Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

Physical activity during pregnancy and offspring neurodevelopment: A systematic review

(2018) Gloria Isabel Niño Cruz et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

(2018) Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral versus Central Index of Metabolic Dysfunction and Associations with Clinical and Pathological Outcomes in Alzheimer’s Disease

(2017) Kelsey E. McLimans et al.   JOURNAL OF ALZHEIMERS DISEASE

Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP

(2017) Saket M. Nigam et al.   JOURNAL OF NEUROCHEMISTRY

GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory

(2017) Enjie Liu et al.   Scientific Reports

Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer’s Disease

(2016) Jean-Sébastien Vidal et al.   JOURNAL OF ALZHEIMERS DISEASE

Experience Affects Critical Period Plasticity in the Visual Cortex through an Epigenetic Regulation of Histone Post-Translational Modifications

(2016) L. Baroncelli et al.   JOURNAL OF NEUROSCIENCE

Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor  B-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning

(2016) R. Neidl et al.   JOURNAL OF NEUROSCIENCE

Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s disease

(2016) Syed Faraz Kazim et al.   Molecular Neurodegeneration

Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer’s disease: a meta-analysis study (N=7277)

(2016) X-Y Qin et al.   MOLECULAR PSYCHIATRY

Higher brainBDNFgene expression is associated with slower cognitive decline in older adults

(2016) Aron S. Buchman et al.   NEUROLOGY

Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

(2016) Yaling Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons

(2016) Ernest Palomer et al.   Nature Communications

Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet

(2016) Shereen Nizari et al.   Scientific Reports

Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons

(2016) Ernest Palomer et al.   Cell Reports

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model

(2016) M Hüttenrauch et al.   Translational Psychiatry

Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring

(2016) Sérgio Gomes da Silva et al.   PLoS One

Enriched environment restricted to gestation accelerates the development of sensory and motor circuits in the rat pup

(2015) Lorena Cárdenas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Prenatal high-fat diet alters the cerebrovasculature and clearance ofβ-amyloid in adult offspring

(2015) Cheryl A Hawkes et al.   JOURNAL OF PATHOLOGY

Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5

(2015) Emma L Burrows et al.   NEUROPSYCHOPHARMACOLOGY

Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer’s Rodent Models

(2015) Yuanyuan Wu et al.   Scientific Reports

Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer’s disease: an observational study

(2014) Joakim Hertze et al.   BMC Neurology

Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial

(2014) Lisanne F ten Brinke et al.   BRITISH JOURNAL OF SPORTS MEDICINE

MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons

(2014) Woori Kim et al.   MOLECULAR NEUROBIOLOGY

Brain-Derived Neurotrophic Factor in Alzheimer’s Disease: Risk, Mechanisms, and Therapy

(2014) Jing-Hui Song et al.   MOLECULAR NEUROBIOLOGY

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Early life stress in fathers improves behavioural flexibility in their offspring

(2014) Katharina Gapp et al.   Nature Communications

Enriched Early Life Experiences Reduce Adult Anxiety-Like Behavior in Rats: A Role for Insulin-Like Growth Factor 1

(2013) S. Baldini et al.   JOURNAL OF NEUROSCIENCE

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Zhentao Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Physical Activity During Pregnancy and Language Development in the Offspring

(2013) Anne Marie Z. Jukic et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

Prenatal Enriched Environment improves emotional and attentional reactivity to adulthood stress

(2012) Adi Cymerblit-Sabba et al.   BEHAVIOURAL BRAIN RESEARCH

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Parental enrichment and offspring development: Modifications to brain, behavior and the epigenome

(2011) Richelle Mychasiuk et al.   BEHAVIOURAL BRAIN RESEARCH

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

(2011) Sebastian Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

β-Adducin Is Required for Stable Assembly of New Synapses and Improved Memory upon Environmental Enrichment

(2011) Ewa Bednarek et al.   NEURON

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Regulation ofBDNFGene in Response to Stress

(2011) Manabu Fuchikami et al.   Psychiatry Investigation

Effects of exercise training on maternal hormonal changes in pregnancy

(2010) Sarah A. Hopkins et al.   CLINICAL ENDOCRINOLOGY

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice

(2010) Yuan-Shih Hu et al.   FASEB JOURNAL

Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice

(2010) Marie-Caroline Cotel et al.   NEUROBIOLOGY OF AGING

Responses of serum neurotrophic factors to exercise in pregnant and postpartum women

(2010) Sandra Rojas Vega et al.   PSYCHONEUROENDOCRINOLOGY

Can Cognitive Exercise Prevent the Onset of Dementia? Systematic Review of Randomized Clinical Trials with Longitudinal Follow-up

(2009) Michael Valenzuela et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Setting the Pace for Retinal Development: Environmental Enrichment Acts Through Insulin-Like Growth Factor 1 and Brain-Derived Neurotrophic Factor

(2009) S. Landi et al.   JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression

(2009) M. Rohe et al.   JOURNAL OF NEUROSCIENCE

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

(2009) D K Lahiri et al.   MOLECULAR PSYCHIATRY

Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease

(2008) Nicola T. Lautenschlager et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION