNOLOGY

Analogous Interactions in Initiating Complexes of the Classical and Lectin Pathways of Complement

(2009) A. E. Phillips et al.   JOURNAL OF IMMUNOLOGY

Complement Protease MASP-1 Activates Human Endothelial Cells: PAR4 Activation Is a Link between Complement and Endothelial Function

(2009) M. Megyeri et al.   JOURNAL OF IMMUNOLOGY

Contact system activation in severe infectious diseases

(2009) Sonja Oehmcke et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen

(2008) Anders Krarup et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS