Review
Biochemistry & Molecular Biology
Pedro F. N. Souza, Felipe P. Mesquita, Jackson L. Amaral, Patricia G. C. Landim, Karollyny R. P. Lima, Marilia B. Costa, Izabelle R. Farias, Luina B. Lima, Raquel C. Montenegro
Summary: This review discusses the sequence and structural differences of S proteins among SARS-CoV, MERS-CoV, and SARS-CoV-2, highlighting their importance in infection, transmission, and evolution. It also explores the mutations in the receptor-binding domain (RBD) of these coronaviruses, as well as the mutations in the S protein of new isolates of SARS-CoV-2.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Urology & Nephrology
Zilin Wang, Daming Wang, Yuqian Dai, Sha Zhu, Hao Zeng
Summary: Recent studies have shown that SARS-CoV, MERS-CoV, and SARS-CoV-2 coronaviruses have similar effects on the genitourinary system, leading to impairment of kidney and testicular function. Therefore, urologists and nephrologists should pay attention to monitoring the damage caused by coronavirus infections to the genitourinary system.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, Research & Experimental
Fang Wang, Xiao-Guo Suo, Cong Wang, Jia-Nan Wang, Xiao-Yan He, Fa-Cai Wang, Juan Jin, Jia-Gen Wen, Wei-Jian Ni, Bing -Xiang Shen, Xiao-Ming Meng
Summary: The outbreak of SARS-CoV-2 since the end of 2019 has posed a significant public health challenge globally. This virus not only causes pneumonia but also leads to multiple organ failure, including kidney damage, which results in increased mortality and morbidity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Microbiology
Hanan Al-Khalaifah, Mohammad Alotaibi, Afaf Al-Nasser
Summary: This article examines the origin of coronaviruses and the risk of transmission between humans and animals, with a focus on avian coronaviruses and their possible relation to SARS-CoV-2.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soan Park, Jeong Wook Lee
Summary: The study introduces a new nucleic acid detection method that allows fast, sensitive, specific, and colorimetric detection of coronavirus. This method combines reverse transcription loop-mediated amplification with a toehold reaction, enhancing the sensitivity and speed of RNA virus detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Clayton J. Otter, Alejandra Fausto, Li Hui Tan, Alisha S. Khosla, Noam A. Cohen, Susan R. Weiss
Summary: This study compares the replication and cytotoxicity of several coronaviruses in human nasal epithelial cells. The results show that different viruses have different replication abilities and cytotoxic effects, and the status of nasal epithelial cells (such as asthma inflammation) also affects the availability of viral receptors and replication.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Jesus Hurtado-Tamayo, Ricardo Requena-Platek, Luis Enjuanes, Melissa Bello-Perez, Isabel Sola
Summary: Coronaviruses have a large genome and include essential genes as well as variable accessory genes. The functions of accessory proteins in virus-host interactions and pathogenesis are important. Analysis of accessory proteins in the scientific literature generally involves deleting or mutating the genes, but the complexities of protein interactions during virus infection are often overlooked. A critical review of the literature helps to explain discrepancies in experimental results obtained through different approaches.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Dae-Gyun Ahn, Gun Young Yoon, Sunhee Lee, Keun Bon Ku, Chonsaeng Kim, Kyun-Do Kim, Young-Chan Kwon, Geon-Woo Kim, Bum-Tae Kim, Seong-Jun Kim
Summary: Recent outbreaks of zoonotic coronaviruses, such as MERS-CoV and SARS-CoV-2, have caused significant casualties and economic shock. A novel compound, KCB261770, has been identified to effectively inhibit MERS-CoV frameshifting, showing potential as a drug candidate for interfering with pan-coronavirus frameshifting.
Review
Chemistry, Multidisciplinary
Ahmed Al-Hindawi, Usama AlDallal, Yousef Mostafa Waly, Muhammed Hesham Hussain, Mohamed Shelig, Omar Samir Mohamed Megahed Saleh ElMitwalli, G. Roshan Deen, Fryad Z. Henari
Summary: The COVID-19 pandemic has caused significant global impact, and rapid and accurate diagnosis using nanoparticle-based methods has become a focus of research.
Review
Virology
Ariful Islam, Jinnat Ferdous, Shariful Islam, Md Abu Sayeed, Shusmita Dutta Choudhury, Otun Saha, Mohammad Mahmudul Hassan, Tahmina Shirin
Summary: Coronaviruses can infect a variety of animals and humans, causing different diseases and significant impacts on public health and the global economy. Therefore, understanding and preventing the transmission of novel coronaviruses in different animals and humans is crucial.
Review
Cell Biology
Ankit Shroff, Taras Y. Nazarko
Summary: This article discusses the interaction between human coronaviruses and autophagy, including recent SARS-CoV-2-related studies, focusing on understanding the molecular mechanisms for the development of effective therapies against coronaviral diseases.
Review
Chemistry, Medicinal
Thanigaimalai Pillaiyar, Lukas L. Wendt, Manoj Manickam, Maheswaran Easwaran
Summary: Coronaviruses can infect both humans and animals, causing a range of infections. Three beta-coronaviruses, including SARS-CoV-1, MERS-CoV, and SARS-CoV-2, have crossed the species barrier to infect humans. The urgent need for antiviral therapies against these dangerous viruses remains, as no approved vaccines or drugs are currently available.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Virology
Hafiz Abdul Rehman, Farheen Ramzan, Zarrin Basharat, Muhammad Shakeel, Muhammad Usman Ghani Khan, Ishtiaq Ahmad Khan
Summary: The study found that the genome sequences of the novel coronavirus (SARS-CoV-2) are more similar to bat coronaviruses (BAT-CoV), while Middle East respiratory syndrome coronavirus (MERS-CoV) is more distinct from SARS-CoV-2 than BAT-CoV and SARS-CoV.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Environmental Sciences
Priscilla Gomes da Silva, Joao Rodrigo Mesquita, Maria de Sao Jose Nascimento, Vanessa Andreia Martins Ferreira
Summary: Environmental disturbances caused by human activities disrupt wildlife ecosystems and facilitate the zoonotic transmission of pathogens. The high mutation rate and genetic recombination capacity of coronaviruses contribute to outbreaks like SARS, MERS, and COVID-19.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biology
Rui P. Silva, Yimin Huang, Annalee W. Nguyen, Ching-Lin Hsieh, Oladimeji S. Olaluwoye, Tamer S. Kaoud, Rebecca E. Wilen, Ahlam N. Qerqez, Jun-Gyu Park, Ahmed M. Khalil, Laura R. Azouz, Kevin C. Le, Amanda L. Bohanon, Andrea M. DiVenere, Yutong Liu, Alison G. Lee, Dzifa A. Amengor, Sophie R. Shoemaker, Shawn M. Costello, Eduardo A. Padlan, Susan Marqusee, Luis Martinez-Sobrido, Kevin N. Dalby, Sheena D'Arcy, Jason S. McLellan, Jennifer A. Maynard, Leslie Goo
Summary: Understanding the protective potential of conserved epitopes in SARS-CoV-2 and other coronaviruses is crucial for addressing the current pandemic and future outbreaks. Researchers have identified a highly conserved epitope in the S2 domain of beta-coronaviruses, specifically in the hinge region. An antibody called RAY53 targets this epitope and has been found to mediate immune responses against SARS-CoV-2 spike protein. However, mutations in the hinge region and other spike protein changes may impact antibody binding and evade existing serum antibodies. This study provides valuable insights into the targeting of S2 core epitopes and the limitations of this approach.
Article
Surgery
Dushyant Singh Dahiya, Abhilash Perisetti, Neil Sharma, Sumant Inamdar, Hemant Goyal, Amandeep Singh, Laura Rotundo, Rajat Garg, Chin- Cheng, Sailaja Pisipati, Mohammad Al-Haddad, Madhusudhan Sanaka
Summary: This study analyzed the trends of inpatient therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in the United States, focusing on utilization and outcomes related to specific patient demographics. The findings showed increasing utilization and inpatient mortality for a subset of the American minority population, including Black and Hispanics.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Gastroenterology & Hepatology
Abhilash Perisetti, Prateek Sharma
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Abhilash Perisetti, Madhav Desai, Michael J. Bourke, Ian Penman, Alessandro Repici, Duvvur Nageshwar Reddy, Hisao Tajiri, Douglas K. Rex, Cesare Hassan, Prateek Sharma
Summary: The carbon emissions generated by GI endoscopic activity are significant and it is important to recognize them. Despite various limitations, it is urgent to collect proper data and explore new methods for reducing these emissions to achieve sustainable endoscopic practices in the future.
Review
Gastroenterology & Hepatology
Saurabh Chandan, Smit Deliwala, Shahab R. Khan, Babu P. Mohan, Banreet S. Dhindsa, Jay Bapaye, Hemant Goyal, Lena L. Kassab, Faisal Kamal, Harlan R. Sayles, Gursimran S. Kochhar, Douglas G. Adler
Summary: EUS-guided liver biopsy (EUS-LB) has gained popularity with the availability of newer needle designs. A systematic review and meta-analysis comparing EUS-LB and percutaneous LB (PC-LB) demonstrated that PC-LB had higher diagnostic accuracy overall and better performance in terms of complete portal tracts and total specimen length. Further studies are needed to confirm these findings.
ENDOSCOPIC ULTRASOUND
(2023)
Review
Medicine, General & Internal
Jin-Tong Shi, Nuo Chen, Jia Xu, Hemant Goyal, Zhi-Qi Wu, Jie-Xin Zhang, Hua-Guo Xu
Summary: Fecal calprotectin (FC) levels are correlated with the disease activity of inflammatory bowel diseases (IBD), but its usefulness in predicting IBD relapse is yet to be determined. This study aimed to evaluate the efficacy of FC in predicting IBD relapse. A total of 24 prospective studies were included in the meta-analysis, and the optimal FC cut-off value was found to be 152 μg/g. The pooled sensitivity and specificity of FC were 0.720 (0.528 to 0.856) and 0.740 (0.618 to 0.834), respectively. FC is a valuable non-invasive and cost-effective biomarker for early prediction of IBD relapse, with an ideal threshold of 152 μg/g.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Abhilash Perisetti, Benjamin Tharian, Tony C. Tham, Hemant Goyal
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hunain Aslam, Fouzia Oza, Khalid Ahmed, Jonathan Kopel, Mark M. M. Aloysius, Aman Ali, Dushyant Singh Dahiya, Muhammad Aziz, Abhilash Perisetti, Hemant Goyal
Summary: Liver disease is a major public health concern, and researchers are searching for a low-cost, easily accessible, non-invasive marker to monitor and predict liver disorders. The red blood cell distribution width (RDW) has been found to be associated with various inflammatory conditions, suggesting its potential use as a marker for disease progression and prognosis. Multiple factors affect red blood cell production, and dysfunctions in these processes can lead to an increase in RDW. Chronic inflammation also contributes to increased oxidative stress, dysregulation, and reduced erythropoiesis, further increasing RDW. This literature review explores the pathophysiology behind the increase in RDW and its potential correlation with various chronic liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Immunology
Wandong Hong, Jingye Pan, Hemant Goyal, Maddalena Zippi
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Jonathan Kopel, Hemant Goyal
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Mark M. Aloysius, Tejas Nikumbh, Hemant Goyal, Nirav Thosani
GASTROINTESTINAL ENDOSCOPY
(2023)
Editorial Material
Medicine, General & Internal
Rupinder Mann, Hemant Goyal, Abhilash Perisetti
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Harishankar Gopakumar, Vinay Jahagirdar, Jagadish Koyi, Dushyant Singh Dahiya, Hemant Goyal, Neil R. Sharma, Abhilash Perisetti
Summary: Neuroendocrine tumors (NET) primarily arise from cells throughout the diffuse endocrine system and are most commonly seen in the gastrointestinal tract, pancreas, and lungs. The incidence of NETs is increasing due to improved diagnostic modalities and their increasing use. Endoscopic evaluation plays a crucial role in diagnosing, staging, and grading NETs, and advanced endoscopic techniques can successfully treat smaller NETs, potentially reducing the need for surgery.