Calprotectin in rheumatic diseases

Pro-inflammatory S100A9 Protein as a Robust Biomarker Differentiating Early Stages of Cognitive Impairment in Alzheimer’s Disease

(2015) Istvan Horvath et al.   ACS Chemical Neuroscience

Prolonged remission in Caucasian patients with SLE: prevalence and outcomes

(2015) Margherita Zen et al.   ANNALS OF THE RHEUMATIC DISEASES

Fecal calprotectin in systemic sclerosis and review of the literature

(2015) I. Marie et al.   AUTOIMMUNITY REVIEWS

Serum calprotectin—a promising diagnostic marker for adult-onset Still’s disease

(2015) Qian Guo et al.   CLINICAL RHEUMATOLOGY

Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation

(2015) Chih-Ru Lin et al.   FASEB JOURNAL

Elevated Serum Levels of Calprotectin (Myeloid-Related Protein 8/14) in Patients With Ankylosing Spondylitis and Its Association With Disease Activity and Quality of Life

(2015) Pelin Oktayoglu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis

(2014) Maureen C Turina et al.   ANNALS OF THE RHEUMATIC DISEASES

Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype

(2014) L van Bon et al.   ANNALS OF THE RHEUMATIC DISEASES

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

(2014) Selina K. Fassl et al.   JOURNAL OF IMMUNOLOGY

Abnormally Differentiating Keratinocytes in the Epidermis of Systemic Sclerosis Patients Show Enhanced Secretion of CCN2 and S100A9

(2014) Joanna Nikitorowicz-Buniak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Pro-Apoptotic and Pro-Inflammatory Effects of Calprotectin on Human Periodontal Ligament Cells

(2014) Yunfei Zheng et al.   PLoS One

Autophagy, Inflammation and Innate Immunity in Inflammatory Myopathies

(2014) Cristina Cappelletti et al.   PLoS One

Identification of S100A9 as Biomarker of Responsiveness to the Methotrexate/Etanercept Combination in Rheumatoid Arthritis Using a Proteomic Approach

(2014) Antoine Obry et al.   PLoS One

Elevated serum levels of calprotectin (MRP8/MRP14) in patients with Behçet's disease and its association with disease activity and quality of life

(2014) Pelin Oktayoglu et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis

(2014) EAM Mahler et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Calprotectin (S100A8/9) as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis

(2014) Maureen C Turina et al.   ARTHRITIS RESEARCH & THERAPY

Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity

(2014) Thomas Vogl et al.   Nature Communications

MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis

(2013) Ivy Y Choi et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased expression of S100A8 and S100A9 in patients with diffuse cutaneous systemic sclerosis. A correlation with organ involvement and immunological abnormalities

(2013) Xue Xu et al.   CLINICAL RHEUMATOLOGY

VIP Modulates IL-22R1 Expression and Prevents the Contribution of Rheumatoid Synovial Fibroblasts to IL-22-Mediated Joint Destruction

(2013) Mar Carrión et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis

(2013) Ruth J. Pepper et al.   KIDNEY INTERNATIONAL

Calprotectin in Rheumatoid Arthritis

(2013) Miriam García-Arias et al.   Molecular Diagnosis & Therapy

Biomarkers from bronchoalveolar lavage fluid in systemic sclerosis patients with interstitial lung disease relate to severity of lung fibrosis

(2013) Roger Hesselstrand et al.   RESPIRATORY MEDICINE

IL-22/IL-22R1 axis and S100A8/A9 alarmins in human osteoarthritic and rheumatoid arthritis synovial fibroblasts

(2013) Mar Carrión et al.   RHEUMATOLOGY

Calprotectin (S100A8/A9), S100A12, and EDTA-resistant S100A12 complexes (ERAC) in primary Sjögren’s syndrome

(2013) HH Nordal et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis

(2013) Kiran Nistala et al.   ARTHRITIS RESEARCH & THERAPY

The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis

(2012) Dirk Holzinger et al.   ANNALS OF THE RHEUMATIC DISEASES

Toll-Like Receptors Promote Inflammation in Idiopathic Inflammatory Myopathies

(2012) Anna Brunn et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The transition of acute to chronic bowel inflammation in spondyloarthritis

(2012) Liesbet Van Praet et al.   Nature Reviews Rheumatology

Lipopolysaccharide Induces Lung Fibroblast Proliferation through Toll-Like Receptor 4 Signaling and the Phosphoinositide3-Kinase-Akt Pathway

(2012) Zhengyu He et al.   PLoS One

An Inflammation Loop Orchestrated by S100A9 and Calprotectin Is Critical for Development of Arthritis

(2012) Annabelle Cesaro et al.   PLoS One

Calprotectin in ankylosing spondylitis – frequently elevated in feces, but normal in serum

(2012) Eva Klingberg et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: Implications for bone destruction in murine antigen-induced arthritis

(2011) Lilyanne C. Grevers et al.   ARTHRITIS AND RHEUMATISM

Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and c

(2011) Susanne Juhl Pedersen et al.   ARTHRITIS AND RHEUMATISM

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

S100A9 Differentially Modifies Phenotypic States of Neutrophils, Macrophages, and Dendritic Cells

(2011) Michelle M. Averill et al.   CIRCULATION

The subclinic autonomic dysfunction in patients with Behçet disease: an electrophysiological study

(2011) Pınar Borman et al.   CLINICAL RHEUMATOLOGY

Damage-Associated Molecular Pattern S100A9 Increases Bactericidal Activity of Human Neutrophils by Enhancing Phagocytosis

(2011) J.-C. Simard et al.   JOURNAL OF IMMUNOLOGY

Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages

(2011) Seiko Aochi et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

S100A8/A9 Activate Key Genes and Pathways in Colon Tumor Progression

(2011) M. Ichikawa et al.   MOLECULAR CANCER RESEARCH

Gene expression profiling in peripheral blood cells of patients with rheumatoid arthritis in response to anti-TNF-α treatments

(2011) E. Meugnier et al.   PHYSIOLOGICAL GENOMICS

Value of ANCA measurements during remission to predict a relapse of ANCA-associated vasculitis--a meta-analysis

(2011) G. Tomasson et al.   RHEUMATOLOGY

Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis

(2011) Lucie Andrés Cerezo et al.   ARTHRITIS RESEARCH & THERAPY

Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus

(2011) Christian Lood et al.   ARTHRITIS RESEARCH & THERAPY

The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab

(2011) Hilde Hammer et al.   ARTHRITIS RESEARCH & THERAPY

Cellular characterization of the gouty tophus: A quantitative analysis

(2010) Nicola Dalbeth et al.   ARTHRITIS AND RHEUMATISM

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Faecal calprotectin: a biomarker of gastrointestinal disease in systemic sclerosis

(2010) K. Andréasson et al.   JOURNAL OF INTERNAL MEDICINE

Serum Calprotectin as a Marker for Disease Activity and Severity in Adult-onset Still's Disease

(2010) S. Y. JUNG et al.   JOURNAL OF RHEUMATOLOGY

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

(2010) Shaun A. Summers et al.   KIDNEY INTERNATIONAL

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases

(2010) A. Baillet et al.   RHEUMATOLOGY

Rheumatoid arthritis progression mediated by activated synovial fibroblasts

(2010) Elena Neumann et al.   TRENDS IN MOLECULAR MEDICINE

Methods used to assess remission and low disease activity in rheumatoid arthritis

(2009) Francesca Ometto et al.   AUTOIMMUNITY REVIEWS

Myeloid-Related Protein-8/14 Is Critical for the Biological Response to Vascular Injury

(2009) Kevin Croce et al.   CIRCULATION

Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis

(2009) Geun-Tae Kim et al.   CLINICAL RHEUMATOLOGY

Monitoring disease activity by stool analyses: from occult blood to molecular markers of intestinal inflammation and damage

(2009) D Foell et al.   GUT

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

(2009) Helen J. Lachmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phagocyte-specific S100A8/A9 Protein Levels During Disease Exacerbations and Infections in Systemic Lupus Erythematosus

(2009) M. S. SOYFOO et al.   JOURNAL OF RHEUMATOLOGY

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Calprotectin (a major S100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis

(2008) H B. Hammer et al.   ANNALS OF THE RHEUMATIC DISEASES

Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis

(2008) P. L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Binding of S100 proteins to RAGE: An update

(2008) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Monomeric Calgranulins Measured by SELDI-TOF Mass Spectrometry and Calprotectin Measured by ELISA as Biomarkers in Arthritis

(2008) D. de Seny et al.   CLINICAL CHEMISTRY

Calgranulin B (S100A9) Levels in Bronchoalveolar Lavage Fluid of Patients with Interstitial Lung Diseases

(2008) E. Bargagli et al.   INFLAMMATION

Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity

(2008) Ayumi Yoshizaki et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Calprotectin (a major leucocyte protein) is associated with the levels of anti‐CCP and rheumatoid factor in a longitudinal study of patients with very early rheumatoid arthritis

(2008) H. B. Hammer et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis

(2007) P L E M van Lent et al.   ANNALS OF THE RHEUMATIC DISEASES

S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes

(2007) Takamasa Nukui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY