Nano-delivery systems focused on tumor microenvironment regulation and biomimetic strategies for treatment of breast cancer metastasis

Targeting metastatic cancer

(2021) Karuna Ganesh et al.   NATURE MEDICINE

A Bacteria-Inspired Morphology Genetic Biomedical Material: Self-Propelled Artificial Microbots for Metastatic Triple Negative Breast Cancer Treatment

(2021) Huayu Wu et al.   ACS Nano

Enhancing TNBC Chemo-immunotherapy via combination reprogramming tumor immune microenvironment with Immunogenic Cell Death

(2021) Shiyang Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model

(2020) Huan Xu et al.   BIOMATERIALS

Nanosponges of circulating tumor-derived exosomes for breast cancer metastasis inhibition

(2020) Hao Ye et al.   BIOMATERIALS

Engineering a Therapy‐Induced “Immunogenic Cancer Cell Death” Amplifier to Boost Systemic Tumor Elimination

(2020) Bei Li et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor-targeted delivery of silibinin and IPI-549 synergistically inhibit breast cancer by remodeling the microenvironment

(2020) Min Jiang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cancer cell membrane-coated biomimetic platform for targeted therapy of breast cancer in an orthotopic mouse model

(2020) Ling Han et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy

(2020) Ning Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Co‐Delivery of Paclitaxel and Interleukin‐12 Regulating Tumor Microenvironment for Cancer Immunochemotherapy

(2020) Qian Hu et al.   Advanced Healthcare Materials

Immune Checkpoint Inhibitor Rechallenge After Immune-Related Adverse Events in Patients With Cancer

(2020) Charles Dolladille et al.   JAMA Oncology

Targeted MIP-3β plasmid nanoparticles induce dendritic cell maturation and inhibit M2 macrophage polarisation to suppress cancer growth

(2020) Yihong He et al.   BIOMATERIALS

Delivery of thymoquinone through hyaluronic acid-decorated mixed Pluronic® nanoparticles to attenuate angiogenesis and metastasis of triple-negative breast cancer

(2020) Saurav Bhattacharya et al.   JOURNAL OF CONTROLLED RELEASE

Platelet membrane-cloaked paclitaxel-nanocrystals augment postoperative chemotherapeutical efficacy

(2020) Dong Mei et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

(2020) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition

(2020) Jialong Fan et al.   Acta Biomaterialia

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer

(2020) Flávia Castro et al.   BIOMATERIALS

A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer

(2020) Vikas Jain et al.   JOURNAL OF CONTROLLED RELEASE

Biomimetic theranostic strategy for anti-metastasis therapy of breast cancer via the macrophage membrane camouflaged superparticles

(2020) Binbin Liang et al.   Materials Science & Engineering C-Materials for Biological Applications

Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy

(2020) Ali Masjedi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

(2020) Lang Rao et al.   Nature Communications

Tumors and Their Microenvironment Dual‐Targeting Chemotherapy with Local Immune Adjuvant Therapy for Effective Antitumor Immunity against Breast Cancer

(2019) Caifeng Deng et al.   Advanced Science

FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation

(2019) Jun Yan et al.   Nature Communications

Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation

(2019) Xin Liang et al.   JOURNAL OF CONTROLLED RELEASE

Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy

(2019) Marta Truffi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer

(2019) Ping Zhou et al.   BIOMATERIALS

Human Cancer Cell Membrane-Coated Biomimetic Nanoparticles Reduce Fibroblast-Mediated Invasion and Metastasis and Induce T-Cells

(2019) Jiefu Jin et al.   ACS Applied Materials & Interfaces

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1α Downregulation

(2019) Tao Wang et al.   Frontiers in Oncology

Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition

(2019) Hao Ye et al.   BIOMATERIALS

Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA/CREB signaling pathway

(2019) Ali Masjedi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Immunostimulatory cytokine and doxorubicin co-loaded nanovesicles for cancer immunochemotherapy

(2019) Tingting Wu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages

(2019) Tian Zhang et al.   Advanced Healthcare Materials

Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam)

(2019) Fatemeh Farjadian et al.   International Journal of Nanomedicine

Tumor-Associated Fibroblast-Targeted Regulation and Deep Tumor Delivery of Chemotherapeutic Drugs with a Multifunctional Size-Switchable Nanoparticle

(2019) Xingli Cun et al.   ACS Applied Materials & Interfaces

Combretastatin A4 Nanoparticles Combined with Hypoxia-Sensitive Imiquimod: A New Paradigm for the Modulation of Host Immunological Responses during Cancer Treatment

(2019) Na Shen et al.   NANO LETTERS

Co-localized delivery of nanomedicine and nanovaccine augments the postoperative cancer immunotherapy by amplifying T-cell responses

(2019) Xiang Liu et al.   BIOMATERIALS

Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy

(2019) Hongwei Chen et al.   Nanomedicine

Biomimetic nanovesicles made from iPS cell-derived mesenchymal stem cells for targeted therapy of triple-negative breast cancer

(2019) Qingguo Zhao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Overcoming the Brain Barriers: From Immune Cells to Nanoparticles

(2019) Marc Charabati et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Programmable Ce6 Delivery via Cyclopamine Based Tumor Microenvironment Modulating Nano-System for Enhanced Photodynamic Therapy in Breast Cancer

(2019) Chan Feng et al.   Frontiers in Chemistry

Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy

(2018) Yuanyuan Liu et al.   Acta Biomaterialia

Traceable Bioinspired Nanoparticle for the Treatment of Metastatic Breast Cancer via NIR-Trigged Intracellular Delivery of Methylene Blue and Cisplatin

(2018) Yihui Zhai et al.   ADVANCED MATERIALS

Nanoscaled red blood cells facilitate breast cancer treatment by combining photothermal/photodynamic therapy and chemotherapy

(2018) Guoyun Wan et al.   BIOMATERIALS

Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy

(2018) Arunkumar Pitchaimani et al.   BIOMATERIALS

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

The breast tumor microenvironment: role in cancer development, progression and response to therapy

(2018) Suruchi Mittal et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple-negative breast cancer cells

(2018) Eric M. Bressler et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Amine-Functionalized Silica Nanoparticles with Drug and Gene Co-Delivery for Anti-Angiogenesis Therapy of Breast Cancer

(2018) Xiaojin Gong et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis

(2018) Xuejia Kang et al.   MOLECULAR PHARMACEUTICS

Cationic Polymeric Nanoparticle Delivering CCR2 siRNA to Inflammatory Monocytes for Tumor Microenvironment Modification and Cancer Therapy

(2018) Song Shen et al.   MOLECULAR PHARMACEUTICS

Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy

(2018) Yu Zhang et al.   NANO LETTERS

Synergistic tumor microenvironment targeting and blood–brain barrier penetration via a pH-responsive dual-ligand strategy for enhanced breast cancer and brain metastasis therapy

(2018) Man Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cancer stemness in bone marrow micrometastases of human breast cancer

(2018) Marissa C. Kuo et al.   SURGERY

Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis

(2018) Meysam Yousefi et al.   CELLULAR ONCOLOGY

Platelet-camouflaged nanococktail: Simultaneous inhibition of drug-resistant tumor growth and metastasis via a cancer cells and tumor vasculature dual-targeting strategy

(2018) Lijia Jing et al.   Theranostics

Current Challenges of Cancer Anti-angiogenic Therapy and the Promise of Nanotherapeutics

(2018) Ahmed M.E. Abdalla et al.   Theranostics

Co-administration of biocompatible self-assembled polylactic acid–hyaluronic acid block copolymer nanoparticles with tumor-penetrating peptide-iRGD for metastatic breast cancer therapy

(2018) Caifeng Deng et al.   Journal of Materials Chemistry B

Nanoparticle-Mediated Therapeutic Agent Delivery for Treating Metastatic Breast Cancer—Challenges and Opportunities

(2018) Yunfei Li et al.   Nanomaterials

Leukocyte-derived biomimetic nanoparticulate drug delivery systems for cancer therapy

(2018) Yukun Huang et al.   Acta Pharmaceutica Sinica B

Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment

(2018) Ruixiang Li et al.   Acta Pharmaceutica Sinica B

C–C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer

(2018) Hongjuan Zhao et al.   ACS Applied Materials & Interfaces

Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells

(2018) Yudong Song et al.   BIOMATERIALS

Immunogenic cell death in anticancer chemotherapy and its impact on clinical studies

(2018) Qiang Wang et al.   CANCER LETTERS

Tumor-associated macrophages in breast cancer: Innocent bystander or important player?

(2018) Si-Qi Qiu et al.   CANCER TREATMENT REVIEWS

The potential of biomimetic nanoparticles for tumor-targeted drug delivery

(2018) Bowen Li et al.   Nanomedicine

Modified Fe3O4 Magnetic Nanoparticle Delivery of CpG Inhibits Tumor Growth and Spontaneous Pulmonary Metastases to Enhance Immunotherapy

(2018) Xueyan Zhang et al.   Nanoscale Research Letters

Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway

(2018) Jianqin Lu et al.   ACS Nano

Cell-Membrane Immunotherapy Based on Natural Killer Cell Membrane Coated Nanoparticles for the Effective Inhibition of Primary and Abscopal Tumor Growth

(2018) Guanjun Deng et al.   ACS Nano

Roles of Myeloid-Derived Suppressor Cells in Cancer Metastasis: Immunosuppression and Beyond

(2018) Amin Pastaki Khoshbin et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment

(2018) J. M. Houthuijzen et al.   CANCER AND METASTASIS REVIEWS

Preparation and Characterization of Functionalized Graphene Oxide Carrier for siRNA Delivery

(2018) Jing Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response

(2018) Shulei Zhang et al.   CARBOHYDRATE POLYMERS

Erythrocyte-cancer hybrid membrane-camouflaged melanin nanoparticles for enhancing photothermal therapy efficacy in tumors

(2018) Qin Jiang et al.   BIOMATERIALS

Nanoparticles as new tools for inhibition of cancer angiogenesis

(2017) Nasser Hashemi Goradel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice

(2017) Farhad Jadidi-Niaragh et al.   JOURNAL OF CONTROLLED RELEASE

Exploiting tumor-associated dendritic cell heterogeneity for novel cancer therapies

(2017) Jiri Keirsse et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lymphoma Immunochemotherapy: Targeted Delivery of Doxorubicin via a Dual Functional Nanocarrier

(2017) Qianyu Zhai et al.   MOLECULAR PHARMACEUTICS

Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control

(2017) Zipeng Zhen et al.   NANO LETTERS

Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy

(2017) Xinyu He et al.   NANO LETTERS

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

(2017) N Cohen et al.   ONCOGENE

Doxorubicin Hydrochloride Loaded Zymosan-Polyethylenimine Biopolymeric Nanoparticles for Dual ‘Chemoimmunotherapeutic’ Intervention in Breast Cancer

(2017) Vivek K. Pawar et al.   PHARMACEUTICAL RESEARCH

Anti-angiogenic and anti-tumor effects of metronomic use of novel liposomal zoledronic acid depletes tumor-associated macrophages in triple negative breast cancer

(2017) Xin-Jun Cai et al.   Oncotarget

Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer

(2017) Elvira Donnarumma et al.   Oncotarget

Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models

(2017) Chunlei Guo et al.   Theranostics

Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes

(2017) Jinghan Su et al.   Theranostics

Nano-Hydroxyapatite-Derived Drug and Gene Co-Delivery System for Anti-Angiogenesis Therapy of Breast Cancer

(2017) Lina Zhao et al.   MEDICAL SCIENCE MONITOR

Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer

(2016) Haiqiang Cao et al.   ACS Nano

Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

(2016) Huiping Sun et al.   ADVANCED MATERIALS

Multi-stage inhibition in breast cancer metastasis by orally active triple conjugate, LHTD4 (low molecular weight heparin-taurocholate-tetrameric deoxycholate)

(2016) Farzana Alam et al.   BIOMATERIALS

Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles

(2016) Jiahe Li et al.   BIOMATERIALS

Nanoparticles for imaging and treatment of metastatic breast cancer

(2016) Qingxin Mu et al.   Expert Opinion on Drug Delivery

The role of heparins and nano-heparins as therapeutic tool in breast cancer

(2016) Nikos A. Afratis et al.   GLYCOCONJUGATE JOURNAL

Anti-tumor effect via passive anti-angiogenesis of PEGylated liposomes encapsulating doxorubicin in drug resistant tumors

(2016) Golam Kibria et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer

(2016) Mengmeng Niu et al.   MOLECULAR PHARMACEUTICS

Highly Integrated Nano-Platform for Breaking the Barrier between Chemotherapy and Immunotherapy

(2016) Di-Wei Zheng et al.   NANO LETTERS

Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules

(2016) Zoi Piperigkou et al.   TOXICOLOGY LETTERS

Dendritic Cells and Cancer Immunity

(2016) Alycia Gardner et al.   TRENDS IN IMMUNOLOGY

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

(2015) Tianjiao Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

(2015) Shaobo Ruan et al.   BIOMATERIALS

Development of nanotheranostics against metastatic breast cancer — A focus on the biology & mechanistic approaches

(2015) Anuradha Subramanian et al.   BIOTECHNOLOGY ADVANCES

Modulating mammary tumor growth, metastasis and immunosuppression by siRNA-induced MIF reduction in tumor microenvironment

(2015) M Zhang et al.   CANCER GENE THERAPY

Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer

(2015) Z. Ao et al.   CANCER RESEARCH

Captopril-polyethyleneimine conjugate modified gold nanoparticles for co-delivery of drug and gene in anti-angiogenesis breast cancer therapy

(2015) Manhong Li et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Macrophage mediated biomimetic delivery system for the treatment of lung metastasis of breast cancer

(2015) Jijun Fu et al.   JOURNAL OF CONTROLLED RELEASE

Multifunctional Albumin–MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response

(2014) Preethy Prasad et al.   ACS Nano

Nanoparticulate carriers: an emerging tool for breast cancer therapy

(2014) Priyanka Tharkar et al.   JOURNAL OF DRUG TARGETING

Hydrazinocurcumin Encapsuled Nanoparticles “Re-Educate” Tumor-Associated Macrophages and Exhibit Anti-Tumor Effects on Breast Cancer Following STAT3 Suppression

(2013) Xiwen Zhang et al.   PLoS One

Perturbation of the heparin/heparin-sulfate interactome of human breast cancer cells modulates pro-tumourigenic effects associated with PI3K/Akt and MAPK/ERK signalling

(2013) Yunliang Chen et al.   THROMBOSIS AND HAEMOSTASIS

A specific peptide ligand-modified lipid nanoparticle carrier for the inhibition of tumor metastasis growth

(2012) Zhaohui Wang et al.   BIOMATERIALS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanoparticle delivery for metastatic breast cancer

(2012) Stephen R. Grobmyer et al.   Nanomedicine-Nanotechnology Biology and Medicine

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

(2011) Qing Chen et al.   CANCER CELL

Natural Killer Cell Responses to Viral Infection

(2011) Joshua D. Brandstadter et al.   Journal of Innate Immunity

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Regulatory T cells and breast cancer: implications for immunopathogenesis

(2010) Maria Angelica Ehara Watanabe et al.   CANCER AND METASTASIS REVIEWS