Deletion of Dcf1 Reduces Amyloid-β Aggregation and Mitigates Memory Deficits

Dcf1 alleviates C99-mediated deficits in drosophila by reducing the cleavage of C99

(2020) Weihao Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dcf1 deficiency induces hypomyelination by activating Wnt signaling

(2020) Ruili Feng et al.   EXPERIMENTAL NEUROLOGY

Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

(2019) Enjie Liu et al.   Translational Neurodegeneration

DCF1 subcellular localization and its function in mitochondria

(2018) Yanlu Chen et al.   BIOCHIMIE

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

(2018) Xiangyou Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila

(2018) Shiqing Zhang et al.   NEUROBIOLOGY OF AGING

TMEM59 potentiates Wnt signaling by promoting signalosome formation

(2018) Jan P. Gerlach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer’s disease

(2018) Alfonso Martín-Peña et al.   Scientific Reports

Genome-Wide DNA Methylation Differences Between Late-Onset Alzheimer's Disease and Cognitively Normal Controls in Human Frontal Cortex

(2018) Kelly M. Bakulski et al.   JOURNAL OF ALZHEIMERS DISEASE

A role for APP in Wnt signalling links synapse loss with β-amyloid production

(2018) Christina Elliott et al.   Translational Psychiatry

Dcf1 Deficiency Attenuates the Role of Activated Microglia During Neuroinflammation

(2018) Jiao Wang et al.   Frontiers in Molecular Neuroscience

Bis(9)-(−)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice

(2018) Yuhuan Shi et al.   Translational Neurodegeneration

Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition

(2017) Qiang Liu et al.   MOLECULAR NEUROBIOLOGY

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

(2017) Aylin D. Keskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach

(2017) Rodrigo Aguayo-Ortiz et al.   Chemical Science

Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo

(2017) Ramona F. Sowade et al.   Nature Communications

Neuropathological and transcriptomic characteristics of the aged brain

(2017) Jeremy A Miller et al.   eLife

Drosophila Models of Alzheimer's Amyloidosis: The Challenge of Dissecting the Complex Mechanisms of Toxicity of Amyloid-β 42

(2017) Koichi Iijima et al.   JOURNAL OF ALZHEIMERS DISEASE

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease

(2016) T A Pascoal et al.   MOLECULAR PSYCHIATRY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model

(2014) John W. Steele et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Allosteric regulation of  -secretase activity by a phenylimidazole-type  -secretase modulator

(2014) K. Takeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the γ-secretase component nicastrin

(2014) Tian Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site

(2014) Wen Chen et al.   Nature Communications

Overexpression of DCF1 inhibits glioma through destruction of mitochondria and activation of apoptosis pathway

(2014) Yuqiong Xie et al.   Scientific Reports

Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes

(2013) Yi Li et al.   STRUCTURE

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

LTP requires a reserve pool of glutamate receptors independent of subunit type

(2012) Adam J. Granger et al.   NATURE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles

(2011) Luwen Zhang et al.   BMC Systems Biology

GluA2 (GluR2) Regulates Metabotropic Glutamate Receptor-Dependent Long-Term Depression through N-Cadherin-Dependent and Cofilin-Mediated Actin Reorganization

(2011) Z. Zhou et al.   JOURNAL OF NEUROSCIENCE

The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression, and Secretion of the Amyloid Precursor Protein

(2010) Sylvia Ullrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Formation of Long-Term Memory Representation in Human Temporal Cortex Related to Pictorial Paired Associates

(2009) K.-i. Yamashita et al.   JOURNAL OF NEUROSCIENCE

A Novel Function of dcf1 During the Differentiation of Neural Stem Cells In vitro

(2008) Lei Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY