The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health

Intracellular Calcium Dysregulation by the Alzheimer’s Disease-Linked Protein Presenilin 2

(2020) Luisa Galla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal ensemble-specific DNA methylation strengthens engram stability

(2020) Kubra Gulmez Karaca et al.   Nature Communications

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit

(2020) Mehrab N. Modi et al.   Annual Review of Neuroscience

Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium

(2020) Rebekah Mahoney et al.   Cell Reports

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

(2019) Francesco Paonessa et al.   Cell Reports

Transient Receptor Potential Channels and Calcium Signaling

(2019) Laura Vangeel et al.   Cold Spring Harbor Perspectives in Biology

Structure and Function of IP3 Receptors

(2019) David L. Prole et al.   Cold Spring Harbor Perspectives in Biology

Redox regulation of ER and mitochondrial Ca2+ signaling in cell survival and death

(2019) Suresh K. Joseph et al.   CELL CALCIUM

Cytoplasmic and Mitochondrial Calcium Signaling: A Two-Way Relationship

(2019) Benjamin Wacquier et al.   Cold Spring Harbor Perspectives in Biology

The neural circuit linking mushroom body parallel circuits induces memory consolidation in Drosophila

(2019) Hiroko Awata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAADP Receptors

(2019) Antony Galione   Cold Spring Harbor Perspectives in Biology

Fundamentals of Cellular Calcium Signaling: A Primer

(2019) Martin D. Bootman et al.   Cold Spring Harbor Perspectives in Biology

Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cδ-4 (PLCδ4)

(2019) Marcelo Coutinho de Miranda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal Ca2+ Homeostasis and Signaling in Health and Disease

(2019) Emyr Lloyd-Evans et al.   Cold Spring Harbor Perspectives in Biology

Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription

(2019) Yongchuan Zhu et al.   Nature Communications

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

(2019) Bilal R. Malik et al.   Molecular Brain

Nuclear localization of NCX: Role in Ca2+ handling and pathophysiological implications

(2019) Agnese Secondo et al.   CELL CALCIUM

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

(2019) Elena Britti et al.   CELL CALCIUM

Neurons that Function within an Integrator to Promote a Persistent Behavioral State in Drosophila

(2019) Yonil Jung et al.   NEURON

The regulation of autophagy by calcium signals: Do we have a consensus?

(2018) Martin D. Bootman et al.   CELL CALCIUM

Rewiring the connectome: Evidence and effects

(2018) Sophie H. Bennett et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

MeCP2 as an Activator of Gene Expression

(2018) Patricia M. Horvath et al.   TRENDS IN NEUROSCIENCES

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Developmental Coordination during Olfactory Circuit Remodeling in Drosophila

(2018) Oded Mayseless et al.   NEURON

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

(2018) Garrett L. Cornelison et al.   AGING CELL

Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells

(2017) Shinwon Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

(2017) Hilmar Bading   JOURNAL OF EXPERIMENTAL MEDICINE

Reciprocal Interaction of Dendrite Geometry and Nuclear Calcium–VEGFD Signaling Gates Memory Consolidation and Extinction

(2017) Thekla J. Hemstedt et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants

(2017) Manish Verma et al.   JOURNAL OF NEUROSCIENCE

Dendritic spines: Morphological building blocks of memory

(2017) Menahem Segal   NEUROBIOLOGY OF LEARNING AND MEMORY

Temporal calcium profiling of specific circadian neurons in freely moving flies

(2017) Fang Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoscale invaginations of the nuclear envelope: Shedding new light on wormholes with elusive function

(2017) Ingmar Schoen et al.   Nucleus

Nanoscale invaginations of the nuclear envelope: Shedding new light on wormholes with elusive function

(2017) Ingmar Schoen et al.   Nucleus

Endoplasmic Reticulum–Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival

(2017) Hristina Ivanova et al.   Frontiers in Oncology

The Nuclear Pore Complex as a Flexible and Dynamic Gate

(2016) Kevin E. Knockenhauer et al.   CELL

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer’s Disease

(2016) Mario Agostini et al.   CELL CALCIUM

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

(2016) Bess Frost et al.   CURRENT BIOLOGY

Lysosomal signaling in control of degradation pathways

(2016) Lukas A Huber et al.   CURRENT OPINION IN CELL BIOLOGY

Simple rules for passive diffusion through the nuclear pore complex

(2016) Benjamin L. Timney et al.   JOURNAL OF CELL BIOLOGY

Deep nuclear invaginations are linked to cytoskeletal filaments – integrated bioimaging of epithelial cells in 3D culture

(2016) Danielle M. Jorgens et al.   JOURNAL OF CELL SCIENCE

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

DNA methylation in the gene body influences MeCP2-mediated gene repression

(2016) Benyam Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

(2016) Anna Raffaello et al.   TRENDS IN BIOCHEMICAL SCIENCES

Second Messengers

(2016) Alexandra C. Newton et al.   Cold Spring Harbor Perspectives in Biology

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

(2016) Kavya Reddy et al.   Cell Reports

Regulation of neuronal communication by G protein-coupled receptors

(2015) Yunhong Huang et al.   FEBS LETTERS

Dnmt3a2: a hub for enhancing cognitive functions

(2015) A M M Oliveira et al.   MOLECULAR PSYCHIATRY

Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice

(2015) Furong Wang et al.   NEUROPHARMACOLOGY

Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease

(2015) Li Wang et al.   NEUROPHARMACOLOGY

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

(2015) Marko Kostic et al.   Cell Reports

Induction of macroautophagy by exogenously introduced calcium

(2014) Wentao Gao et al.   Autophagy

γCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression

(2014) Huan Ma et al.   CELL

Neuronal calcium signaling: function and dysfunction

(2014) Marisa Brini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Components and regulation of nuclear transport processes

(2014) Bastien Cautain et al.   FEBS Journal

Enhancing Astrocytic Lysosome Biogenesis Facilitates A  Clearance and Attenuates Amyloid Plaque Pathogenesis

(2014) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

(2014) Boxing Li et al.   NATURE NEUROSCIENCE

Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination

(2014) Andrew C Lin et al.   NATURE NEUROSCIENCE

The neuronal architecture of the mushroom body provides a logic for associative learning

(2014) Yoshinori Aso et al.   eLife

Transient knockdown of presenilin-1 provokes endoplasmic reticulum stress related formation of autophagosomes in HepG2 cells

(2013) Péter Száraz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Calcium responses to synaptically activated bursts of action potentials and their synapse-independent replay in cultured networks of hippocampal neurons

(2013) C. Peter Bengtson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear Calcium Signaling Regulates Nuclear Export of a Subset of Class IIa Histone Deacetylases following Synaptic Activity

(2013) Friederike Schlumm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium regulation of neural rhythms, memory and Alzheimer's disease

(2013) Michael J. Berridge   JOURNAL OF PHYSIOLOGY-LONDON

Nuclear calcium signalling in the regulation of brain function

(2013) Hilmar Bading   NATURE REVIEWS NEUROSCIENCE

Nuclear Calcium Signaling in Spinal Neurons Drives a Genomic Program Required for Persistent Inflammatory Pain

(2013) Manuela Simonetti et al.   NEURON

Neuron-specific chromatin remodeling: A missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders

(2013) Annie Vogel-Ciernia et al.   NEUROPHARMACOLOGY

The Histone Deacetylase HDAC4 Regulates Long-Term Memory in Drosophila

(2013) Helen L. Fitzsimons et al.   PLoS One

Requirement for Nuclear Calcium Signaling in Drosophila Long-Term Memory

(2013) J.-M. Weislogel et al.   Science Signaling

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

(2012) Patricia Vázquez et al.   Autophagy

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

(2012) Richard Sando et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Nuclear Calcium Signaling Controls Methyl-CpG-binding Protein 2 (MeCP2) Phosphorylation on Serine 421 following Synaptic Activity

(2012) Bettina Buchthal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

(2012) M.-S. Kim et al.   JOURNAL OF NEUROSCIENCE

Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities

(2012) Ana M M Oliveira et al.   NATURE NEUROSCIENCE

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

The Human Nuclear Pore Complex as Revealed by Cryo-Electron Tomography

(2012) Tal Maimon et al.   STRUCTURE

The Role of MeCP2 in the Brain

(2011) Jacky Guy et al.   Annual Review of Cell and Developmental Biology

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Nuclear Calcium-VEGFD Signaling Controls Maintenance of Dendrite Arborization Necessary for Memory Formation

(2011) Daniela Mauceri et al.   NEURON

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The nucleoplasmic reticulum: form and function

(2011) Ashraf Malhas et al.   TRENDS IN CELL BIOLOGY

The Ca2+ Pumps of the Endoplasmic Reticulum and Golgi Apparatus

(2011) I. Vandecaetsbeek et al.   Cold Spring Harbor Perspectives in Biology

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

(2010) Silvia Carloni et al.   Autophagy

Nuclear Calcium Sensors Reveal that Repetition of Trains of Synaptic Stimuli Boosts Nuclear Calcium Signaling in CA1 Pyramidal Neurons

(2010) C. Peter Bengtson et al.   BIOPHYSICAL JOURNAL

Intracellular Ca2+ storage in health and disease: A dynamic equilibrium

(2010) Eva Sammels et al.   CELL CALCIUM

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases

(2010) David C. Bedford et al.   Epigenetics

Refinement of Tools for Targeted Gene Expression in Drosophila

(2010) B. D. Pfeiffer et al.   GENETICS

Synaptic Activity and Nuclear Calcium Signaling Protect Hippocampal Neurons from Death Signal-associated Nuclear Translocation of FoxO3a Induced by ExtrasynapticN-Methyl-d-aspartate Receptors

(2010) Oliver Dick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Brain function and chromatin plasticity

(2010) Catherine Dulac   NATURE

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Regional and subcellular distribution of HDAC4 in mouse brain

(2009) Michael J. Darcy et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Synaptic Activity Induces Dramatic Changes in the Geometry of the Cell Nucleus: Interplay between Nuclear Structure, Histone H3 Phosphorylation, and Nuclear Calcium Signaling

(2009) M. Wittmann et al.   JOURNAL OF NEUROSCIENCE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

(2009) Sheng-Jia Zhang et al.   PLoS Genetics

How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane

(2008) Chikashi Toyoshima   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear calcium signaling: a cell within a cell

(2008) M.A. Rodrigues et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Insulin induces calcium signals in the nucleus of rat hepatocytes

(2008) Michele A. Rodrigues et al.   HEPATOLOGY

Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum

(2008) Kenjiro Sakaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

Re-positioning genes to the nuclear envelope in mammalian cells: impact on transcription

(2008) Myriam Ruault et al.   TRENDS IN GENETICS