Overlapping and distinct features of viral and allergen immunity in the human lung

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

(2021) Jack Gisby et al.   eLife

MAIT Cells in Health and Disease

(2020) Nicholas M. Provine et al.   Annual Review of Immunology

Dynamics of human monocytes and airway macrophages during healthy aging and after transplant

(2020) Adam J. Byrne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

(2020) Cedric Bosteels et al.   IMMUNITY

Respiratory microbiome and epithelial interactions shape immunity in the lungs

(2020) Rachele Invernizzi et al.   IMMUNOLOGY

Human Th1 and Th2 Cells Targeting Rhinovirus and Allergen Coordinately Promote Allergic Asthma.

(2020) Lyndsey M. Muehling et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Helper-like Innate Lymphoid Cells in Humans and Mice

(2020) Sophie Guia et al.   TRENDS IN IMMUNOLOGY

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties

(2020) Basak B. Ural et al.   Science Immunology

A Single-cell Atlas of the Human Healthy Airways

(2020) Marie Deprez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease

(2020) Rod A. Rahimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

(2020) Abigail Vanderheiden et al.   JOURNAL OF VIROLOGY

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity

(2020) Ursula Smole et al.   NATURE IMMUNOLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

(2020) Jack Major et al.   SCIENCE

Type III interferons disrupt the lung epithelial barrier upon viral recognition

(2020) Achille Broggi et al.   SCIENCE

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

(2020) Zhixuan Loh et al.   PLoS Pathogens

Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma

(2020) Grégory Seumois et al.   Science Immunology

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

(2020) Daniela Weiskopf et al.   Science Immunology

The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease

(2020) Timothy N. Perkins et al.   ALLERGY

MAIT Cell Development and Functions: the Microbial Connection

(2020) François Legoux et al.   IMMUNITY

Unbiased screens show CD8+ T cells of COVID-19 patients recognize shared epitopes in SARS-CoV-2, most of which are not located in the Spike protein

(2020) Andrew P. Ferretti et al.   IMMUNITY

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection

(2020) Maximillian S. Habibi et al.   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Natural killer cell immunotypes related to COVID-19 disease severity

(2020) Christopher Maucourant et al.   Science Immunology

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

(2020) Elizabeth R. Mann et al.   Science Immunology

Systemic and respiratory T-cells induced by seasonal H1N1 influenza protect against pandemic H2N2 in ferrets

(2020) Koen van de Ven et al.   Communications Biology

Genetic mechanisms of critical illness in Covid-19

(2020) Erola Pairo-Castineira et al.   NATURE

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Phillip D Monk et al.   Lancet Respiratory Medicine

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

(2019) Amy H. Lee et al.   Nature Communications

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

(2019) Marios Koutsakos et al.   NATURE IMMUNOLOGY

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

(2019) Madelene W. Dahlgren et al.   IMMUNITY

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease

(2019) Herbert B Schiller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Elevated Levels of Type 2 Respiratory Innate Lymphoid Cells in Human Infants with Severe RSV Bronchiolitis

(2019) Luan D. Vu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary type2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids

(2019) Prasad Nagakumar et al.   EUROPEAN RESPIRATORY JOURNAL

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells

(2019) Christopher Andrew Tibbitt et al.   IMMUNITY

Regulatory roles of IL-10–producing human follicular T cells

(2019) Pablo F. Cañete et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Severe influenza pneumonitis in children with inherited TLR3 deficiency

(2019) Hye Kyung Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A cellular census of human lungs identifies novel cell states in health and in asthma

(2019) Felipe A. Vieira Braga et al.   NATURE MEDICINE

Identification of a T follicular helper cell subset that drives anaphylactic IgE

(2019) Uthaman Gowthaman et al.   SCIENCE

Laboratory mice born to wild mice have natural microbiota and model human immune responses

(2019) Stephan P. Rosshart et al.   SCIENCE

Th2-TRMs Maintain Life-Long Allergic Memory in Experimental Asthma in Mice

(2019) Berislav Bošnjak et al.   Frontiers in Immunology

Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells

(2019) Marlena Scharenberg et al.   Frontiers in Immunology

Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans

(2019) Franz Puttur et al.   Science Immunology

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

(2019) Adriana Forero et al.   IMMUNITY

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1

(2019) Irene Ramos et al.   JOURNAL OF VIROLOGY

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

(2019) Rachel L. Clement et al.   NATURE IMMUNOLOGY

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

(2019) Timothy S.C. Hinks et al.   Cell Reports

CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

(2019) Tomomi Ichikawa et al.   NATURE IMMUNOLOGY

Enhanced frequency and function of follicular T cells in the tonsils of house dust mite‐sensitized children

(2019) William S. Foster et al.   ALLERGY

Mucosal-associated invariant T cells restrict allergic airway inflammation

(2019) Longyun Ye et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection

(2019) Aleks Guvenel et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytokine Responses to Rhinovirus and Development of Asthma, Allergic Sensitization, and Respiratory Infections during Childhood

(2018) Adnan Custovic et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reduced Nasal Viral Load and IFN Responses in Infants with RSV Bronchiolitis and Respiratory Failure

(2018) Ryan S Thwaites et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis

(2018) Yuki Morimoto et al.   IMMUNITY

Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment

(2018) Shilpi Chandra et al.   JOURNAL OF IMMUNOLOGY

The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca 2+ Channels and Mast Cell Migration through PAR4 Receptors

(2018) Yu-Ping Lin et al.   MOLECULAR CELL

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

(2018) Mario Castro et al.   NEW ENGLAND JOURNAL OF MEDICINE

IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

(2018) Jonas Klinkhammer et al.   eLife

Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing

(2018) Yael Steuerman et al.   Cell Systems

Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease

(2018) Faith. I. Uwadiae et al.   ALLERGY

Stereotypic Immune System Development in Newborn Children

(2018) Axel Olin et al.   CELL

Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity

(2018) Xi-zhi J. Guo et al.   IMMUNITY

Role of CD1d- and MR1-Restricted T Cells in Asthma

(2018) Chiaki Iwamura et al.   Frontiers in Immunology

High-mobility group box-1 protein from CC10+ club cells promotes type 2 response in the later stage of respiratory syncytial virus infection

(2018) Sisi Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity

(2018) Lara Ravanetti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

MAIT cells contribute to protection against lethal influenza infection in vivo

(2018) Bonnie van Wilgenburg et al.   Nature Communications

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion

(2017) Carlos M. Minutti et al.   IMMUNITY

Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

(2017) Julie Deckers et al.   IMMUNOLOGICAL REVIEWS

Follicular helper T cells mediate IgE antibody response to airborne allergens

(2017) Takao Kobayashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69 − CD56 dim cells

(2017) Nicole Marquardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis

(2017) María Luz García-García et al.   MEDICINE

Trigger-happy resident memory CD4+ T cells inhabit the human lungs

(2017) A E Oja et al.   Mucosal Immunology

IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells

(2017) D Califano et al.   Mucosal Immunology

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders

(2017) Erik Wambre et al.   Science Translational Medicine

The comparative immunology of wild and laboratory mice, Mus musculus domesticus

(2017) Stephen Abolins et al.   Nature Communications

Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre

(2017) Victoria M. W. Gould et al.   Frontiers in Microbiology

A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13)

(2017) Trevor T. Hansel et al.   EBioMedicine

T follicular helper (Tfh) cells in normal immune responses and in allergic disorders

(2016) G. Varricchi et al.   ALLERGY

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures

(2016) Michael Thomas Wong et al.   IMMUNITY

Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma

(2016) Brian D. Hondowicz et al.   IMMUNITY

Type 2 innate lymphoid cells in induced sputum from children with severe asthma

(2016) Prasad Nagakumar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

(2016) Ai Ing Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of an atypical monocyte and committed progenitor involved in fibrosis

(2016) Takashi Satoh et al.   NATURE

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

IL-33polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort

(2016) Paul C. Schröder et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis

(2016) Aoife Kerrin et al.   THORAX

MAIT cells are activated during human viral infections

(2016) Bonnie van Wilgenburg et al.   Nature Communications

Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes

(2016) Olga Lourenço et al.   Frontiers in Immunology

Cigarette Smoke Decreases the Maturation of Lung Myeloid Dendritic Cells

(2016) Elena Arellano-Orden et al.   PLoS One

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

(2015) Maximillian S. Habibi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Asthma phenotypes and IgE responses

(2015) Antoine Froidure et al.   EUROPEAN RESPIRATORY JOURNAL

Allergen-induced airway responses

(2015) Gail M. Gauvreau et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

(2015) Laura Denney et al.   IMMUNITY

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33

(2015) Christina A. Christianson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33

(2015) Susana Castanhinha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

(2015) Timothy S.C. Hinks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

(2015) Claudia U Duerr et al.   NATURE IMMUNOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

Respiratory epithelial cells orchestrate pulmonary innate immunity

(2015) Jeffrey A Whitsett et al.   NATURE IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

(2015) G. Gasteiger et al.   SCIENCE

Pulmonary macrophages: key players in the innate defence of the airways

(2015) Adam J Byrne et al.   THORAX

RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

(2015) Agnieszka Jozwik et al.   Nature Communications

Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33

(2015) Jordy Saravia et al.   PLoS Pathogens

Airway Epithelium Interactions with Aeroallergens: Role of Secreted Cytokines and Chemokines in Innate Immunity

(2015) Vivek D. Gandhi et al.   Frontiers in Immunology

IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma ExacerbationsIn Vivo

(2014) David J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

Rhinovirus infection in young children is associated with elevated airway TSLP levels

(2014) G. F. Perez et al.   EUROPEAN RESPIRATORY JOURNAL

Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma

(2014) Chaoyu Irvin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

(2014) Gail M. Gauvreau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

(2014) J. Beale et al.   Science Translational Medicine

Transcriptomic Characterization of the Novel Avian-Origin Influenza A (H7N9) Virus: Specific Host Response and Responses Intermediate between Avian (H5N1 and H7N7) and Human (H3N2) Viruses and Implications for Treatment Options

(2014) L. Josset et al.   mBio

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

(2014) V. D. Menachery et al.   mBio

Control of Human Viral Infections by Natural Killer Cells

(2013) Stephanie Jost et al.   Annual Review of Immunology

IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma

(2013) Sejal Saglani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma

(2013) Takashi Kinoshita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Delayed Sequelae of Neonatal Respiratory Syncytial Virus Infection Are Dependent on Cells of the Innate Immune System

(2013) J. A. Harker et al.   JOURNAL OF VIROLOGY

Lung niches for the generation and maintenance of tissue-resident memory T cells

(2013) D L Turner et al.   Mucosal Immunology

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

(2013) David A Hinds et al.   NATURE GENETICS

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

Lung Dendritic Cells in Respiratory Viral Infection and Asthma: From Protection to Immunopathology

(2012) Bart N. Lambrecht et al.   Annual Review of Immunology

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Plasma levels of soluble MICA and ULBP2 are increased in children allergic to dust mites

(2012) Giulia Matusali et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Alveolar Macrophages Are a Major Determinant of Early Responses to Viral Lung Infection but Do Not Influence Subsequent Disease Development

(2008) P. K. Pribul et al.   JOURNAL OF VIROLOGY