The pleiotropic roles of leptin in metabolism, immunity, and cancer

Prevalence of residual inflammatory risk and associated clinical variables in patients with type 2 diabetes

(2020) Francesco Prattichizzo et al.   DIABETES OBESITY & METABOLISM

Eating behaviour in contrasting adiposity phenotypes: Monogenic obesity and congenital generalized lipodystrophy

(2020) José L. Santos et al.   Obesity Reviews

Autoantibody Production in Obesity: Is There Evidence for a Link Between Obesity and Autoimmunity?

(2020) Christina Tsigalou et al.   Current Obesity Reports

Peripheral leptin signaling persists in innate immune cells during diet‐induced obesity

(2020) Glaucia Souza‐Almeida et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Leptin alters energy intake and fat mass but not energy expenditure in lean subjects

(2020) Pavlina Chrysafi et al.   Nature Communications

Obesity and the risk of Multiple Sclerosis. The role of Leptin

(2020) Mariano Marrodan et al.   Annals of Clinical and Translational Neurology

Leptin resistance: underlying mechanisms and diagnosis

(2019) Olga Gruzdeva et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

The Role of Ghrelin in Regulating Synaptic Function and Plasticity of Feeding-Associated Circuits

(2019) Débora Serrenho et al.   Frontiers in Cellular Neuroscience

Obesity worsens central inflammation and disability in multiple sclerosis

(2019) Mario Stampanoni Bassi et al.   Multiple Sclerosis Journal

An immunometabolic pathomechanism for chronic obstructive pulmonary disease

(2019) Sara Bruzzaniti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity and Breast Cancer: Role of Leptin

(2019) Flora Sánchez-Jiménez et al.   Frontiers in Oncology

Serum leptin levels correlate negatively with the capacity of vitamin D to modulate the in vitro cytokines production by CD4+ T cells in asthmatic patients

(2019) Aleida S.O. Dias et al.   CLINICAL IMMUNOLOGY

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

(2019) Dayana B. Rivadeneira et al.   IMMUNITY

Leptin-Producing Oncolytic Virus Makes Tumor-Infiltrating T Cells Fit, Not Fat

(2019) Guido Kroemer et al.   IMMUNITY

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

(2019) Chunyan Zhang et al.   Cell Metabolism

Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease

(2019) Jörn F. Ziegler et al.   Nature Communications

Inflammageing and metaflammation: The yin and yang of type 2 diabetes

(2018) Francesco Prattichizzo et al.   AGEING RESEARCH REVIEWS

Efficacy of Metreleptin for Weight Loss in Overweight and Obese Adults with Low Leptin Levels

(2018) ALEX DEPAOLI et al.   DIABETES

Leptin Upregulates Peripheral CD4+CXCR5+ICOS+ T Cells via Increased IL-6 in Rheumatoid Arthritis Patients

(2018) Miaomiao Wang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

(2018) Ayano C. Kohlgruber et al.   NATURE IMMUNOLOGY

Leptin and ghrelin: Sewing metabolism onto neurodegeneration

(2018) Paola de Candia et al.   NEUROPHARMACOLOGY

The LepR-mediated leptin transport across brain barriers controls food reward

(2018) Alessandro Di Spiezio et al.   Molecular Metabolism

Leptin/Osteopontin Axis Regulated Type 2T Helper Cell Response in Allergic Rhinitis with Obesity

(2018) Qingxiang Zeng et al.   EBioMedicine

Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice

(2018) Rafi Mazor et al.   Science Translational Medicine

Fluorescent blood–brain barrier tracing shows intact leptin transport in obese mice

(2018) Luke Harrison et al.   INTERNATIONAL JOURNAL OF OBESITY

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

Leptin levels in patients with systemic lupus erythematosus inversely correlate with regulatory T cell frequency

(2017) X Wang et al.   LUPUS

Leptin in the interplay of inflammation, metabolism and immune system disorders

(2017) Vanessa Abella et al.   Nature Reviews Rheumatology

Toward a Wiring Diagram Understanding of Appetite Control

(2017) Mark L. Andermann et al.   NEURON

Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer

(2017) Mohamad Nidal Khabaz et al.   BMC Womens Health

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

Baseline adiponectin and leptin levels in predicting an increased risk of disease activity in rheumatoid arthritis: A meta-analysis and systematic review

(2016) Heng Cao et al.   AUTOIMMUNITY

Obesity and Cancer: The Oil that Feeds the Flame

(2016) Joan Font-Burgada et al.   Cell Metabolism

Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity

(2016) Valerie A. Gerriets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leptin Enhances TH2 and ILC2 Responses in Allergic Airway Disease

(2016) Handong Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation

(2016) Elaine V. Lourenço et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis

(2016) Laura Negrotto et al.   JAMA Neurology

A Report of Three Cases With Acquired Generalized Lipodystrophy With Distinct Autoimmune Conditions Treated With Metreleptin

(2015) Jasmin Lebastchi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Partial and Generalized Lipodystrophy: Comparison of Baseline Characteristics and Response to Metreleptin

(2015) Talia Diker-Cohen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin Receptor Signaling in T Cells Is Required for Th17 Differentiation

(2015) Bernardo S. Reis et al.   JOURNAL OF IMMUNOLOGY

Lymphoma in acquired generalized lipodystrophy

(2015) Rebecca J. Brown et al.   LEUKEMIA & LYMPHOMA

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis

(2015) Saroj Nepal et al.   Oncotarget

Obesity in autoimmune diseases: Not a passive bystander

(2014) Mathilde Versini et al.   AUTOIMMUNITY REVIEWS

Antagonizing leptin: current status and future directions

(2014) Lennart Zabeau et al.   BIOLOGICAL CHEMISTRY

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Deficient Leptin Signaling Ameliorates Systemic Lupus Erythematosus Lesions in MRL/Mp-Faslpr Mice

(2014) Y. Fujita et al.   JOURNAL OF IMMUNOLOGY

Leptin Induces a Proliferative Response in Breast Cancer Cells but Not in Normal Breast Cells

(2014) Virginie Dubois et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Leptin Enhances Availability of Apoptotic Cell-Derived Self-Antigen in Systemic Lupus Erythematosus

(2014) Gil Amarilyo et al.   PLoS One

Appearance and disappearance of the mRNA signature characteristic of Tregcells in visceral adipose tissue: Age, diet, and PPARγ effects

(2014) Daniela Cipolletta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Glucose impairs B-1 cell function in diabetes

(2013) K. Jennbacken et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Leptin promotes lupus T-cell autoimmunity

(2013) Gil Amarilyo et al.   CLINICAL IMMUNOLOGY

GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet

(2013) C. Clemmensen et al.   DIABETES

Metreleptin: First Global Approval

(2013) Ken Chou et al.   DRUGS

Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells

(2013) Pedro M.M. Moraes-Vieira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leptin antagonist ameliorates chronic colitis in IL-10−/− mice

(2013) Udai P. Singh et al.   IMMUNOBIOLOGY

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Metabolic fuelling of proper T cell functions

(2013) Giuseppe Matarese et al.   IMMUNOLOGY LETTERS

Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity

(2013) D. C. Saucillo et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Leptin-Induced ROR t Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus

(2013) Y. Yu et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cell proliferative potential is impaired in human autoimmune disease

(2013) Fortunata Carbone et al.   NATURE MEDICINE

Adipocytokine Profile, Cytokine Levels and Foxp3 Expression in Multiple Sclerosis: a Possible Link to Susceptibility and Clinical Course of Disease

(2013) Solaleh Emamgholipour et al.   PLoS One

Selective capacity of metreleptin administration to reconstitute CD4+T-cell number in females with acquired hypoleptinemia

(2013) Giuseppe Matarese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mature breast adipocytes promote breast cancer cell motility

(2012) Jennifer C. Carter et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Metabolic reprogramming and metabolic dependency in T cells

(2012) Ruoning Wang et al.   IMMUNOLOGICAL REVIEWS

Leptin-Induced mTOR Activation Defines a Specific Molecular and Transcriptional Signature Controlling CD4+ Effector T Cell Responses

(2012) C. Procaccini et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Fasting-Induced Hypoleptinemia Expands Functional Regulatory T Cells in Systemic Lupus Erythematosus

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Deconstruction of a neural circuit for hunger

(2012) Deniz Atasoy et al.   NATURE

Enhancement of hematopoiesis and lymphopoiesis in diet-induced obese mice

(2012) M. D. Trottier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Insulin and Leptin Increase Resistin and Inflammatory Cytokine Production from Human Mononuclear Cells

(2012) Panayoula C. Tsiotra et al.   Biomed Research International

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

(2011) H.-S. Moon et al.   DIABETES

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

(2011) Kathrin Eller et al.   DIABETES

Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells

(2011) B. B. Knight et al.   ENDOCRINE-RELATED CANCER

Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer

(2011) Laszlo Otvos et al.   EUROPEAN JOURNAL OF CANCER

Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet

(2011) Greeshma K Shetty et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Adipokines in Periaortic and Epicardial Adipose Tissue: Differential Expression and Relation to Atherosclerosis

(2011) Sofia G. Spiroglou et al.   Journal of Atherosclerosis and Thrombosis

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

Leptin as an immunomodulator

(2011) Claudio Procaccini et al.   MOLECULAR ASPECTS OF MEDICINE

What's new in our understanding of the role of adipokines in rheumatic diseases?

(2011) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis

(2011) Laszlo Otvos et al.   PEPTIDES

Review: Leptin gene expression in the placenta – Regulation of a key hormone in trophoblast proliferation and survival

(2011) J.L. Maymó et al.   PLACENTA

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

(2011) Jeffrey Deiuliis et al.   PLoS One

Leptin is an effective treatment for hypothalamic amenorrhea

(2011) S. H. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential effects of leptin on CD4 T cells in central and peripheral immune system are critically linked to the expression of leptin receptor

(2010) So Yong Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow

(2010) Cherry Kam Chun Lo et al.   Cellular & Molecular Immunology

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Leptin as a potential therapeutic target for breast cancer prevention and treatment

(2010) Amitbha Ray et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

Leptin Modulates the Survival of Autoreactive CD4+ T Cells through the Nutrient/Energy-Sensing Mammalian Target of Rapamycin Signaling Pathway

(2010) M. Galgani et al.   JOURNAL OF IMMUNOLOGY

Disruption of Leptin Receptor-STAT3 Signaling Enhances Leukotriene Production and Pulmonary Host Defense against Pneumococcal Pneumonia

(2010) P. Mancuso et al.   JOURNAL OF IMMUNOLOGY

A historical perspective on leptin

(2010) Douglas L Coleman   NATURE MEDICINE

Leptin and gastro-intestinal malignancies

(2010) J. M. Howard et al.   Obesity Reviews

Hyperleptinemia Is Required for the Development of Leptin Resistance

(2010) Zachary A. Knight et al.   PLoS One

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synovial/Serum leptin ratio in rheumatoid arthritis: the association with activity and erosion

(2010) Shereen M. Olama et al.   RHEUMATOLOGY INTERNATIONAL

Could Leptin Be Used to Treat Type 1 Diabetes?

(2010) C. Buettner   Science Translational Medicine

Circulating levels of leptin, adiposity and breast cancer risk

(2009) M-H Wu et al.   BRITISH JOURNAL OF CANCER

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

mTOR: taking cues from the immune microenvironment

(2009) Greg M. Delgoffe et al.   IMMUNOLOGY

Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation

(2009) C Rummel et al.   MOLECULAR PSYCHIATRY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation

(2008) A. Johnston et al.   BRITISH JOURNAL OF DERMATOLOGY

Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor

(2008) N. K. Saxena et al.   CANCER RESEARCH

Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-κB/p300 binding in human synovial fibroblasts

(2008) Kwok-Man Tong et al.   CELLULAR SIGNALLING

Leptin Predicts Diabetes but Not Cardiovascular Disease: Results from a large prospective study in an elderly population

(2008) P. Welsh et al.   DIABETES CARE

Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function

(2008) Eran Elinav et al.   HEPATOLOGY

Defects in Innate Immunity Predispose C57BL/6J-Leprdb/Leprdb Mice to Infection by Staphylococcus aureus

(2008) S. Park et al.   INFECTION AND IMMUNITY

Evolutionary origins of the obesity epidemic: natural selection of thrifty genes or genetic drift following predation release?

(2008) A M Prentice et al.   INTERNATIONAL JOURNAL OF OBESITY

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

(2008) J. D. Roth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral but not central leptin treatment increases numbers of circulating NK cells, granulocytes and specific monocyte subpopulations in non-endotoxaemic lean and obese LEW-rats

(2008) Philipp Haas et al.   REGULATORY PEPTIDES

Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNFα involvement

(2008) S. Rafail et al.   THROMBOSIS RESEARCH