In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives

A role for orphan nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) in primordial follicle activation

(2021) Marie-Charlotte Meinsohn et al.   Scientific Reports

Current mechanisms of primordial follicle activation and new strategies for fertility preservation

(2021) Yan Zhang et al.   MOLECULAR HUMAN REPRODUCTION

Drug-free in-vitro activation of ovarian cortex; can it really activate the ‘ovarian gold reserve’?

(2020) Georg Griesinger et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development

(2020) Beatriz Peñalver Bernabé et al.   Reproductive Sciences

Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing

(2020) Mila Maidarti et al.   Cells

A genome-wide association study of polycystic ovary syndrome identified from electronic health records

(2020) Yanfei Zhang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Peroxisome Proliferator-Activated Receptor Gamma Modulator Promotes Neonatal Mouse Primordial Follicle Activation In Vitro

(2020) Sook Young Yoon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hippo signaling disruption and ovarian follicle activation in infertile patients

(2020) Aaron J.W. Hsueh et al.   FERTILITY AND STERILITY

Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause

(2020) E Ouni et al.   HUMAN REPRODUCTION

Human Follicle in vitro Culture Including Activation, Growth, and Maturation: A Review of Research Progress

(2020) Qiyu Yang et al.   Frontiers in Endocrinology

Surgical approaches of drug-free in vitro activation and laparoscopic ovarian incision to treat patients with ovarian infertility

(2020) Yuka Tanaka et al.   FERTILITY AND STERILITY

In vivo and in vitro activation of dormant primordial follicles by EGF treatment in mouse and human

(2020) Jiawei Zhang et al.   Clinical and Translational Medicine

The effect of bpV(HOpic) on in vitro activation of primordial follicles in cultured swine ovarian cortical strips

(2019) Natalie Raffel et al.   REPRODUCTION IN DOMESTIC ANIMALS

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

(2019) Xiangmin Lv et al.   FASEB JOURNAL

SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles

(2019) Sofia Granados-Aparici et al.   Scientific Reports

Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes

(2019) Go Nagamatsu et al.   Science Advances

Drug-free In Vitro Activation (IVA) of follicles for infertility treatment in poor ovarian response patients with decreased ovarian reserve

(2019) Kazuhiro Kawamura et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Interaction between PI3K/AKT and Hippo pathways during in vitro follicular activation and response to fragmentation and chemotherapy exposure using a mouse immature ovary model

(2019) Melody Devos et al.   BIOLOGY OF REPRODUCTION

Biopsying, fragmentation and autotransplantation of fresh ovarian cortical tissue in infertile women with diminished ovarian reserve

(2019) Stine Aagaard Lunding et al.   HUMAN REPRODUCTION

Drug- free in vitro activation of follicles and fresh tissue autotransplantation as a therapeutic option in primary ovarian insufficiency patients

(2019) Janisse Ferreri et al.   REPRODUCTIVE BIOMEDICINE ONLINE

The Hippo pathway integrates PI3K–Akt signals with mechanical and polarity cues to control tissue growth

(2019) Nerea Borreguero-Muñoz et al.   PLOS BIOLOGY

SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription

(2019) Tuo Zhang et al.   FASEB JOURNAL

Sphingosine-1-phosphate protects human ovarian follicles from apoptosis in vitro

(2018) Yilmaz Guzel et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Granulosa cells from human primordial and primary follicles show differential global gene expression profiles

(2018) E H Ernst et al.   HUMAN REPRODUCTION

Dynamics of PI3K and Hippo signaling pathways during in vitro human follicle activation

(2018) J Grosbois et al.   HUMAN REPRODUCTION

Preliminary human application of optical coherence tomography for quantification and localization of primordial follicles aimed at effective ovarian tissue transplantation

(2018) Seido Takae et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system

(2018) M McLaughlin et al.   MOLECULAR HUMAN REPRODUCTION

In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies

(2018) Michael J. Bertoldo et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Imaging the ovary

(2018) Yi Feng et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Forty years of IVF

(2018) Craig Niederberger et al.   FERTILITY AND STERILITY

Hippo signaling in the ovary and polycystic ovarian syndrome

(2018) Kristi Maas et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

GDF-9 and BMP-15 direct the follicle symphony

(2018) Alexandra Sanfins et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Nuclear exclusion of SMAD2/3 in granulosa cells is associated with primordial follicle activation in the mouse ovary

(2018) Kate Hardy et al.   JOURNAL OF CELL SCIENCE

Hippo pathway functions as a downstream effector of AKT signaling to regulate the activation of primordial follicles in mice

(2018) Liao-Liao Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review

(2018) F. Fabregues et al.   Journal of Ovarian Research

Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response

(2018) Mila Maidarti et al.   HUMAN REPRODUCTION

Neurotrophins and glial cell line-derived neurotrophic factor in the ovary: physiological and pathophysiological implications

(2018) Hsun-Ming Chang et al.   HUMAN REPRODUCTION UPDATE

Dormancy and activation of human oocytes from primordial and primary follicles: molecular clues to oocyte regulation

(2017) E.H. Ernst et al.   HUMAN REPRODUCTION

Follicle activation is a significant and immediate cause of follicle loss after ovarian tissue transplantation

(2017) Zohar Gavish et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome

(2017) Li-Le Jiang et al.   MEDICINE

Anti-Müllerian hormone inhibits activation and growth of bovine ovarian follicles in vitro and is localized to growing follicles

(2017) M.Y. Yang et al.   MOLECULAR HUMAN REPRODUCTION

Restricting the induction of NGF in ovarian stroma engenders selective follicular activation through the mTOR signaling pathway

(2017) Yuanlin He et al.   Cell Death & Disease

Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary

(2017) Seido Takae et al.   Scientific Reports

Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis1

(2016) Laleh Abbassi et al.   BIOLOGY OF REPRODUCTION

Activation of dormant follicles

(2016) Kazuhiro Kawamura et al.   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

In Vitro Activation of Follicles and Fresh Tissue Auto-transplantation in Primary Ovarian Insufficiency Patients

(2016) Jun Zhai et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of the key regulating genes of diminished ovarian reserve (DOR) by network and gene ontology analysis

(2016) Maryam Pashaiasl et al.   MOLECULAR BIOLOGY REPORTS

Inhibitors of c-Jun phosphorylation impede ovine primordial follicle activation

(2016) Michael J. Bertoldo et al.   MOLECULAR HUMAN REPRODUCTION

Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15

(2016) Karen L. Reader et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

In Vitro Activation

(2016) Christina N. Cordeiro et al.   Reproductive Sciences

Supplementation of transport and freezing media with anti-apoptotic drugs improves ovarian cortex survival

(2016) Laurie Henry et al.   Journal of Ovarian Research

New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators

(2015) Xinhui Sun et al.   CELL CYCLE

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

(2015) Carsten Gram Hansen et al.   CELL RESEARCH

Hippo Signaling Pathway Reveals a Spatio-Temporal Correlation with the Size of Primordial Follicle Pool in Mice

(2015) Cheng Xiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Intraovarian Control of Early Folliculogenesis

(2015) Aaron J. W. Hsueh et al.   ENDOCRINE REVIEWS

Cell Autonomous Phosphoinositide 3-Kinase Activation in Oocytes Disrupts Normal Ovarian Function Through Promoting Survival and Overgrowth of Ovarian Follicles

(2015) So-Youn Kim et al.   ENDOCRINOLOGY

Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP

(2015) Yuan Cheng et al.   FASEB JOURNAL

Optimizing outcomes from ovarian tissue cryopreservation and transplantation; activation versus preservation

(2015) Dror Meirow et al.   HUMAN REPRODUCTION

Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency

(2015) Nao Suzuki et al.   HUMAN REPRODUCTION

Promotion of Ovarian Follicle Growth following mTOR Activation: Synergistic Effects of AKT Stimulators

(2015) Yuan Cheng et al.   PLoS One

GDF9 is Transiently Expressed in Oocytes before Follicle Formation in the Human Fetal Ovary and is Regulated by a Novel NOBOX Transcript

(2015) Rosemary A. L. Bayne et al.   PLoS One

Short-Term PTEN Inhibition Improves In Vitro Activation of Primordial Follicles, Preserves Follicular Viability, and Restores AMH Levels in Cryopreserved Ovarian Tissue From Cancer Patients

(2015) Edurne Novella-Maestre et al.   PLoS One

Follicle activation and 'burn-out' contribute to post-transplantation follicle loss in ovarian tissue grafts: the effect of graft thickness

(2014) Z. Gavish et al.   HUMAN REPRODUCTION

Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles

(2014) M. McLaughlin et al.   MOLECULAR HUMAN REPRODUCTION

mTORC1 Signaling in Oocytes Is Dispensable for the Survival of Primordial Follicles and for Female Fertility

(2014) Nagaraju Gorre et al.   PLoS One

Ovarian follicle culture: advances and challenges for human and nonhuman primates

(2013) Evelyn E. Telfer et al.   FERTILITY AND STERILITY

Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death

(2013) F. Li et al.   HUMAN REPRODUCTION

Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles

(2013) Galit Lerer-Serfaty et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Cross-Ethnic Meta-Analysis of Genetic Variants for Polycystic Ovary Syndrome

(2013) Yvonne V. Louwers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rapamycin-sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary

(2013) Yuanyuan Tong et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

(2013) K. Kawamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Hippo signalling: a kinase network regulated by protein–protein interactions: Figure 1

(2012) Alexander Hergovich   BIOCHEMICAL SOCIETY TRANSACTIONS

The Role of Anti-Müllerian Hormone (AMH) During Follicle Development in a Monovulatory Species (Sheep)

(2012) Bruce K. Campbell et al.   ENDOCRINOLOGY

Kit ligand and glial-derived neurotrophic factor as alternative supplements for activation and development of ovine preantral follicles in vitro

(2012) F. Esmaielzadeh et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

The Safe Use of a PTEN Inhibitor for the Activation of Dormant Mouse Primordial Follicles and Generation of Fertilizable Eggs

(2012) Deepak Adhikari et al.   PLoS One

FSH prevents depletion of the resting follicle pool by promoting follicular number and morphology in fresh and cryopreserved primate ovarian tissues following xenografting

(2012) Viktoria von Schönfeldt et al.   Reproductive Biology and Endocrinology

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

Growth Differentiating Factor 9 (GDF9) and Bone Morphogenetic Protein 15 both Activate Development of Human Primordial Folliclesin vitro, with Seemingly More Beneficial Effects of GDF9

(2011) Alon Kedem et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Functional roles of the phosphatidylinositol 3-kinases (PI3Ks) signaling in the mammalian ovary

(2011) Wenjing Zheng et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Connective Tissue Growth Factor Is Required for Normal Follicle Development and Ovulation

(2011) Takashi Nagashima et al.   MOLECULAR ENDOCRINOLOGY

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Signalling pathways involved in the cooperative effects of ovine and murine GDF9+BMP15-stimulated thymidine uptake by rat granulosa cells

(2011) Karen L Reader et al.   REPRODUCTION

LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity

(2010) Margareta D. Pisarska et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Neurotrophin 4 enhances in vitro follicular assembly in human fetal ovaries

(2010) Jacob Farhi et al.   FERTILITY AND STERILITY

Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation

(2010) J. Smitz et al.   HUMAN REPRODUCTION UPDATE

Primary ovarian insufficiency

(2010) Michel De Vos et al.   LANCET

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

(2010) Zi-Jiang Chen et al.   NATURE GENETICS

Activation of dormant ovarian follicles to generate mature eggs

(2010) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oocyte development in bovine primordial follicles is promoted by activin and FSH within a two-step serum-free culture system

(2010) Marie McLaughlin et al.   REPRODUCTION

Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles

(2009) Deepak Adhikari et al.   ENDOCRINE REVIEWS

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

(2009) D. Adhikari et al.   HUMAN MOLECULAR GENETICS

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles

(2009) Pradeep Reddy et al.   HUMAN MOLECULAR GENETICS

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles

(2009) D. Adhikari et al.   MOLECULAR HUMAN REPRODUCTION

Mechanisms maintaining the dormancy and survival of mammalian primordial follicles

(2009) Pradeep Reddy et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth

(2008) George B. John et al.   DEVELOPMENTAL BIOLOGY

A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin

(2008) E. E. Telfer et al.   HUMAN REPRODUCTION

Targeted Disruption ofPtenin Ovarian Granulosa Cells Enhances Ovulation and Extends the Life Span of Luteal Cells

(2008) Heng-Yu Fan et al.   MOLECULAR ENDOCRINOLOGY

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE

Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression

(2007) Shiona M. Coutts et al.   DEVELOPMENTAL BIOLOGY