PCSK6-mediated corin activation is essential for normal blood pressure

PCSK9

(2014) Nabil G. Seidah et al.   CIRCULATION RESEARCH

Corin Mutations K317E and S472G from Preeclamptic Patients Alert Zymogen Activation and Cell Surface Targeting

(2014) Ningzheng Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G βγ -Independent Recruitment of G-Protein Coupled Receptor Kinase 2 Drives Tumor Necrosis Factor α–Induced Cardiac β-Adrenergic Receptor Dysfunction

(2013) Neelakantan T. Vasudevan et al.   CIRCULATION

Atrial Natriuretic Peptide Genetic Variant rs5065 and Risk for Cardiovascular Disease in the General Community

(2013) Valentina Cannone et al.   HYPERTENSION

Corin Mutation R539C from Hypertensive Patients Impairs Zymogen Activation and Generates an Inactive Alternative Ectodomain Fragment

(2013) Ningzheng Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions

(2013) Nabil G. Seidah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PCSK9 antibodies: a dividend of the genomics revolution

(2013) Michael H. Davidson   Nature Reviews Cardiology

Simple Genetics for a Complex Disease

(2013) J. C. Cohen et al.   SCIENCE

A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype

(2012) Anne-Marie Malfait et al.   ANNALS OF THE RHEUMATIC DISEASES

Heart Disease and Stroke Statistics—2013 Update

(2012) Alan S. Go et al.   CIRCULATION

Salt-Sensitive Hypertension and Cardiac Hypertrophy in Transgenic Mice Expressing a Corin Variant Identified in Blacks

(2012) Wei Wang et al.   HYPERTENSION

Corin Overexpression Improves Cardiac Function, Heart Failure, and Survival in Mice With Dilated Cardiomyopathy

(2012) Inna P. Gladysheva et al.   HYPERTENSION

Influence of rs5065 Atrial Natriuretic Peptide Gene Variant on Coronary Artery Disease

(2012) Emanuele Barbato et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice

(2012) Wei Wang et al.   KIDNEY INTERNATIONAL

Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy

(2012) Yujie Cui et al.   NATURE

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Process Matters

(2011) Daniel L. Dries   Circulation-Heart Failure

Ectodomain Shedding and Autocleavage of the Cardiac Membrane Protease Corin

(2011) Jingjing Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Corin Isoforms with Different Cytoplasmic Tails That Alter Cell Surface Targeting

(2011) Xiaofei Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease corin expression and activity in failing hearts

(2010) Shenghan Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Plasma Soluble Corin in Patients With Heart Failure

(2010) Ningzheng Dong et al.   Circulation-Heart Failure

Effect of Sialylated O-Glycans in Pro-Brain Natriuretic Peptide Stability

(2010) J. Jiang et al.   CLINICAL CHEMISTRY

A review of the role of atrial natriuretic peptide gene polymorphisms in hypertension and its sequelae

(2009) Amy I. Lynch et al.   CURRENT HYPERTENSION REPORTS

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Corin Variant Associated With Hypertension and Cardiac Hypertrophy Exhibits Impaired Zymogen Activation and Natriuretic Peptide Processing Activity

(2008) Wei Wang et al.   CIRCULATION RESEARCH

PCSK9: a convertase that coordinates LDL catabolism

(2008) Jay D. Horton et al.   JOURNAL OF LIPID RESEARCH

Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation

(2008) Denice M. Hodgson-Zingman et al.   NEW ENGLAND JOURNAL OF MEDICINE