Article
Chemistry, Multidisciplinary
Wanwan Pan, Weijian Chen, Yuanzeng Min, Jing Wang, Zhenye Yang, Tian Xu, Fazhi Yu, Guodong Shen, Yuan Hu, Xiaopeng Ma
Summary: ICG-loaded poly(ethylene glycol) (PEG)-modified BPNS (ICG@BPNS-PEG) nanocomposites have been successfully constructed with improved tumor-targeting capacity and guidance for photothermal therapy, exhibiting good photostability and enhanced photothermal conversion ability. The nanocomposites show lower cytotoxicity and good cellular compatibility, as well as satisfactory photothermal therapeutic effects, indicating substantial potential in breast cancer therapy.
Article
Engineering, Biomedical
Jing Liu, Xixi Ai, Horacio Cabral, Jinlu Liu, Yuan Huang, Peng Mi
Summary: The development of hypoxia-activatable polymeric micelles for tumor-targeted therapy is effective for eradicating advanced breast cancer by triggering synergistic cytotoxicity and immunogenic cell death. These micelles efficiently deliver drugs and photosensitizers to cancer cells, and have the potential to significantly suppress tumor recurrence and metastasis.
Article
Medicine, Research & Experimental
Malcolm Lim, Nicholas L. Fletcher, Jodi M. Saunus, Amy E. McCart Reed, Haarika Chittoory, Peter T. Simpson, Kristofer J. Thurecht, Sunil R. Lakhani
Summary: This study demonstrates the potential of a HER3-targeted hyperbranched polymer (HBP) nanomedicine for the treatment of breast cancer brain metastases. The HBP carrier can selectively deliver and release the chemotherapy drug doxorubicin (DOX) in a pH-responsive manner. The nanomedicine shows effective drug release and cytotoxicity against breast cancer cells, and in a mouse model, it inhibits tumor proliferation, reduces tumor size, and prolongs overall survival. Furthermore, the nanomedicine exhibits lower toxicity compared to free DOX.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Rita Moreira, Andreia Granja, Marina Pinheiro, Salette Reis
Summary: Breast cancer was responsible for a high mortality rate in 2018, and nanomedicine has opened up new possibilities for treatment, particularly in the use of nanoparticles. However, further evaluations are needed to fully understand the efficacy and safety profile of these treatments in clinical settings.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, Research & Experimental
Mackenzie A. A. Scully, Dana E. E. Wilkins, Megan N. N. Dang, Elise C. C. Hoover, Sara B. B. Aboeleneen, Emily S. S. Day
Summary: Overexpression of B-cell lymphoma 2 (Bcl-2) is linked to poor prognosis in triple-negative breast cancer (TNBC), but current Bcl-2 inhibitors have limited success against solid tumors. In this study, Bcl-2 inhibitor ABT-737 was loaded into poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with cancer cell membranes, which increased targeting of TNBC cells and improved accumulation in tumors compared to regular PLGA nanoparticles. The cancer cell membrane-wrapped PLGA nanoparticles induced higher levels of apoptosis in TNBC cells in vitro and showed increased anticancer effects in a metastasis model. The specific targeting provided by the TNBC cell membrane coating also reduced off-target adverse effects. Further development of drug-loaded biomimetic nanoparticles may be a promising approach for treating TNBC.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Zhaofeng Li, Peixin Liu, Wei Chen, Xueying Liu, Fan Tong, Junhui Sun, Yang Zhou, Ting Lei, Wenqin Yang, Dong Ma, Huile Gao, Yi Qin
Summary: This study found that icaritin had a strong synergistic effect with the epigenetic drug JQ1, which could help overcome drug resistance. To improve tumor-targeted delivery, a hypoxia-cleavable, RGD peptide-modified nanoparticle called ARNP was developed. In vitro and in vivo experiments showed that ARNP effectively suppressed primary tumor, bone metastasis, and pulmonary metastasis.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Tom A. Lemaitre, Andrew R. Burgoyne, Maarten Ooms, Tatjana N. Parac-Vogt, Thomas Cardinaels
Summary: This review discusses the incorporation of therapeutic radionuclides into inorganic nanoconstructs as carriers for cancer treatment. Different types of nanomaterials and methods of incorporating radionuclides, and their impact on stability and in vitro and in vivo performances, are discussed.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Z. Fereshteh, M. N. Dang, C. Wenck, E. S. Day, J. H. Slater
Summary: This study investigated the efficacy of inhibiting cancer cell binding to human lung microvascular endothelial cells (HMVEC-Ls) via antibody blocking of E-selectin using antibody-functionalized gold nanoshells (NS). The results demonstrated that E-selectin-targeted NS reduced the binding of MDA-MB-231 cancer cells to HMVEC-Ls by up to 41%, suggesting the potential of these conjugates in inhibiting cancer cell extravasation during metastasis.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhengqing Guo, Hui He, Yi Zhang, Jiaming Rao, Tao Yang, Ting Li, Lu Wang, Mengke Shi, Mengya Wang, Shihong Qiu, Xue Song, Hengte Ke, Huabing Chen
Summary: This study demonstrates the use of self-assembled micellar nanoarchitecture for potent phototherapy against triple-negative breast cancer, showing efficient suppression against primary, metastatic, and recurrent TNBC through tunable photoconversion and cytoplasmic translocation.
ADVANCED MATERIALS
(2021)
Article
Cell Biology
Huimin Shao, Pegah Varamini
Summary: This review discusses promising nanotechnologies for targeted delivery of therapeutics to improve the treatment of breast cancer bone metastasis. Understanding these new therapeutic approaches may improve the survival and quality of life of patients with bone metastasis from breast cancer.
Review
Oncology
Siyi Xiong, Xuanni Tan, Xiujuan Wu, Andi Wan, Guozhi Zhang, Cheng Wang, Yan Liang, Yi Zhang
Summary: Breast cancer is the most commonly diagnosed cancer worldwide, and brain metastasis of breast cancer is a major cause of mortality with no effective treatment. Understanding the cellular and molecular mechanisms of brain metastasis is crucial for developing new therapeutic strategies. This review focuses on the molecular subtype of breast cancer, brain microenvironment, exosomes, miRNAs/lncRNAs, and genetic background in brain metastasis. It also discusses novel approaches to bypass the blood-brain barrier and blood-tumor barrier, as well as the potential application of immunotherapies and genetic editing techniques in treating brain metastasis.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Poonam Banthia, Lokesh Gambhir, Asha Sharma, Dhiraj Daga, Neha Kapoor, Rishabh Chaudhary, Gaurav Sharma
Summary: This review discusses the breakthrough of nanotechnology in targeted drug delivery for breast cancer treatment. Nanomedicines using nanoenabled carriers offer advantages like targeted delivery, stability, biocompatibility, and enhanced efficacy. Various nanoassemblies have revolutionized targeted therapeutic delivery by improving drug solubility, reducing dose and toxicity. However, challenges such as identifying appropriate biomarkers, understanding biological processes, ensuring batch uniformity and nanomaterial toxicity and stability still exist.
Review
Biotechnology & Applied Microbiology
Jingjing Wang, Jie Tan, Bian Wu, Ruolin Wu, Yanmei Han, Chenyang Wang, Zairong Gao, Dawei Jiang, Xiaotian Xia
Summary: This review provides a comprehensive overview of the application of nanomedicine in the treatment of anaplastic thyroid cancer (ATC). It summarizes various therapeutic methods, including chemotherapy, differentiation therapy, radioiodine therapy, gene therapy, targeted therapy, photothermal therapy, and combination therapy. The review also discusses the future challenges and opportunities for nanomedicine in ATC treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Mahmood Rasool, Arif Malik, Sulayman Waquar, Mahwish Arooj, Sara Zahid, Muhammad Asif, Sumaira Shaheen, Abrar Hussain, Hamid Ullah, Siew Hua Gan
Summary: Nanomedicines have been applied as alternative treatments for anticancer agents, utilizing their small size to achieve specific site targeting and reduce toxic side effects. They also offer cost savings by requiring minute amounts of drugs. Nanotechnology has been effectively utilized in the preparation of these drugs, and large nanomaterials have been used to develop novel cancer cures.
Review
Pharmacology & Pharmacy
Wenqi Yu, Chuan Hu, Huile Gao
Summary: Breast cancer is the most common tumor in women and its metastasis increases malignancy and mortality. Nanomedicines have shown great potential in treating cancer metastasis by specifically designed functions at different stages of the process, providing new solutions.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Yunfei Li, Dali Qian, Hsuan-Pei Lin, Jie Xie, Ping Yang, Drew Maddy, Yajuan Xiao, Xuefei Huang, Zhishan Wang, Chengfeng Yang
Summary: The study developed a novel ultrasmall Pt(II) dot that displayed superior DNA damage capability and significantly reduced the CSC-like properties of TNBC cells, as well as targeted circulating tumor cells in vivo to suppress breast cancer metastasis. The ultrasmall Pt(II) dots represent a promising therapeutic agent for reducing cancer metastasis through metal-based nanomedicines.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Brock Humphries, Zhishan Wang, Chengfeng Yang
Summary: Recent advances in understanding breast cancer have highlighted the key role of CSCs in progression and recurrence, with miRNAs playing a crucial role in regulating CSC characteristics. MiRNAs have the potential to serve as biomarkers and clinical therapeutics for breast cancer by targeting signaling pathways associated with CSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang
Summary: m(6)A RNA methylation is a prevalent internal modification in mammalian mRNAs, dysregulation of which is frequently observed in pathological conditions, particularly in cancer. Recent studies have shown that oncogenic signaling pathways in cancer are modulated by m(6)A modifications in target mRNAs and noncoding RNA transcripts.
Article
Engineering, Biomedical
Brock A. Humphries, Mitra Aliabouzar, Carole Quesada, Avinash Bevoor, Kenneth K. Y. Ho, Alex Farfel, Johanna M. Buschhaus, Shrila Rajendran, Mario L. Fabiilli, Gary D. Luker
Summary: Cancer cells continuously sense and respond to mechanical cues from the extracellular matrix (ECM), which can alter intracellular signaling and promote cancer progression. This study used a novel composite hydrogel technology to investigate the effects of local mechanical properties on breast cancer cell signaling. The findings demonstrate that changes in ECM compaction regulate key signaling pathways in breast cancer cells and support further applications of this technology in analyzing spatial and temporal effects on cell signaling and cancer biology.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Toxicology
Zhishan Wang, Mohammad Burhan Uddin, Jie Xie, Hua Tao, Patti C. Zeidler-Erdely, Kazuya Kondo, Chengfeng Yang
Summary: This study reveals that chronic exposure to hexavalent chromium can alter cellular epitranscriptome by increasing m(6)A RNA modification through upregulation of the RNA methyltransferase METTL3 expression, which plays an important role in Cr(VI)-induced cell transformation, CSC-like property, and tumorigenesis.
TOXICOLOGICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Harrison L. Hiraki, Daniel L. Matera, William Y. Wang, Eashan S. Prabhu, Zane Zhang, Firaol Midekssa, Anna E. Argento, Johanna M. Buschhaus, Brock A. Humphries, Gary D. Luker, Abdon Pena-Francesch, Brendon M. Baker
Summary: The peritumoral stroma is a complex tissue that influences the migration mode of transformed epithelial cells during metastatic spread. Understanding the role of cues from the stromal microenvironment in regulating migration mode has prognostic and therapeutic value.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Chengfeng Yang, Zhishan Wang
Summary: Metals are common toxic environmental pollutants that cause severe adverse health effects and even cancer. The emerging field of epitranscriptomic study provides new insights into the mechanisms of metal toxicity and carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Tanner H. Robison, Manisha Solipuram, Kevin Heist, Ghoncheh Amouzandeh, Winston Y. Lee, Brock A. Humphries, Johanna M. Buschhaus, Avinash Bevoor, Anne Zhang, Kathryn E. Luker, Kristen Pettit, Moshe Talpaz, Dariya Malyarenko, Thomas L. Chenevert, Brian D. Ross, Gary D. Luker
Summary: Histopathology has limitations in assessing bone marrow (BM) in hematologic malignancies. MRI can overcome these limitations and provide dynamic information about BM changes. MRI can detect the effects of treatment and monitor disease progression in a short period of time.
Article
Biochemistry & Molecular Biology
Osama Sweef, Chengfeng Yang, Zhishan Wang
Summary: Chronic exposure to hexavalent chromium is associated with lung cancer, and the lncRNA and miRNA play critical roles in the occurrence and progression of lung cancer.
Article
Oncology
Johanna M. Buschhaus, Shrila Rajendran, Siyi Chen, Bryan L. Wharram, Avinash S. Bevoor, Alyssa C. Cutter, Brock A. Humphries, Tanner H. Robison, Alex P. Farfel, Gary D. Luker
Summary: Cancer cells adapt their energy metabolism to resist therapy through metabolic plasticity. In a coculture model of ER+ breast cancer and MSCs, it was found that coculturing with MSCs increased oxidative phosphorylation and ATP levels, leading to resistance to standard therapies. This resistance was overcome by inhibiting MCT1/4 and combining it with fulvestrant, suggesting metabolic interventions as potential strategies to overcome resistance in ER+ breast cancer.
MOLECULAR CANCER RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Lei Yang, Liming Gong, Ping Wang, Xinghui Zhao, Feng Zhao, Zhijie Zhang, Yunfei Li, Wei Huang
Summary: mRNA technology utilizes messenger RNA transcribed from DNA as a template to treat diseases. Lipid nanoparticles (LNPs) show potential in clinical translation as non-viral delivery tools and are particularly important for delivering nucleic acids into cells in current mRNA regimens. The latest research progress of LNPs is mainly focused on the treatment of other diseases such as oncological, cardiovascular, and infectious diseases.
Article
Pharmacology & Pharmacy
Yingpeng Li, Liang Liu, Hongtao Shang, Xuchen Feng, Ni Fan, Jingyu Wang, Yuqi Wu, Yatong Chen, Xinhong Chu, Min Zhong, Yujiao Sun, Hui Fu, Wei Huang, Yunfei Li
Summary: This study reports a chitosan-based hyaluronic acid nanoparticle that self-assembles and effectively treats triple-negative breast cancer in vivo. The nanoparticle targets tumor cells and improves the bioavailability of the drug, offering a new strategy for the treatment of triple-negative breast cancer.
Article
Multidisciplinary Sciences
Brock A. Humphries, Anne Zhang, Johanna M. Buschhaus, Avinash Bevoor, Alex Farfel, Shrila Rajendran, Alyssa C. Cutter, Gary D. Luker
Summary: Reactive oxygen species (ROS) produced by mitochondria can affect intracellular ROS levels in cancer cells. Increasing ROS levels through promoting mitochondrial fission inhibits cell migration in triple negative breast cancer (TNBC).
Article
Environmental Sciences
Zhishan Wang, Zulong Liu, Po-Shun Wang, Hsuan-Pei Lin, Matthew Rea, Kazuya Kondo, Chengfeng Yang
Summary: Hexavalent chromium is a common environmental pollutant that can cause lung cancer and other types of cancer in humans. This study investigates the impact of hexavalent chromium's epigenetic toxic effect on its genotoxic effect and reveals the importance of the DNA damage repair protein MGMT in the process of hexavalent chromium exposure.
ENVIRONMENTAL POLLUTION
(2024)
