Article
Immunology
Bozena Targonska-Stepniak, Krzysztof Grzechnik
Summary: This study aims to explore the relationships between adipokines (adiponectin, leptin) and metabolic parameters, as well as disease activity, in patients with chronic rheumatoid arthritis (RA). The results show that adipokines are indicators of metabolic disorders rather than inflammatory markers in patients with chronic RA, and high leptin levels may indicate poor prognostic factors, kidney, and cardiovascular complications. Adiponectin appears to be protective against metabolic disorders in chronic RA.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Nutrition & Dietetics
Vali Musazadeh, Shaghayegh Abbasi, Zeynab Kavyani, Amir Hossein Moridpour, Diba Safarzadeh, Zahra Moradi, Fatemeh Bahadori, Amir Hossein Faghfouri
Summary: This study found that curcumin supplementation can increase serum adiponectin and decrease leptin levels.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Endocrinology & Metabolism
Zongquan Zhao, Yihong Wu, Hao Zhang, Xiaohong Wang, Xiangfan Tian, Yijing Wang, Zhenjuan Qiu, Lingyan Zou, Zhenyuan Tang, Min Huang
Summary: In summary, women with endometriosis have higher levels of leptin and leptin/BMI ratio compared to controls, while they have lower levels of adiponectin. Additionally, patients with advanced-stage endometriosis exhibit significantly lower leptin levels, while adiponectin levels do not significantly differ between advanced and early-stage endometriosis patients.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Neurosciences
Cheng-Chun Liu, Qing-Hua Wang, Jia-Yan Xin, Yu-Hao Liu, Fan Zeng, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Gui-Hua Zeng, Yan-Jiang Wang, Yang Xiang, Yang Chen
Summary: This study investigated the associations between adiponectin, leptin, and resistin levels and Alzheimer's Disease (AD). The results showed that plasma adiponectin and leptin levels were associated with the presence, symptomatic severity, and diagnostic power of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Medicine, Research & Experimental
Annamaria Schaffer, Eszter Ducza, Nikolett Bodi, Maria Bagyanszki, Zita Szalai, Mohsen Mirdamadi, Tamara Barna, Kalman F. Szucs, Robert Gaspar
Summary: Leptin and adiponectin play a role in the relaxation of the pregnant uterus, but their efficacy decreases towards the end of gestation. The endometrial receptors have a fine-tuning role in uterine contractions, indicating the importance of these adipokines under altered adipokine level conditions.
Review
Oncology
Wenting Tie, Tao Ma, Zhigang Yi, Jia Liu, Yanhong Li, Jun Bai, Lijuan Li, Liansheng Zhang
Summary: Multiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Obesity increases the risk of MM and worsens outcomes for MM patients, and adipokines play a crucial role in the close association between MM and metabolic derangements. Epidemiologic studies have shown that the risk of MM is increased in obese individuals, and clinical evidence suggests a correlation between adipokines and MM. Adipokines are linked to various aspects of MM, including the behavior of MM cells, bone loss, disease progression, and drug resistance.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Review
Endocrinology & Metabolism
Jiangna Wang, Shiwei Liu, Yuxiang Zhao, Syed Shah Zaman Haider Naqvi, Ruixue Duan
Summary: This meta-analysis explores the relationship between adipokines levels (leptin, adiponectin, and chemerin) and the incidence of senile osteoporosis. The findings indicate that older individuals with lower levels of leptin and higher levels of chemerin are more likely to have senile osteoporosis. Additionally, there is a significant positive correlation between levels of leptin and adiponectin and body mass index.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Djedjiga Ait Eldjoudi, Alfonso Cordero Barreal, Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Yousof Farrag, Mariam Farrag, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, Jesus Pino, Oreste Gualillo
Summary: White adipose tissue is a specialized tissue involved in lipid synthesis and storage. It serves as an active organ that secretes hormones and cytokines called adipokines, with leptin being a key molecule. Leptin not only regulates energy balance and food intake, but also plays roles in reproduction, glucose metabolism, hematopoiesis, and immune system interactions. It is involved in innate and adaptive immunity and contributes to the pathogenesis of chronic inflammation and immune-related diseases like osteoarthritis and rheumatoid arthritis. This review summarizes recent findings on the involvement of leptin in immunity and inflammatory responses in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Haiyang Kou, Lei Huang, Meng Jin, Qi He, Rui Zhang, Jianbing Ma
Summary: The study evaluates the effectiveness and safety of curcumin in rheumatoid arthritis patients. It finds that curcumin supplementation is beneficial for the treatment of rheumatoid arthritis and can improve inflammation levels and clinical symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sung Soo Ahn, Taejun Yoon, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Summary: This study investigated the relationship between adipokines and clinical/laboratory findings in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). The study found that adipokines levels were associated with disease activity, with serum resistin potentially serving as a biomarker for reflecting disease activity.
Article
Medicine, Research & Experimental
Ali Taylan, Baris Akinci, Burak Toprak, Merih Birlik, Fatma Demet Arslan, Hasan Ekerbicer, Baris Gundogdu, Ayfer Colak, Bahar Engin
Summary: This study investigated the relationship between disease activity and adipocytokine levels in early rheumatoid arthritis patients, finding that those with high disease activity had higher BMI and leptin levels, which decreased after treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Hamed Varkaneh Kord, Grant M. Tinsley, Heitor O. Santos, Hamid Zand, Ali Nazary, Somaye Fatahi, Zeinab Mokhtari, Ammar Salehi-sahlabadi, Shing Cheng Tan, Jamal Rahmani, Mihnea-Alexandru Gaman, Brijesh Sathian, Amir Sadeghi, Behzad Hatami, Samira Soltanieh, Shahin Aghamiri, Hiba Bawadi, Azita Hekmatdoost
Summary: The study shows that fasting and energy-restricted diets can lead to significant reductions in serum leptin concentrations, with no significant effect on adiponectin concentrations. When energy intake is restricted to 50% or less of normal requirements, increases in adiponectin levels may be observed.
CLINICAL NUTRITION
(2021)
Review
Health Care Sciences & Services
Petros Dinas, Rikke Helene Moe, Carina I. Bostrom, Rena D. Kosti, George S. Kitas, George Metsios
Summary: Research evidence suggests that individual interventions of diet and physical activity effectively reduce inflammation in inflammatory joint diseases (IJD), but the combined use of these interventions is not well understood. This systematic review and meta-analysis focused on the effects and associations of combined diet and physical activity interventions in IJD, specifically rheumatoid arthritis (RA) and the spondyloarthropathies (SpA). The study found that the combination improved Health Assessment Questionnaire scores in RA patients, but unexpectedly increased erythrocyte sedimentation rate. No effects were found on C-reactive protein or weight of RA patients. Limited evidence was found to draw firm conclusions on the impact of combined diet and physical activity interventions on inflammatory load in IJDs.
Article
Public, Environmental & Occupational Health
Lingling Sun, Jiahao Zhu, Yuxiao Ling, Shuai Mi, Yasong Li, Tianle Wang, Yingjun Li
Summary: The meta-analyses of observational studies suggest that higher levels of physical activity are associated with a reduced risk of rheumatoid arthritis. However, genetic analyses indicate that physical activity may not necessarily help in preventing rheumatoid arthritis.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Gamze Serarslan, Oguzhan Ozcan, Ebru Okyay, Bahar Unlu, Mehmet Karadag
Summary: This study found that adiponectin and leptin may play a role in the pathogenesis of AA with scalp hair involvement. The results showed significantly higher serum levels of adiponectin and leptin in AA patients.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)