Rapamycin-sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary

Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression

(2013) Xing-mei Zhang et al.   GENE

Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells

(2013) J. Perez-Sanz et al.   HUMAN REPRODUCTION

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling

(2013) Deepak Adhikari et al.   PLoS One

Ovarian Toxicity from Sirolimus

(2012) Matthias Braun et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Safe Use of a PTEN Inhibitor for the Activation of Dormant Mouse Primordial Follicles and Generation of Fertilizable Eggs

(2012) Deepak Adhikari et al.   PLoS One

The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion

(2012) J B Kerr et al.   REPRODUCTION

Transcriptional Control of Cellular Metabolism by mTOR Signaling

(2011) J. L. Yecies et al.   CANCER RESEARCH

Deletion of Tuberous Sclerosis 1 in Somatic Cells of the Murine Reproductive Tract Causes Female Infertility

(2011) Yoshihiro Tanaka et al.   ENDOCRINOLOGY

mTOR kinase inhibition results in oocyte loss characterized by empty follicles in human ovarian cortical strips cultured in vitro

(2011) Marie McLaughlin et al.   FERTILITY AND STERILITY

Oogenesis: Transcriptional regulators and mouse models

(2011) Krishna Jagarlamudi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Separase Phosphosite Mutation Leads to Genome Instability and Primordial Germ Cell Depletion during Oogenesis

(2011) Juan Xu et al.   PLoS One

mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation

(2011) James Yu et al.   PLoS One

Regulation of Interleukin-10 Receptor Ubiquitination and Stability by Beta-TrCP-Containing Ubiquitin E3 Ligase

(2011) Hui Jiang et al.   PLoS One

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

(2011) K. Selesniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational control of cyclins

(2011) Woan-Yuh Tarn et al.   Cell Division

p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies

(2010) S. A. Wander et al.   CLINICAL CANCER RESEARCH

p27Kip1 Negatively Regulates the Activation of Murine Primordial Oocytes

(2010) Yumiko HIRASHIMA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Primary ovarian insufficiency

(2010) Michel De Vos et al.   LANCET

Activation of dormant ovarian follicles to generate mature eggs

(2010) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation

(2009) George B. John et al.   DEVELOPMENTAL BIOLOGY

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

(2009) D. Adhikari et al.   HUMAN MOLECULAR GENETICS

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles

(2009) Pradeep Reddy et al.   HUMAN MOLECULAR GENETICS

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles

(2009) D. Adhikari et al.   MOLECULAR HUMAN REPRODUCTION

The primordial pool of follicles and nest breakdown in mammalian ovaries

(2009) C. Tingen et al.   MOLECULAR HUMAN REPRODUCTION

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age

(2008) Kaisa Selesniemi et al.   AGING CELL

GCN2 activation and eIF2α phosphorylation in the maturation of mouse oocytes

(2008) Viviane S. Alves et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Germ Cell-Specific Transcriptional Regulator Sohlh2 Is Essential for Early Mouse Folliculogenesis and Oocyte-Specific Gene Expression1

(2008) Youngsok Choi et al.   BIOLOGY OF REPRODUCTION

Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth

(2008) George B. John et al.   DEVELOPMENTAL BIOLOGY

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation

(2008) Feng Hong et al.   MOLECULAR CELL

Targeted Disruption ofPtenin Ovarian Granulosa Cells Enhances Ovulation and Extends the Life Span of Luteal Cells

(2008) Heng-Yu Fan et al.   MOLECULAR ENDOCRINOLOGY

Awakening the oocyte: controlling primordial follicle development

(2008) Eileen A McLaughlin et al.   REPRODUCTION

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE

Identification of CDK2 substrates in human cell lysates

(2008) Yong Chi et al.   GENOME BIOLOGY