Circulating Calprotectin as a Biomarker of COVID-19 Severity

EULAR points to consider on pathophysiology and use of immunomodulatory therapies in COVID-19

(2021) Alessia Alunno et al.   ANNALS OF THE RHEUMATIC DISEASES

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

(2021) Xianwen Ren et al.   CELL

Critical role of pre-analytical aspects for the measurement of circulating calprotectin in serum or plasma as a biomarker for neutrophil-related inflammation

(2021) Maria Infantino et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Calprotectin, an Emerging Biomarker of Interest in COVID-19: A Systematic Review and Meta-Analysis

(2021) Raphael Udeh et al.   Journal of Clinical Medicine

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

(2020) Stephen A. Lauer et al.   ANNALS OF INTERNAL MEDICINE

Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry

(2020) Milena Gianfrancesco et al.   ANNALS OF THE RHEUMATIC DISEASES

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

(2020) Xiaohua Chen et al.   CLINICAL INFECTIOUS DISEASES

IL-6: Relevance for immunopathology of SARS-CoV-2

(2020) E.O. Gubernatorova et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Fecal Calprotectin and RT-PCR from both nasopharyngeal swab and stool samples prior to treatment decision in IBD patients during CoVID-19 outbreak.

(2020) Dr Cherradi Younes   DIGESTIVE AND LIVER DISEASE

COVID-19 and gastrointestinal endoscopies: current insights and emergent strategies

(2020) Abhilash Perisetti et al.   Digestive Endoscopy

Fecal calprotectin

(2020) Lorenzo Bertani et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Tocilizumab for severe COVID-19: A promising intervention affecting inflammation and coagulation

(2020) Marcel Levi   European Journal of Internal Medicine

Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study

(2020) Corrado Campochiaro et al.   European Journal of Internal Medicine

The utility of fecal calprotectin in the era of COVID-19 pandemic

(2020) Sheena Mago et al.   GASTROENTEROLOGY

Faecal calprotectin indicates intestinal inflammation in COVID-19

(2020) Maria Effenberger et al.   GUT

Complement activation in patients with COVID-19: A novel therapeutic target

(2020) Massimo Cugno et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

COVID‐19: Consider IL6 receptor antagonist for the therapy of cytokine storm syndrome in SARS‐CoV‐2 infected patients

(2020) Chiranjib Chakraborty et al.   JOURNAL OF MEDICAL VIROLOGY

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed

(2020) Marc Feldmann et al.   LANCET

Novel therapeutic targets for SARS-CoV-2-induced acute lung injury: targeting a potential IL-1β/Neutrophil Extracellular Traps feedback loop

(2020) Ahmed Yaqinuddin et al.   MEDICAL HYPOTHESES

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?

(2020) Ulf Andersson et al.   MOLECULAR MEDICINE

Miller Fisher Syndrome and polyneuritis cranialis in COVID-19

(2020) Consuelo Gutiérrez-Ortiz et al.   NEUROLOGY

Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19

(2020) Louise Bowles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

(2020) Yan Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Laboratory testing of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 (2019‐nCoV): Current status, challenges, and countermeasures

(2020) Ying Yan et al.   REVIEWS IN MEDICAL VIROLOGY

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19

(2020) Wenhua Liang et al.   JAMA Internal Medicine

COVID-19 Global Rheumatology Alliance Registry, anti-IL-6 therapy, shared decision-making and patient outcomes. Response to: ‘Correspondence on ‘Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry’ by Gianfrancesco et al. Compassionate use of tocilizumab in severe COVID-19 with hyperinflammation prior to advent of clinical trials – a real-world district general hospital experience’ by Khan et al, ‘Comment on ‘Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 global rheumatology alliance physician-reported registry’ by Gianfrancesco M et al’ by Andreica et al and ‘COVID-19 outcomes in patients with systemic autoimmune diseases treated with immunomodulatory drugs’ by Ansarin et al

(2020) Milena Gianfrancesco et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoantibodies related to systemic autoimmune rheumatic diseases in severely ill patients with COVID-19

(2020) Panayiotis G Vlachoyiannopoulos et al.   ANNALS OF THE RHEUMATIC DISEASES

Serological tests confirm the low incidence of COVID-19 in chronic rheumatic inflammatory diseases treated with biological DMARD

(2020) Maurizio Benucci et al.   ANNALS OF THE RHEUMATIC DISEASES

Response to: ‘Similarities and differences between severe COVID-19 pneumonia and anti-MDA-5 positive dermatomyositis associated rapidly progressive interstitial lung diseases: a challenge for the future’ by Wang et al

(2020) Janine A Lamb et al.   ANNALS OF THE RHEUMATIC DISEASES

Covid-19 and autoimmunity

(2020) Michael Ehrenfeld et al.   AUTOIMMUNITY REVIEWS

Potential Role of Anti-interleukin (IL)-6 Drugs in the Treatment of COVID-19: Rationale, Clinical Evidence and Risks

(2020) Salvatore Crisafulli et al.   BIODRUGS

Tackling COVID‐19 infection through complement‐targeted immunotherapy

(2020) Sonata Jodele et al.   BRITISH JOURNAL OF PHARMACOLOGY

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

(2020) Aymeric Silvin et al.   CELL

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

(2020) Liting Chen et al.   Cellular & Molecular Immunology

Putative Mechanisms of Diarrhea in COVID-19

(2020) Abhilash Perisetti et al.   Clinical Gastroenterology and Hepatology

Antibody-dependent enhancement and COVID-19: Moving toward acquittal

(2020) Eric J. Yager   CLINICAL IMMUNOLOGY

Patients with COVID-19 present with low plasma citrulline concentrations that associate with systemic inflammation and gastrointestinal symptoms

(2020) Mathieu Uzzan et al.   DIGESTIVE AND LIVER DISEASE

COVID-19 EXTRAPULMONARY ILLNESS – SPECIAL GASTROINTESTINAL AND HEPATIC CONSIDERATIONS

(2020) R.B. McFee   DM DISEASE-A-MONTH

Miller‐Fisher syndrome after COVID‐19: neurochemical markers as an early sign of nervous system involvement

(2020) Makbule Senel et al.   EUROPEAN JOURNAL OF NEUROLOGY

Guillain‐Barré syndrome in a patient with antibodies against SARS‐COV‐2

(2020) Raimund Helbok et al.   EUROPEAN JOURNAL OF NEUROLOGY

Comparison of severity scores for COVID-19 patients with pneumonia: a retrospective study

(2020) Guohui Fan et al.   EUROPEAN RESPIRATORY JOURNAL

Case report: use of lenzilumab and tocilizumab for the treatment of coronavirus disease 2019

(2020) Megan Melody et al.   Immunotherapy

COVID-19, coagulopathy and venous thromboembolism: more questions than answers

(2020) Marco Marietta et al.   Internal and Emergency Medicine

Changes of hematological and immunological parameters in COVID-19 patients

(2020) Xiaohong Yuan et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Autoinflammatory and autoimmune conditions at the crossroad of COVID-19

(2020) Yhojan Rodríguez et al.   JOURNAL OF AUTOIMMUNITY

Utilizing tocilizumab for the treatment of cytokine release syndrome in COVID-19

(2020) Ali Hassoun et al.   JOURNAL OF CLINICAL VIROLOGY

Circulating levels of GDF-15 and calprotectin for prediction of in-hospital mortality in COVID-19 patients: a case series

(2020) Luis García de GuadianaRomualdo et al.   JOURNAL OF INFECTION

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Impact of comorbidities on patients with COVID‐19: A large retrospective study in Zhejiang, China

(2020) Chanyuan Ye et al.   JOURNAL OF MEDICAL VIROLOGY

COVID‐19: What type of cytokine storm are we dealing with?

(2020) Guillaume Monneret et al.   JOURNAL OF MEDICAL VIROLOGY

Immune-mediated neurological syndromes in SARS-CoV-2-infected patients

(2020) Antoine Guilmot et al.   JOURNAL OF NEUROLOGY

SARS-CoV-2 associated Guillain–Barré syndrome

(2020) Teodor Pelea et al.   JOURNAL OF NEUROLOGY

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

(2020) Julien Carvelli et al.   NATURE

The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries

(2020) Michael C. Grant et al.   PLoS One

Real-life experience of tocilizumab use in COVID-19 patients

(2020) Anastasia-Vasiliki Madenidou et al.   RHEUMATOLOGY

Autoimmune and rheumatic musculoskeletal diseases as a consequence of SARS-CoV-2 infection and its treatment

(2020) Sanket Shah et al.   RHEUMATOLOGY INTERNATIONAL

A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial

(2020) Jonathan Rilinger et al.   Trials

Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial

(2020) Bastiaan Maes et al.   Trials

Association of viral load with serum biomakers among COVID-19 cases

(2020) Fengjuan Shi et al.   VIROLOGY

Is a “Cytokine Storm” Relevant to COVID-19?

(2020) Pratik Sinha et al.   JAMA Internal Medicine

Potential Treatments for COVID-19 Related Cytokine Storm - Beyond Corticosteroids

(2020) Yi Miao et al.   Frontiers in Immunology

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

(2020) Yujun Tang et al.   Frontiers in Immunology

Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper

(2020) Sonu Bhaskar et al.   Frontiers in Immunology

Guillain-Barré syndrome: The first documented COVID-19–triggered autoimmune neurologic disease

(2020) Marinos C. Dalakas   Neurology-Neuroimmunology & Neuroinflammation

Preliminary predictive criteria for COVID-19 cytokine storm

(2020) Roberto Caricchio et al.   ANNALS OF THE RHEUMATIC DISEASES

COVID‐19 and immunological dysregulation: can autoantibodies be useful?

(2020) Simona Pascolini et al.   CTS-Clinical and Translational Science

Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19

(2020) Ting Shu et al.   IMMUNITY

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

(2020) Panagiotis Skendros et al.   JOURNAL OF CLINICAL INVESTIGATION

Associations between serum amyloid A, interleukin‐6, and COVID‐19: A cross‐sectional study

(2020) Qian Liu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

(2020) Coraline Radermecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil calprotectin identifies severe pulmonary disease in COVID‐19

(2020) Hui Shi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Development and validation of a simplified nomogram predicting individual critical illness of risk in COVID‐19: A retrospective study

(2020) Ranran Xu et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical laboratory characteristics in patients with suspected COVID‐19: One single‐institution experience

(2020) Fei Fei et al.   JOURNAL OF MEDICAL VIROLOGY

Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series

(2020) Andrew G. Weber et al.   MOLECULAR MEDICINE

Transcriptional and proteomic insights into the host response in fatal COVID-19 cases

(2020) Meng Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

(2020) Jan C. Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Liver Function Test Abnormalities Are Associated With A Poorer Prognosis In Covid-19 Patients: Results Of A French Cohort

(2020) Sayma Chaibi et al.   Clinics and Research in Hepatology and Gastroenterology

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome

(2020) Maria Orietta Borghi et al.   Frontiers in Immunology

Setting up a Virtual Calprotectin Clinic in Inflammatory Bowel Diseases: Literature Review and Nancy Experience

(2020) Ferdinando D’Amico et al.   Journal of Clinical Medicine

Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs

(2020) Lorenzo Gamberini et al.   Journal of Intensive Care

Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic

(2020) Jeffrey R Strich et al.   JOURNAL OF INFECTIOUS DISEASES

Joint prediction and time estimation of COVID-19 developing severe symptoms using chest CT scan

(2020) Xiaofeng Zhu et al.   MEDICAL IMAGE ANALYSIS

Biomarkers for the prediction of venous thromboembolism in critically ill COVID-19 patients

(2020) Romein W.G. Dujardin et al.   THROMBOSIS RESEARCH

Assessment of Neutrophil Extracellular Traps in Coronary Thrombus of a Case Series of Patients With COVID-19 and Myocardial Infarction

(2020) Ana Blasco et al.   JAMA Cardiology

An immune-based biomarker signature is associated with mortality in COVID-19 patients

(2020) Michael S. Abers et al.   JCI Insight

Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency department

(2020) Wolfgang Bauer et al.   JOURNAL OF INFECTION

Troponin and Other Biomarker Levels and Outcomes Among Patients Hospitalized With COVID‐19: Derivation and Validation of the HA 2 T 2 COVID‐19 Mortality Risk Score

(2020) Kevin K. Manocha et al.   Journal of the American Heart Association

Anakinra, una alternativa potencial en el tratamiento de la infección respiratoria grave por SARS-CoV-2 refractaria a tocilizumab

(2020) Luis Figuero-Pérez et al.   Reumatologia Clinica

Systemic calprotectin and chronic inflammatory rheumatic diseases

(2019) Xavier Romand et al.   JOINT BONE SPINE

Pre-analytical and analytical confounders of serum calprotectin as a biomarker in rheumatoid arthritis

(2019) Lieve Van Hoovels et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study

(2018) Barbora Šumová et al.   RHEUMATOLOGY INTERNATIONAL

S100-alarmins: potential therapeutic targets for arthritis

(2017) Judith Austermann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis

(2017) Sang-Cheol Bae et al.   POSTGRADUATE MEDICINE

Calprotectin (S100A8/A9) should preferably be measured in EDTA-plasma; results from a longitudinal study of patients with rheumatoid arthritis

(2017) Hilde Haugedal Nordal et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Calprotectin in patients with chronic rheumatoid arthritis correlates with disease activity and responsiveness to methotrexate

(2017) Ulla Bregendahl Nielsen et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Calprotectin in rheumatic diseases

(2016) Francesca Ometto et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus

(2016) H Tydén et al.   LUPUS

S100A8/A9: From basic science to clinical application

(2016) Monika Pruenster et al.   PHARMACOLOGY & THERAPEUTICS

MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis

(2013) Ivy Y Choi et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased serum levels of S100A8/A9 and S100A12 are associated with cardiovascular disease in patients with inactive systemic lupus erythematosus

(2013) H. Tyden et al.   RHEUMATOLOGY

Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: Studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in

(2011) Anders A. Bengtsson et al.   ARTHRITIS AND RHEUMATISM