Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases

Concomitant suppression of T H 2 and T H 17 cell responses in allergic asthma by targeting retinoic acid receptor–related orphan receptor γt

(2018) Hyeongjin Na et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Retinoic Acid Enhances Apolipoprotein E Synthesis in Human Macrophages

(2018) Vera Clemens et al.   JOURNAL OF ALZHEIMERS DISEASE

Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease

(2018) Taekil Eom et al.   JOURNAL OF MICROBIOLOGY

Photoaging and skin cancer: Is the inflammasome the missing link?

(2018) Fawaz Awad et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

(2018) Patrice D. Cani et al.   Nature Reviews Gastroenterology & Hepatology

Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain

(2018) Marta Machado-Pereira et al.   NEUROSCIENCE LETTERS

Orobanche cernua Loefling Attenuates Ultraviolet B-mediated Photoaging in Human Dermal Fibroblasts

(2018) Wei Gao et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Cooperative Therapeutic Action of Retinoic Acid Receptor and Retinoid X Receptor Agonists in a Mouse Model of Alzheimer's Disease

(2018) Kohichi Kawahara et al.   JOURNAL OF ALZHEIMERS DISEASE

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production

(2017) Elise Dalmas et al.   IMMUNITY

Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects

(2017) Samar Khalil et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Differential regulation of CD103 (αE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands

(2017) Mandi M. Roe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

All- trans -retinoic acid represses chemokine expression in adipocytes and adipose tissue by inhibiting NF-κB signaling

(2017) Esma Karkeni et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles

(2017) Marta Machado-Pereira et al.   MEDIATORS OF INFLAMMATION

All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-αand Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer

(2017) Hayet Rafa et al.   MEDIATORS OF INFLAMMATION

Retinoic Acid and Immune Homeostasis: A Balancing Act

(2017) Martje N. Erkelens et al.   TRENDS IN IMMUNOLOGY

Retinoic acid pre-treatment down regulates V. cholerae outer membrane vesicles induced acute inflammation and enhances mucosal immunity

(2017) Ritam Sinha et al.   VACCINE

Retinoic Acid and Its Role in Modulating Intestinal Innate Immunity

(2017) Paulo Czarnewski et al.   Nutrients

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

(2017) Matthew J. Stebbins et al.   Biotechnology Journal

Synchronizing pharmacotherapy in acne with review of clinical care

(2017) SarvajnamurthyAradhya Sacchidanand et al.   INDIAN JOURNAL OF DERMATOLOGY

Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors

(2017) Bo Wang et al.   Cell Discovery

Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

(2016) Ryan R. Riahi et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Vitamin A maintains the airway epithelium in a murine model of asthma by suppressing glucocorticoid-induced leucine zipper

(2016) C. Niu et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 + T Cell-Mediated Immunity in Colorectal Cancer

(2016) Nupur Bhattacharya et al.   IMMUNITY

Retinoic acid decreases the severity of Salmonella enterica serovar Typhimurium mediated gastroenteritis in a mouse model

(2016) Ritam Sinha et al.   IMMUNOBIOLOGY

Retinoic acid suppresses IL-17 production and pathogenic activity of γδ T cells in CNS autoimmunity

(2016) Mathilde Raverdeau et al.   IMMUNOLOGY AND CELL BIOLOGY

Vitamin A Deficiency Promotes Inflammation by Induction of Type 2 Cytokines in Experimental Ovalbumin-Induced Asthma Murine Model

(2016) Weiwei Cui et al.   INFLAMMATION

Human innate lymphoid cells

(2016) Jenny Mjösberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Vitamin A Controls the Presence of RORγ+Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine

(2016) Gera Goverse et al.   JOURNAL OF IMMUNOLOGY

Retinyl Palmitate Supplementation Modulates T-bet and Interferon Gamma Gene Expression in Multiple Sclerosis Patients

(2016) Niyaz Mohammadzadeh Honarvar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats

(2016) Nassima Behairi et al.   JOURNAL OF NEUROIMMUNOLOGY

All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus in an Alzheimer's mouse model

(2016) Risa Takamura et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway

(2016) Ying Zhou et al.   KIDNEY & BLOOD PRESSURE RESEARCH

The effect of 1, 25(OH)2 D3 (calcitriol) alone and in combination with all-trans retinoic acid on ROR-γt, IL-17, TGF-β, and FOXP3 gene expression in experimental autoimmune encephalomyelitis

(2016) Karim Parastouei et al.   NUTRITIONAL NEUROSCIENCE

Topical Therapies for Psoriasis: Improving Management Strategies and Patient Adherence

(2016)   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Retinoic Acid as a Modulator of T Cell Immunity

(2016) Maria Bono et al.   Nutrients

Retinoic acid facilitates inactivated transmissible gastroenteritis virus induction of CD8+ T-cell migration to the porcine gut

(2016) Xiaojuan Chen et al.   Scientific Reports

Vitamin A Inhibits Development of Dextran Sulfate Sodium-Induced Colitis and Colon Cancer in a Mouse Model

(2016) Isao Okayasu et al.   Biomed Research International

Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice

(2016) H. L. Penny et al.   Cancer Immunology Research

Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together

(2016) Gareth W. Jones et al.   Frontiers in Immunology

All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages

(2016) Victor W. Ho et al.   PLoS One

Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells

(2015) B. Ruiter et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program

(2015) Chrysothemis C. Brown et al.   IMMUNITY

Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut

(2015) Myung H. Kim et al.   IMMUNITY

Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

(2015) Jochem H. Bernink et al.   IMMUNITY

The Effects of All-Trans Retinoic Acid on the Induction of Oral Tolerance in a Murine Model of Bronchial Asthma

(2015) Hirotaka Sakamoto et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

IRF4 Is a Critical Gene in Retinoic Acid–Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency–Derived B Cells

(2015) Randi L. Indrevær et al.   JOURNAL OF IMMUNOLOGY

The Effect of Vitamin A Supplementation on FoxP3 and TGF-β Gene Expression in Avonex-Treated Multiple Sclerosis Patients

(2015) Ali Akbar Saboor-Yaraghi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

All-trans-Retinoic Acid Modulates Nitric Oxide and Interleukin-17A Production by Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease

(2015) Nassima Behairi et al.   NEUROIMMUNOMODULATION

High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test

(2015) Márcia Soares-Mota   WORLD JOURNAL OF GASTROENTEROLOGY

Effect of Retinoic Acid in a Mouse Model of Allergic Rhinitis

(2015) Hye-Lim Son et al.   Allergy Asthma & Immunology Research

Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation

(2015) Gabriela Tejón et al.   Biomed Research International

Obesity, inflammation, and the gut microbiota

(2015) Amanda J Cox et al.   Lancet Diabetes & Endocrinology

NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

(2015) Wei Wang   Frontiers in Immunology

Lactoferrin Combined with Retinoic Acid Stimulates B1 Cells to Express IgA Isotype and Gut-homing Molecules

(2015) Seong-Ho Kang et al.   Immune Network

Astrocyte-derived retinoic acid: a novel regulator of blood–brain barrier function in multiple sclerosis

(2014) Mark R. Mizee et al.   ACTA NEUROPATHOLOGICA

Experimental immunology Decreased serum and mucosa immunoglobulin A levels in vitamin A- and zinc-deficient mice

(2014) Sorayya Kheirouri et al.   Central European Journal of Immunology

All-trans retinoic acid attenuates experimental colitis through inhibition of NF-κB signaling

(2014) Kai Hong et al.   IMMUNOLOGY LETTERS

Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

(2014) Max Leenders et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatocyte Nuclear Factor 4α (HNF4α) in Coordination With Retinoic Acid Receptors Increasesall-trans-Retinoic Acid-Dependent CYP26A1 Gene Expression in HepG2 Human Hepatocytes

(2014) Reza Zolfaghari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Vitamin A Deficiency Decreases and High Dietary Vitamin A Increases Disease Severity in the Mouse Model of Asthma

(2014) G. U. Schuster et al.   JOURNAL OF IMMUNOLOGY

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

(2014) G Bakdash et al.   Mucosal Immunology

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

(2014) Serge A. van de Pavert et al.   NATURE

Intestinal macrophages and dendritic cells: what's the difference?

(2014) Vuk Cerovic et al.   TRENDS IN IMMUNOLOGY

Oral retinyl palmitate or retinoic acid corrects mucosal IgA responses toward an intranasal influenza virus vaccine in vitamin A deficient mice

(2014) S.L. Surman et al.   VACCINE

All-trans retinoic acid attenuates airway inflammation by inhibiting Th2 and Th17 response in experimental allergic asthma

(2013) Jinhong Wu et al.   BMC IMMUNOLOGY

Synergistic effects of atorvastatin and all-trans retinoic acid in ameliorating animal model of multiple sclerosis

(2013) Seyyed Meysam Abtahi Froushani et al.   IMMUNOLOGICAL INVESTIGATIONS

Vitamin A and dendritic cell differentiation

(2013) Marieke R. Beijer et al.   IMMUNOLOGY

The STRA6 Receptor Is Essential for Retinol-binding Protein-induced Insulin Resistance but Not for Maintaining Vitamin A Homeostasis in Tissues Other Than the Eye

(2013) Daniel C. Berry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation

(2013) Lisa A. Mielke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract

(2013) Darren Ruane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

(2013) William R Heath et al.   NATURE IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

The Retinoic Acid-Metabolizing Enzyme Cyp26b1 Regulates CD4 T Cell Differentiation and Function

(2013) Alistair Chenery et al.   PLoS One

Diversity, function, and transcriptional regulation of gut innate lymphocytes

(2013) Lucille Rankin et al.   Frontiers in Oncology

Innate Lymphoid Cells: Balancing Immunity, Inflammation, and Tissue Repair in the Intestine

(2012) Elia D. Tait Wojno et al.   Cell Host & Microbe

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

(2012) Leslie L Muldoon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systemic Isotretinoin Therapy Normalizes Exaggerated TLR-2-Mediated Innate Immune Responses in Acne Patients

(2012) Melanie C. Dispenza et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transthyretin Blocks Retinol Uptake and Cell Signaling by the Holo-Retinol-Binding Protein Receptor STRA6

(2012) D. C. Berry et al.   MOLECULAR AND CELLULAR BIOLOGY

Retinoic Acid Attenuates Ileitis by Restoring the Balance Between T-Helper 17 and T Regulatory Cells

(2011) Colm B. Collins et al.   GASTROENTEROLOGY

Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha

(2011) Jason A. Hall et al.   IMMUNITY

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice

(2011) Swantje I. Hammerschmidt et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostaglandin E2 suppresses the differentiation of retinoic acid–producing dendritic cells in mice and humans

(2011) Angus Stock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A retinoic acid–dependent checkpoint in the development of CD4+T cell–mediated immunity

(2011) Karina Pino-Lagos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of Retinaldehyde Dehydrogenase Enzymes in Mucosal Dendritic Cells and Gut-Draining Lymph Node Stromal Cells Is Controlled by Dietary Vitamin A

(2011) R. Molenaar et al.   JOURNAL OF IMMUNOLOGY

A sensitive and specific method for measurement of multiple retinoids in human serum with UHPLC-MS/MS

(2011) Samuel L. M. Arnold et al.   JOURNAL OF LIPID RESEARCH

Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance

(2011) Barbara Cassani et al.   MOLECULAR ASPECTS OF MEDICINE

Cyp26b1 Regulates Retinoic Acid-Dependent Signals in T Cells and Its Expression Is Inhibited by Transforming Growth Factor-β

(2011) Hajime Takeuchi et al.   PLoS One

Langerhans cells are precommitted to immune tolerance induction

(2011) E. Shklovskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis

(2011) F. Jadidi-Niaragh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation

(2011) C. Moore et al.   TRANSPLANTATION PROCEEDINGS

How vitamin A metabolizing dendritic cells are generated in the gut mucosa

(2011) William W. Agace et al.   TRENDS IN IMMUNOLOGY

Skin-draining lymph nodes contain dermis-derived CD103- dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells

(2010) M. Guilliams et al.   BLOOD

Retinoic Acid Treatment Enhances Lipid Oxidation and Inhibits Lipid Biosynthesis Capacities in the Liver of Mice

(2010) Jaume Amengual et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis

(2010) Karima R.R. Siddiqui et al.   IMMUNITY

The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut

(2010) Keiichiro Suzuki et al.   IMMUNITY

Retinoic Acid Determines the Precise Tissue Tropism of Inflammatory Th17 Cells in the Intestine

(2010) C. Wang et al.   JOURNAL OF IMMUNOLOGY

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid

(2010) Sabien van Neerven et al.   JOURNAL OF NEUROIMMUNOLOGY

Vitamin A as a Regulator of Antigen Presenting Cells

(2010) David M. Duriancik et al.   JOURNAL OF NUTRITION

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

(2010) Hergen Spits et al.   NATURE IMMUNOLOGY

Control systems and decision making for antibody production

(2010) Christopher C Goodnow et al.   NATURE IMMUNOLOGY

Nutritional roles of lactoferrin

(2009) Bo Lönnerdal   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Gut Homing Receptors on CD8 T Cells Are Retinoic Acid Dependent and Not Maintained by Liver Dendritic or Stellate Cells

(2009) Bertus Eksteen et al.   GASTROENTEROLOGY

GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity

(2009) Aya Yokota et al.   INTERNATIONAL IMMUNOLOGY

Serum Vitamin A and β-Carotene Levels in Children with Asthma

(2009) Abdulrahman M. Al Senaidy   JOURNAL OF ASTHMA

All-trans-Retinoic Acid Represses Obesity and Insulin Resistance by Activating both Peroxisome Proliferation-Activated Receptor  /  and Retinoic Acid Receptor

(2009) D. C. Berry et al.   MOLECULAR AND CELLULAR BIOLOGY

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma

(2009) Sangeeta Goswami et al.   NATURE IMMUNOLOGY

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis

(2009) S Allen et al.   THORAX

Vitamin A regulates obesity in WNIN/Ob obese rat; independent of stearoyl-CoA desaturase-1

(2008) S.M. Jeyakumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Retinoic acid signaling in development: Tissue-specific functions and evolutionary origins

(2008) Florent Campo-Paysaa et al.   GENESIS

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

(2008) Jonathan A. Hill et al.   IMMUNITY

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Markers of Innate Immune Function Are Associated with Vitamin A Stores in Men

(2008) Shaikh M. Ahmad et al.   JOURNAL OF NUTRITION

CD103+ GALT DCs promote Foxp3+ regulatory T cells

(2008) K R R Siddiqui et al.   Mucosal Immunology

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated Receptor

(2008) Schoen W Kruse et al.   PLOS BIOLOGY