Article
Engineering, Environmental
Xuemei Zeng, Pengjie Li, Shuangqian Yan, Bi-Feng Liu
Summary: The combination of nanomaterials and nanotechnologies in nanomedicine has attracted intensive attention and made significant advances in tumor treatment. However, the passive nature of currently used nanomaterial carriers limits their therapeutic efficiency. An active nanomaterial carrier with tumor-taxis-like behavior holds the potential to further improve tumor targeting and therapeutic efficiency. This study demonstrates a tumor microenvironment responsive disassemblable approach using tumor-targeted Escherichia coli bacteria linked with degradable zeolitic imidazolate framework-8 (ZIF-8) through disulfide bond-contained polymers. The approach shows promise in delivering multiple drugs into deep tumor tissue and improving tumor inhibition efficacy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiyou Du, Xiaoye Yang, Yu Zhang, Shan Gao, Shangui Liu, Jianbo Ji, Guangxi Zhai
Summary: In this study, a new nanosheet D-1/GH was developed to overcome the challenges of skin penetration and tumor infiltration in melanoma treatment. D-1/GH can penetrate the skin through heparin-mediated hydration of the stratum corneum and be transported to the tumor site through blood and lymphatic vessels. D-1/GH can induce immunogenic cell death, recruit immune cells, and boost immune response. Furthermore, D-1/GH can reverse the immunosuppressive tumor microenvironment and suppress tumor metastasis.
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Article
Oncology
Mengdan Xu, Shenglong Li
Summary: This comprehensive review provides an overview of current research on nano-drug delivery systems for melanoma treatment, with a focus on liposomes, polymeric nanoparticles, and inorganic nanoparticles. It discusses the potential of these nanoparticles for targeted drug delivery, as well as their ability to enhance the efficacy of conventional drugs while minimizing toxicity. Furthermore, this review emphasizes the significance of interdisciplinary collaboration in advancing the development of nanomedicines.
Article
Oncology
Miok Kim, Yong Ki Min, Jinho Jang, Hyejin Park, Semin Lee, Chang Hoon Lee
Summary: This study reveals the distinct immune modulation effects of CD73 inhibition compared to PD-1 blockade, suggesting that AB680 may serve as a novel anticancer immunotherapy for CRC with potential synergistic effects when combined with PD-1 blockers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Yongzhuo Huang
Summary: There is a close relationship between cancer metabolism and immunity. Targeting cancer metabolism shows promise as a therapeutic approach for cancer immunotherapy. The Warburg effect, characterized by abnormal glucose metabolism, can modify cancer cells and create a suppressive immune microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Beining Yang, Fanze Meng, Jihao Zhang, Kerun Chen, Siyu Meng, Kaiyong Cai, Yanli Zhao, Liangliang Dai
Summary: The tumor microenvironment (TME) plays a crucial role in tumor occurrence, development, and metastasis. Reprogramming TME is a potential therapeutic target for effective tumor damage. Nanobiomaterials have been extensively integrated into the construction of engineered drug delivery nanosystems for TME normalization therapy.
Article
Nanoscience & Nanotechnology
Zhengjie Meng, Hao Wang, Xue Fang, Zhangya Liu, Zheng Yang, Jiahui Yong, Qingqing Yang, Yunhao Bai, Hao Ren, Hao Xu, Xueming Li
Summary: The study demonstrated that utilizing P-selectin as a target for drug nanocrystals to tumors can enhance drug accumulation and anti-tumor efficacy, while maintaining a good safety profile for cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Wan Su Yun, Man Kyu Shim, Seungho Lim, Sukyung Song, Jinseong Kim, Suah Yang, Hee Sook Hwang, Mi Ra Kim, Hong Yeol Yoon, Dong-Kwon Lim, In-Cheol Sun, Kwangmeyung Kim
Summary: In this study, a promising approach of using mesenchymal stem cells (MSCs) for the deep tumor delivery of gold nanorods (AuNRs) has been demonstrated. The AuNRs are modified and chemically conjugated to the MSCs, allowing deep tissue penetration and enhanced photothermal effect against colon tumor growth. This provides a potential method for effective photothermal therapy.
Review
Medicine, Research & Experimental
Wenpan Li, Nicholas Little, Jonghan Park, Cole Alexander Foster, Jiawei Chen, Jianqin Lu
Summary: Nanoparticle drug delivery systems have improved antitumor efficacy, but achieving satisfactory distribution and penetration inside solid tumors, especially in stromal fibrous tumors, remains challenging. Tumor-associated fibroblasts reduce the drug delivery efficiency of nanoparticles, making them attractive targets for enhancing tumor delivery efficiency and efficacy of anticancer agents. Opportunities to summarize the underlying mechanisms of TAFs on obstructing nanoparticle-mediated drug delivery into tumors and discuss nanotherapeutic approaches for effectively targeting TAFs have been extensively explored.
MOLECULAR PHARMACEUTICS
(2021)
Article
Materials Science, Multidisciplinary
Mingming Song, Bin Zhu, Shuang Qiu, Jiameng Tian, Jianning Li, Daling Chen, Chang Liu
Summary: IL4RPep-1-targeting peptide nanoparticles efficiently deliver afuresertib and celecoxib to melanoma cells, promoting cell apoptosis and immune response, while reducing adverse reactions.
APPLIED MATERIALS TODAY
(2023)
Review
Oncology
Raisa A. Glabman, Peter L. Choyke, Noriko Sato
Summary: This review summarizes the current research on cancer-associated fibroblasts (CAFs), highlights major challenges, and discusses future opportunities for improving CAF biology and targeting.
Review
Nanoscience & Nanotechnology
Yongjia Huang, Tingting Wang, Qunyou Tan, Dan He, Mingjun Wu, Jingchuan Fan, Jie Yang, Cailing Zhong, Kailing Li, Jingqing Zhang
Summary: The article discusses the challenges of delivering therapeutic agents specifically to dysfunctional mitochondria in tumor progression and presents a variety of pathways to achieve smart stimuli-responsive and mitochondria-targeted drug delivery systems. These systems not only target the mitochondria with precision but also respond to internal and external stimuli to increase efficacy and reduce side effects, showing promise as a potential precision medicine for cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Donghyun Lee, Soonmin Kwon, Seok-Young Jang, Eunyoung Park, Yeeun Lee, Heebeom Koo
Summary: Photodynamic therapy (PDT) faces challenges in tumor treatment, including drug delivery, light delivery, and tumor microenvironment. Nanoparticles have shown promising potential to overcome these challenges as drug carriers. Various approaches such as physicochemical optimization, ligand modification, and stimuli-responsive release have been explored in experiments, but more research is needed.
BIOACTIVE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Lichun Cheng, Jiankun Yu, Tangna Hao, Wenshuo Wang, Minjie Wei, Guiru Li
Summary: This review article provides an extensive survey of recent progress in cancer immunotherapy strategies utilizing polymer micelles. These strategies include responsive and remodeling approaches to the tumor microenvironment, modulation of immunosuppressive cells, enhancement of immune checkpoint inhibitors, utilization of cancer vaccine platforms, manipulation of antigen presentation, manipulation of engineered T cells, and targeting other components of the tumor microenvironment. Polymer micelles demonstrate excellent prospects in tumor immunotherapy by effectively addressing the challenges associated with conventional cancer immunotherapies.
Article
Nanoscience & Nanotechnology
Miao Deng, Rong Guo, Shuya Zang, Jingdong Rao, Mengmeng Li, Xian Tang, Chunyu Xia, Man Li, Zhirong Zhang, Qin He
Summary: The study introduced a pH-responsive self-aggregated nanoparticle for the co-delivery of chemotherapy drugs and signaling pathway inhibitors, which could quickly aggregate in the tumor microenvironment and enhance tumor retention. The combination of chemotherapy and immunotherapy using this strategy showed significant efficacy in melanoma treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Qianwen Yu, Xian Tang, Wei Zhao, Yue Qiu, Jiao He, Dandan Wan, Jianping Li, Xuhui Wang, Xuan He, Yayuan Liu, Man Li, Zhirong Zhang, Qin He
Summary: The combination of mild hyperthermia and immune checkpoint blockade treatment effectively suppressed tumor growth and metastasis; size-adjustable nanoparticles have great potential in improving cancer treatment outcomes.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Zhengze Lu, Yang Long, Yashi Wang, Xuhui Wang, Chunyu Xia, Man Li, Zhirong Zhang, Qin He
Summary: The study confirmed that the PBA-LMWH-TOS NP nanoparticles can effectively inhibit pancreatic tumors and metastases, and improve the immune microenvironment. Additionally, LMWH can interfere with Pselectin/PSGL-1 binding to prevent the recruitment of MDSCs to pancreatic tumor tissues.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Xian Tang, Qinglin Sheng, Chaoqun Xu, Man Li, Jingdong Rao, Xuhui Wang, Yang Long, Yuan Tao, Xuan He, Zhirong Zhang, Qin He
Summary: A tumor-targeting and rapid gene release nano-courier based on phenylboronic acid (PBA) was constructed to enhance photothermal therapy by delivering PD-L1 siRNA. The nano-courier could effectively penetrate and be taken up by tumors with overexpressed sialic acid residues, leading to efficient PD-L1 silencing and triggering systemic antitumor immune responses, ultimately resulting in the complete ablation of orthotopic tumors and suppression of metastasis and recurrence.
Article
Nanoscience & Nanotechnology
Wei Zhao, Ting Li, Yang Long, Rong Guo, Qinglin Sheng, Zhengze Lu, Man Li, Jiaxin Li, Shuya Zang, Zhirong Zhang, Qin He
Summary: This study developed a photothermal therapy strategy using activated platelets as bridges to enhance drug delivery efficacy for inhibiting the growth of primary tumors and metastasis in metastatic cancer treatment. By utilizing mitochondrial targeting, platelet targeting, and metastasis-EPR effects, the constructed nanoplatform effectively improved drug accumulation and inhibited tumor growth and metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Mengmeng Li, Rong Guo, Jiaojie Wei, Miao Deng, Jiaxin Li, Yuan Tao, Man Li, Qin He
Summary: The utilization of a polydopamine-based core-shell nanoplatform loaded with CpG ODNs can enhance the efficacy of photothermal therapy against melanoma by inducing robust photothermal ablation and antitumor immune responses. This approach effectively promotes DC maturation and achieves a synergistic treatment effect with immunotherapy, overcoming the immune insufficiency induced by photothermal therapy alone.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Rong Guo, Miao Deng, Xuan He, Mengmeng Li, Jiaxin Li, Penghui He, Houqin Liu, Man Li, Zhirong Zhang, Qin He
Summary: Tumor metastasis is a major cause of cancer patient mortality and poses challenges in clinical cancer treatment. Nanoparticles hitchhiking on activated platelets have shown excellent targeting ability for primary tumor, circulating tumor cells (CTCs), and distant metastasis. However, the activated tumor-homing platelets release TGF-beta, promoting tumor metastasis and immunosuppressive microenvironment formation. A fucoidan-functionalized micelle was developed in this study, which effectively adhered to activated platelets and exhibited anti-tumor and anti-metastasis efficacy in a spontaneous metastasis model. The fucoidan-functionalized micelle also inhibited TGF-beta expression and reversed the immunosuppressive microenvironment.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Engineering, Biomedical
Kebai Ren, Jiao He, Yue Qiu, Zhuping Xu, Xuhui Wang, Jiaxin Li, Shuya Zang, Yiliang Yang, Jiaxin Li, Yang Long, Zhirong Zhang, Man Li, Qin He
Summary: This study aimed to prevent postoperative recurrence and metastasis of breast cancer using a Trojan horse approach with neutrophils as the carrier. The results showed that inhibiting autophagy could reduce the population of tumor stem-like cells, effectively inhibiting postoperative recurrence and metastasis of breast cancer.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Shuya Zang, Kexin Huang, Jiaxin Li, Kebai Ren, Ting Li, Xuan He, Yuan Tao, Jiao He, Ziyan Dong, Man Li, Qin He
Summary: The study presents a biomimetic nanocarrier for targeted blockade of metabolic support between cancer cells and cancer-associated fibroblasts (CAFs). The nanocarrier effectively increases chemosensitivity of cancer cells, inhibits tumor growth, and reduces lactate production in the tumor microenvironment, leading to enhanced immune response and tumor suppression.
ACTA BIOMATERIALIA
(2022)
Article
Pharmacology & Pharmacy
Yingke Liu, Xingying Qi, Yashi Wang, Man Li, Quan Yuan, Zhihe Zhao
Summary: Oral mucositis (OM) is a common complication of cancer chemotherapy, and its treatment is challenging. In this study, we developed nanomicelles that target inflammation and loaded them with the anti-inflammatory drug cannabidiol (CBD). These nanomicelles showed improved accumulation and retention of CBD, and demonstrated better anti-inflammatory effects compared to free CBD in both local and systemic administration. They also accelerated healing and inhibited inflammatory cell infiltration and transcription. Overall, CBD-loaded nanomicelles show promise for OM treatment.
Review
Pharmacology & Pharmacy
Yingke Liu, Zhihe Zhao, Man Li
Summary: Cell penetrating peptides (CPPs), a class of short peptides capable of translocating drugs across cell membranes, have shown significant potential in drug delivery, particularly in the treatment of cancer, myocardial ischemia, ocular posterior segment disorders, etc. Recent research has focused on CPP-functionalized nano-drug delivery systems, highlighting their promising clinical translation.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Yuan Tao, Yingke Liu, Ziyan Dong, Xiaoxiao Chen, Yashi Wang, Ting Li, Jiaxin Li, Shuya Zang, Xuan He, Dong Chen, Zhihe Zhao, Man Li
Summary: This study developed dandelion-like size-shrinkable nanoparticles for tumor-targeted delivery of hypoxia regulator resveratrol and photodynamic agent chlorine e6, which enhanced the therapeutic effects of photodynamic therapy in oral squamous cell carcinoma by elevating oxygen content in tumor cells and inducing autophagic cell death and apoptosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Zhengze Lu, Ling Ma, Ling Mei, Kebai Ren, Man Li, Ling Zhang, Xiuxiu Liu, Qin He
Summary: The progression of breast cancer stimulates the production of suppressor cells which play a key role in promoting inflammation and immunosuppression. A drug delivery system has been developed to inhibit tumor recurrence and metastasis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Ting Li, Dong Chen, Houqin Liu, Yuan Tao, Xuan He, Shuya Zang, Jiaxin Li, Ling Zhang, Man Li, Ji Liu, Qin He
Summary: The dual-targeting nanoplatform enables simultaneous targeting of tumor-associated macrophages (TAMs) and tumor cells by co-loading gemcitabine and PI3K inhibitor wortmannin, leading to the repolarization of TAMs, activation of antitumor immune response, and improved chemoimmunotherapy outcomes in pancreatic cancer.
Article
Medicine, Research & Experimental
Xiaoxiao Chen, Yuan Tao, Manmin He, Miao Deng, Rong Guo, Qinglin Sheng, Xuhui Wang, Kebai Ren, Ting Li, Xuan He, Shuya Zang, Zhirong Zhang, Man Li, Qin He
Summary: A pH-responsive drug delivery system was formulated to enhance penetration of tumor and inhibit autophagy in pancreatic cancer. Through downregulating MMP-2 and paxillin, as well as reducing fibrosis, the system showed potential in inhibiting proliferation and metastasis of pancreatic cancer.