Article
Plant Sciences
Yuling Liu, Luying Zhao, Xinyunxi He, Yi Shen, Na Wang, Sijing Hu, Jinlong Xu, Qiming Zhao, Quanlong Zhang, Luping Qin, Qiaoyan Zhang
Summary: Tiger bone, a traditional Chinese medicine, has been used to treat bone diseases. Artificial tiger bone JTG, approved for osteoporosis relief, has similar chemical profile and has been shown to protect bone loss. This study found that JTG proteins can promote osteogenesis and enhance autophagy through the PI3K/AKT and ER stress pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Ankang Hu, Jing Liu, Yonghui Wang, Maoyin Zhang, Yao Guo, Ying Qin, Tingya Liu, Yanjuan Men, Quangang Chen, Tingjun Liu
Summary: This study found that rafoxanide significantly inhibits the growth, invasion, and migration of non-small cell lung cancer cells by inducing apoptosis and cell cycle arrest. It also induces endoplasmic reticulum stress and activates the unfolded protein response. In vivo models showed that rafoxanide effectively inhibits tumor growth.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Review
Biochemistry & Molecular Biology
Debora Gentile, Marianna Esposito, Paolo Grumati
Summary: Autophagy is a cellular cleaning system that maintains metabolic balance and plays a crucial role in sustaining malignant cellular growth during tumorigenesis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Keisuke Mochida, Hitoshi Nakatogawa
Summary: Autophagy is a degradation system in eukaryotic cells that controls the mass and functions of organelles by degrading excess or defective portions. The endoplasmic reticulum (ER) is an organelle with specific functions that dynamically changes its mass and shape to maintain or regulate its functions. Elaborate mechanisms are required for the proper degradation of the ER.
Review
Biotechnology & Applied Microbiology
Ting Cao, Binfeng Peng, Xiangping Zhou, Jialun Cai, Yun Tang, Jie Luo, Haitao Xie, Ji Zhang, Shuangquan Liu
Summary: The endoplasmic reticulum (ER) is a crucial multifunctional organelle responsible for correct folding and assembly of secretory and transmembrane proteins. Perturbations in ER function can lead to ER stress, activating the unfolded protein response (UPR) to cope with misfolded protein accumulation. If the imbalance cannot be restored, it may lead to cell death or diseases. The UPR is a coordination system that regulates transcription and translation to help cells recover ER homeostasis. The integrated signaling system in cells includes ER-associated degradation (ERAD), autophagy, hypoxia signaling, and mitochondrial biogenesis to cope with ER stress.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Veronik Lachance, Sara-Maude Belanger, Celia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, Said Kourrich
Summary: In recent years, research on the Sigma-1R (S1R) protein has shown its importance in maintaining cellular homeostasis through modulation of calcium and lipid exchange, ER-stress response, and other mechanisms. Many of these processes have been linked to neuroprotective roles, and using S1R agonists to improve these mechanisms has shown benefits in treating brain disorders. This review article explores the subcellular localization and biological activity of S1R within specific compartments, and discusses how dysregulation of these pathways contributes to neurodegenerative diseases, highlighting key binding partners and cellular mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jingping Ren, Wei Zeng, Changsheng Jiang, Chang Li, Chengjun Zhang, Hua Cao, Wentao Li, Qigai He
Summary: Porcine epidemic diarrhea virus (PEDV) causes detrimental effects on the global swine industry. The study demonstrates that cinchonine can effectively inhibit PEDV replication by inducing cellular autophagy, suggesting its potential as a novel antiviral agent.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jianguo Liu, Rendong Qiu, Ran Liu, Pengjie Song, Pengfei Lin, Huatao Chen, Dong Zhou, Aihua Wang, Yaping Jin
Summary: This study found that primary bovine endometrial epithelial cells (bEECs) expressed an inflammatory response through the assembly of the NLRP3 inflammasome and activation of the NF-kappa B p65 subunit during Escherichia coli (E. coli) infection. E. coli infection also led to an abnormal increase in cytoplasmic calcium and mitochondrial dysfunction. The increase in cytosolic calcium was mainly caused by the release of calcium ions stored in the endoplasmic reticulum and mitochondria. Cytoplasmic calcium regulates mitochondrial respiratory chain transmission, DNA replication, and biogenesis. Activation of autophagy inhibited the release of inflammatory substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cell Biology
Marijn Kuijpers, Volker Haucke
Summary: The role of macroautophagy/autophagy in neurons and the physiological substrates in healthy neurons are still largely unknown. Research has shown that loss of neuronal autophagy can affect neurotransmission and calcium homeostasis in axonal and synaptic regions.
Review
Neurosciences
Melissa A. Hill, Alex M. Sykes, George D. Mellick
Summary: There are various cellular mechanisms involved in neurodegenerative diseases, and the accumulation of unwanted cellular products with age is a common factor. Autophagy plays a significant role in maintaining neuronal homeostasis and disruption in autophagy can contribute to disease development. Recently, the role of ER-phagy in regulating ER morphology and response to cellular stress has been explored in relation to neurodegenerative diseases. This review discusses current research on ER-phagy and its involvement in these diseases.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Review
Endocrinology & Metabolism
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: The endoplasmic reticulum (ER) is an active organelle involved in various physiological processes. Recent studies have shown that dysfunction of the ER plays a role in the progression of kidney disease, particularly diabetic nephropathy (DN). This review discusses the function of the ER, the regulation of homeostasis through the unfolded protein response (UPR) and ER-phagy, as well as the impact of abnormal ER homeostasis in renal cells in DN. Additionally, potential therapeutic targets for DN related to maintaining ER homeostasis are also explored.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Yan
Summary: The study demonstrated that chronic exposure to ACR can impair motor skills, muscle strength, and coordination in rats, as well as damage the morphology of the cerebellum, leading to increased apoptosis and initiation of autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Cell Biology
Ming Yang, Shilu Luo, Xi Wang, Chenrui Li, Jinfei Yang, Xuejing Zhu, Li Xiao, Lin Sun
Summary: The endoplasmic reticulum (ER) is crucial for maintaining cellular homeostasis, and ER-phagy, a selective form of autophagy, helps remove damaged ER to protect cells from harm caused by excessive ER stress. Many receptor-mediated ER-phagy pathways have been discovered in recent years, highlighting the importance of this newly identified autophagy process in maintaining cellular health.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Csilla E. Nemeth, Paola Marcolongo, Alessandra Gamberucci, Rosella Fulceri, Angiolo Benedetti, Nicoletta Zoppi, Marco Ritelli, Nicola Chiarelli, Marina Colombi, Andy Willaert, Bert L. Callewaert, Paul J. Coucke, Pal Grof, Szilvia K. Nagy, Tamas Meszaros, Gabor Banhegyi, Eva Margittai
Article
Cell Biology
Lucia Funghi, Francesco Damiani, Chih-Feng Yen, Chyi-Long Lee, Annalia Lombardi, Frederick Schatz, Charles J. Lockwood, Paola Marcolongo, Felice Petraglia, Felice Arcuri
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Alessandra Gamberucci, Paola Marcolongo, Csilla E. Nemeth, Nicoletta Zoppi, Andras Szarka, Nicola Chiarelli, Tamas Hegedus, Marco Ritelli, Giulia Carini, Andy Willaert, Bert L. Callewaert, Paul J. Coucke, Angiolo Benedetti, Eva Margittai, Rosella Fulceri, Gabor Banhegyi, Marina Colombi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Cell Biology
Francesco Damiani, Sofia Makieva, Sara F. Rinaldi, Lei Hua, Paola Marcolongo, Felice Petraglia, Jane E. Norman
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2017)
Review
Nutrition & Dietetics
Balazs Legeza, Paola Marcolongo, Alessandra Gamberucci, Viola Varga, Gabor Banhegyi, Angiolo Benedetti, Alex Odermatt
Article
Endocrinology & Metabolism
Federica Raggi, Anna Livia Pissavino, Roberta Resaz, Daniela Segalerba, Andrea Puglisi, Cristina Vanni, Francesca Antonini, Genny Del Zotto, Alessandra Gamberucci, Paola Marcolongo, Maria Carla Bosco, Federica Grillo, Luca Mastracci, Alessandra Eva
JOURNAL OF INHERITED METABOLIC DISEASE
(2018)
Article
Food Science & Technology
Gabriella Tamasi, Alessio Pardini, Claudia Bonechi, Alessandro Donati, Federica Pessina, Paola Marcolongo, Alessandra Gamberucci, Gemma Leone, Marco Consumi, Agnese Magnani, Claudio Rossi
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Viola Varga, Zsofia Muranyi, Anita Kurucz, Paola Marcolongo, Angelo Benedetti, Gabor Banhegyi, Eva Margittai
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Beata Lizak, Andras Szarka, Yejin Kim, Kyu-sung Choi, Csilla E. Nemeth, Paola Marcolongo, Angelo Benedetti, Gabor Banhegyi, Eva Margittai
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Obstetrics & Gynecology
Barbara Del Bello, Paola Marcolongo, Pasquapina Ciarmela, Flavia Sorbi, Felice Petraglia, Stefano Luisi, Emilia Maellaro
FERTILITY AND STERILITY
(2019)
Article
Multidisciplinary Sciences
Federica Pessina, Maria Frosini, Paola Marcolongo, Fabio Fusi, Simona Saponara, Alessandra Gamberucci, Massimo Valoti, Daniela Giustarini, Paolo Fiorenzani, Beatrice Gorelli, Valeria Francardi, Maurizio Botta, Elena Dreassi
Article
Biochemistry & Molecular Biology
Paola Marcolongo, Alessandra Gamberucci, Gabriella Tamasi, Alessio Pardini, Claudia Bonechi, Claudio Rossi, Roberta Giunti, Virginia Barone, Annalisa Borghini, Paolo Fiorenzani, Maria Frosini, Massimo Valoti, Federica Pessina
Letter
Dermatology
Linda Tognetti, Francesco Damiani, Camilla Marrocco, Giancarlo Mariotti, Emanuele Trovato, Elisa Cinotti, Paola Marcolongo, Michele Pellegrino, Pietro Rubegni
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Nutrition & Dietetics
Roberto Stella, Caterina Peggion, Caterina Bergantin, Giancarlo Biancotto, Maria Frosini, Elena Dreassi, Paola Marcolongo, Anna Maria Aloisi, Federica Pessina
Summary: Hypertension is a leading risk factor for premature death globally, and TM dietary supplementation has been shown to be effective in treating hypertension. This study used proteomics and metabolomics techniques to uncover the underlying mechanism of TM's effects on hypertension treatment.
Article
Pathology
Maria Frosini, Paola Marcolongo, Alessandra Gamberucci, Gabriella Tamasi, Alessio Pardini, Roberta Giunti, Paolo Fiorenzani, Anna Maria Aloisi, Claudio Rossi, Federica Pessina
Summary: The study found that consuming tomato gel/serum or captopril can significantly reduce blood pressure in hypertensive rats, decrease their locomotor activity, and increase grooming behavior. Tomatine also affects behavioral parameters in rats, but does not have an effect on brain oxidative stress. Tomato gel/serum can reduce brain susceptibility to oxidative stress and lower levels of inflammatory cytokines in hypertensive rats, while tomatine does not have this effect.
Article
Biochemistry & Molecular Biology
Yuri Nagaoka, Kotone Oshiro, Yuta Yoshino, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari
Summary: This study investigated the effect of intercellular adhesion molecule CLDN1 on the anticancer drug sensitivity of small-cell lung cancer (SCLC) cells. It was found that overexpression of CLDN1 decreased the sensitivity of SCLC cells to anticancer drugs and enhanced their migratory capacity through the activation of the TGF-81/EMT signaling pathway. Treatment with EMT inhibitors showed potential in overcoming the reduced sensitivity to anticancer drugs in CLDN1-overexpressing SCLC cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2024)
