Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages

Two-Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2-Positive Breast Cancer

(2018) Chunsheng He et al.   ADVANCED FUNCTIONAL MATERIALS

Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer

(2018) Jia Jin et al.   BMC CANCER

Advances in the systemic treatment of triple-negative breast cancer

(2018) J.M. Lebert et al.   Current Oncology

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

Evaluation of phenotypic and functional stability of RAW 264.7 cell line through serial passages

(2018) Bartłomiej Taciak et al.   PLoS One

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

Tumor-associated macrophages in breast cancer: Innocent bystander or important player?

(2018) Si-Qi Qiu et al.   CANCER TREATMENT REVIEWS

Triple-Negative Breast Cancers: Systematic Review of the Literature on Molecular and Clinical Features with a Focus on Treatment with Innovative Drugs

(2018) Anna Diana et al.   Current Oncology Reports

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanomedicine Strategies to Target Tumor-Associated Macrophages

(2017) Karin Binnemars-Postma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer

(2017) Chunsheng He et al.   JOURNAL OF CONTROLLED RELEASE

Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy

(2017) Song Shen et al.   NANO LETTERS

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Integrin-targeted peptide- and peptidomimetic-drug conjugates for the treatment of tumors

(2017) Daniela Arosio et al.   Recent Patents on Anti-Cancer Drug Discovery

Targeting tumor associated macrophages: The new challenge for nanomedicine

(2017) Fernando Torres Andón et al.   SEMINARS IN IMMUNOLOGY

Cellular uptake mechanism and comparative evaluation of antineoplastic effects of paclitaxel–cholesterol lipid emulsion on triple-negative and non-triple-negative breast cancer cell lines

(2016) Jun Ye et al.   International Journal of Nanomedicine

A New Method for Evaluating Actual Drug Release Kinetics of Nanoparticles inside Dialysis Devices via Numerical Deconvolution

(2016) Yousheng Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Nanomedicine of synergistic drug combinations for cancer therapy – Strategies and perspectives

(2016) Rui Xue Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Polymer–lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin–mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor

(2016) Rui Xue Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases

(2016) Nora Rippaus et al.   Oncotarget

Emerging Strategies for Treating Brain Metastases from Breast Cancer

(2015) David P. Kodack et al.   CANCER CELL

Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple-Negative Breast Cancer

(2015) Jenny G. Parvani et al.   CANCER RESEARCH

Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle

(2015) Mark J. Ernsting et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticles coated with the tumor-penetrating peptide iRGD reduce experimental breast cancer metastasis in the brain

(2015) Amanda M. Hamilton et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer

(2014) Jason Li et al.   ACS Nano

Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy

(2014) Yinan Zhong et al.   BIOMACROMOLECULES

Tumor penetrability and anti-angiogenesis using iRGD-mediated delivery of doxorubicin-polymer conjugates

(2014) Ke Wang et al.   BIOMATERIALS

COX-2 Drives Metastatic Breast Cells from Brain Lesions into the Cerebrospinal Fluid and Systemic Circulation

(2014) J. E. Allen et al.   CANCER RESEARCH

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

Synergistic Nanoparticulate Drug Combination Overcomes Multidrug Resistance, Increases Efficacy, and Reduces Cardiotoxicity in a Nonimmunocompromised Breast Tumor Model

(2014) Adam J. Shuhendler et al.   MOLECULAR PHARMACEUTICS

Specific Deletion of LDL Receptor-Related Protein on Macrophages Has Skewed In Vivo Effects on Cytokine Production by Invariant Natural Killer T Cells

(2014) Roman Covarrubias et al.   PLoS One

RGD-conjugated solid lipid nanoparticles inhibit adhesion and invasion of αvβ3 integrin-overexpressing breast cancer cells

(2014) Dan Shan et al.   Drug Delivery and Translational Research

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Myeloid Cell Receptor LRP1/CD91 Regulates Monocyte Recruitment and Angiogenesis in Tumors

(2013) Nicole D. Staudt et al.   CANCER RESEARCH

αv-Integrin isoform expression in primary human tumors and brain metastases

(2013) Alexander Vogetseder et al.   INTERNATIONAL JOURNAL OF CANCER

Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles

(2012) Erkki Ruoslahti   ADVANCED MATERIALS

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Design of pH-responsive nanoparticles of terpolymer of poly(methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin

(2012) Alireza Shalviri et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells

(2012) Alireza Shalviri et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (BBB)

(2012) Jörg Kreuter   JOURNAL OF MICROENCAPSULATION

RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis

(2012) Fabienne Danhier et al.   MOLECULAR PHARMACEUTICS

Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model

(2012) Sylvia Wagner et al.   PLoS One

A Novel Solid Lipid Nanoparticle Formulation for Active Targeting to Tumor αvβ3Integrin Receptors Reveals Cyclic RGD as A Double-Edged Sword

(2012) Adam J. Shuhendler et al.   Advanced Healthcare Materials

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

LDL Receptor-Related Protein 1 Regulates the Abundance of Diverse Cell-Signaling Proteins in the Plasma Membrane Proteome

(2010) Alban Gaultier et al.   JOURNAL OF PROTEOME RESEARCH

The role of the organ microenvironment in brain metastasis

(2010) Isaiah J. Fidler   SEMINARS IN CANCER BIOLOGY

A novel doxorubicin-mitomycin C co-encapsulated nanoparticle formulation exhibits anti-cancer synergy in multidrug resistant human breast cancer cells

(2009) Adam J. Shuhendler et al.   BREAST CANCER RESEARCH AND TREATMENT

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Activation of tumor cell integrin  v 3 controls angiogenesis and metastatic growth in the brain

(2009) M. Lorger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer

(2008) Nancy U. Lin et al.   CANCER